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Baclofen

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Identification
Molecular formula
C10H12ClNO2
CAS number
1134-47-0
IUPAC name
(4-chlorophenyl)methyl-(3-hydroxy-3-phenyl-propyl)ammonium;chloride
State
State

At room temperature, baclofen is a stable solid and commonly available in tablet form.

Melting point (Celsius)
204.00
Melting point (Kelvin)
477.15
Boiling point (Celsius)
302.00
Boiling point (Kelvin)
575.15
General information
Molecular weight
213.66g/mol
Molar mass
213.6620g/mol
Density
1.2607g/cm3
Appearence

Baclofen is typically found as a white or off-white crystalline powder. It is slightly soluble in water, more soluble in alcohols, and very soluble in chloroform. The powder is often used in tablet form for medical applications.

Comment on solubility

Solubility of (4-chlorophenyl)methyl-(3-hydroxy-3-phenyl-propyl)ammonium;chloride

The solubility characteristics of (4-chlorophenyl)methyl-(3-hydroxy-3-phenyl-propyl)ammonium;chloride can be quite intriguing. This compound, due to its ammonium chloride structure, is likely to exhibit notable solubility in water. Here are some points to consider:

  • Polar Nature: The presence of the quaternary ammonium group contributes to its polar characteristics, enhancing its solubility in polar solvents such as water.
  • Hydrogen Bonding: The hydroxyl group in the structure can engage in hydrogen bonding with water molecules, further facilitating solubility.
  • Chloride Ion Dissociation: As a salt, the dissociation of chloride ions in solution likely aids in the overall solubility performance of the compound.

In summary, due to its polar nature and the ability to form hydrogen bonds, (4-chlorophenyl)methyl-(3-hydroxy-3-phenyl-propyl)ammonium;chloride is expected to be soluble in water, making it a potentially useful compound in various aqueous applications.

Interesting facts

Interesting Facts about (4-chlorophenyl)methyl-(3-hydroxy-3-phenyl-propyl)ammonium;chloride

(4-chlorophenyl)methyl-(3-hydroxy-3-phenyl-propyl)ammonium;chloride is a compound that belongs to a fascinating class of quaternary ammonium salts, which are known for their wide range of applications in various fields. Here are some captivating points about this compound:

  • Quaternary Ammonium Salts: These compounds are characterized by a nitrogen atom that is bonded to four organic groups. They often exhibit remarkable antimicrobial properties, making them vital in disinfectants and sanitizers.
  • Versatile Applications: Due to its unique structure, this compound may be utilized in pharmaceuticals, particularly in drug formulations that require a specific hydrophilic-lipophilic balance to achieve the desired therapeutic effects.
  • Structure-Activity Relationship (SAR): The incorporation of a 4-chlorophenyl group along with a phenyl-substituted hydroxypropyl moiety can influence the compound's biological activities, leading to exciting research opportunities in medicinal chemistry.
  • Mechanism of Action: Quaternary ammonium compounds can disrupt microbial cell membranes, showcasing their importance in the ongoing battle against antibiotic-resistant bacteria.
  • Environmental Considerations: While their antimicrobial properties make them beneficial, it's essential to understand the environmental impact of these compounds, particularly their potential persistence and toxicity in aquatic ecosystems.

In summary, (4-chlorophenyl)methyl-(3-hydroxy-3-phenyl-propyl)ammonium;chloride is not just a chemical entity but a gateway to understanding various biological processes and environmental interactions. Its presence in scientific research highlights the endless possibilities that chemistry offers in addressing real-world challenges.

Synonyms
BS-32
alpha-(1-((p-Chlorobenzyl)amino)ethyl)benzyl alcohol hydrochloride
BENZYL ALCOHOL, alpha-(1-((p-CHLOROBENZYL)AMINO)ETHYL)-, HYDROCHLORIDE
18864-08-9