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4-Chloropyridine

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Identification
Molecular formula
C5H4ClN
CAS number
1122-78-9
IUPAC name
4-chloropyridine
State
State

At room temperature, 4-Chloropyridine is a liquid. This is typical for many small heteroaromatic compounds, especially those that are chlorinated, which tend to have lower melting points than their unsubstituted counterparts.

Melting point (Celsius)
-7.00
Melting point (Kelvin)
266.15
Boiling point (Celsius)
184.00
Boiling point (Kelvin)
457.15
General information
Molecular weight
113.55g/mol
Molar mass
113.5500g/mol
Density
1.2090g/cm3
Appearence

4-Chloropyridine is a colorless liquid that may appear slightly yellow due to impurities. It emits a weak and acrid odor that is characteristic of many chlorinated pyridine compounds. This compound is often used in research and industrial applications, where its appearance and moderate stability are of importance. Due to its liquid state at room temperature, it is often handled with caution to avoid inhalation or skin contact.

Comment on solubility

Solubility of 4-chloropyridine

4-chloropyridine, with the chemical formula C5H4ClN, exhibits interesting solubility characteristics that are important for various applications in organic chemistry and pharmaceuticals. Here are some notable points regarding its solubility:

  • Solvent Compatibility: 4-chloropyridine is soluble in polar organic solvents such as ethanol and acetone, which enhances its utility in synthesis processes.
  • Water Solubility: Although it is poorly soluble in water, the polar nature of 4-chloropyridine allows it to interact with aqueous solutions to some extent, making it a compound of interest in applications where water solubility is a factor.
  • pH Dependence: The solubility may be affected by the pH of the solution, potentially increasing in acidic conditions, due to ionization of the nitrogen atom in the pyridine ring.

Overall, understanding the solubility of 4-chloropyridine is crucial for maximizing its potential in various chemical reactions and formulations. As highlighted, its compatibility with polar solvents and partial water solubility can significantly influence its behavior in diverse chemical environments.

Interesting facts

Interesting Facts about 4-Chloropyridine

4-Chloropyridine is an intriguing compound with a variety of applications in both organic synthesis and medicinal chemistry. Here are some fascinating aspects about this chlorine-substituted pyridine:

  • Structural Significance: As a member of the pyridine family, 4-chloropyridine features a heterocyclic aromatic ring. The presence of the chlorine atom at the 4-position contributes to its unique chemical reactivity and properties.
  • Industrial Applications: This compound is widely used in the manufacture of agrochemicals, especially herbicides and pesticides. It plays a crucial role in developing compounds that enhance agricultural productivity.
  • Synthesis of Pharmaceuticals: 4-Chloropyridine serves as an important intermediate in synthesizing various pharmaceuticals. Its versatility allows for the production of biologically active molecules used in treating a range of diseases.
  • Research Applications: In the laboratory, 4-chloropyridine is often used as a building block for synthesizing other chemical entities. Its reactivity with various nucleophiles makes it valuable for creating diverse products.
  • Environmental Impact: While useful, the chlorine atom in 4-chloropyridine raises concerns regarding its potential environmental persistence and toxicity. Proper safety measures are essential when handling this compound to mitigate any ecological risks.

The study of 4-chloropyridine exemplifies how modifications in molecular structure can lead to a myriad of properties and applications, showcasing the intricate balance of chemistry and industry.


Synonyms
4-CHLOROPYRIDINE
626-61-9
DTXSID0052671
DTXCID608484
210-956-2
Pyridine, 4-chloro-
4-chloro-pyridine
CHEMBL5290039
EINECS 210-956-2
BRN 0105875
p-Chloropyridine
4-chloro pyridine
4- Chloropyridine
4-chloranylpyridine
MFCD00044570
SCHEMBL6842
5-20-05-00410 (Beilstein Handbook Reference)
HSDB 8486
PVMNPAUTCMBOMO-UHFFFAOYSA-
BDBM50622791
STL565226
AKOS015995550
BS-22389
CS-0139547
NS00035122
EN300-33957
F17303
A833912
Q229945
F8880-0669
InChI=1/C5H4ClN/c6-5-1-3-7-4-2-5/h1-4H