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(4-Cyclohexylpiperazin-1-yl)-(3,4,5-trimethoxyphenyl)methanone

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Identification
Molecular formula
C20H30N2O4
CAS number
400902-47-0
IUPAC name
(4-cyclohexylpiperazin-1-yl)-(3,4,5-trimethoxyphenyl)methanone
State
State

At room temperature, it is usually found in a solid state, most often utilized in laboratories for research purposes. The compound should be stored in dry, cool conditions to maintain its stability and prevent degradation.

Melting point (Celsius)
178.00
Melting point (Kelvin)
451.15
Boiling point (Celsius)
400.00
Boiling point (Kelvin)
673.15
General information
Molecular weight
346.47g/mol
Molar mass
346.4500g/mol
Density
1.2030g/cm3
Appearence

The compound is typically a crystalline solid with a white to off-white appearance. It may appear in powder form for use in chemical synthesis and research applications.

Comment on solubility

Solubility of (4-cyclohexylpiperazin-1-yl)-(3,4,5-trimethoxyphenyl)methanone

The solubility of the compound (4-cyclohexylpiperazin-1-yl)-(3,4,5-trimethoxyphenyl)methanone can significantly influence its applications in various fields, particularly in pharmaceuticals and materials science.

In general, the solubility of such organic compounds can be influenced by several key factors:

  • Polarity: The presence of the piperazine moiety may enhance hydrophilic character, suggesting potential solubility in polar solvents.
  • Hydrogen Bonding: Functional groups capable of forming hydrogen bonds can increase solubility in water. The trimethoxyphenyl group, which contains ether functionalities, may also contribute to solubility characteristics.
  • Temperature: Like many organic compounds, solubility often increases with temperature, which means that solubility testing should consider temperature variations.
  • pH Levels: Since the solute’s solubility might change according to the pH of the solution, testing across different pH levels can provide insights into its solubility behavior.

While specific solubility data for this compound may not be readily available, it is reasonable to hypothesize that it will exhibit moderate solubility in a range of solvents, given the structural features. Understanding these solubility characteristics is crucial for effective formulation and application.

As a guiding principle in solubility analysis, remember: "Like dissolves like." Therefore, exploring various solvents—both polar and non-polar—will yield valuable information about this compound’s solubility profile.

Interesting facts

Interesting Facts about (4-Cyclohexylpiperazin-1-yl)-(3,4,5-trimethoxyphenyl)methanone

This compound, known for its intriguing molecular structure, belongs to the class of piperazine derivatives, which are often explored in medicinal chemistry due to their diverse biological activities. Here are some fascinating insights:

  • Pharmacological Potential: Compounds related to piperazine exhibit a wide range of pharmacological effects, making them valuable in the development of new medications. They are often investigated for their roles as antidepressants, antipsychotics, and anxiolytics.

  • Structural Features: The presence of the cyclohexyl group lends unique steric properties, which can influence the biological activity and selectivity of the compound. Additionally, the trimethoxyphenyl moiety can enhance solubility and interaction with biological targets.

  • Research Applications: Due to its complex structure, (4-cyclohexylpiperazin-1-yl)-(3,4,5-trimethoxyphenyl)methanone serves as a promising scaffold in structure-activity relationship (SAR) studies, helping scientists understand how modifications affect potency and efficacy.

  • Analogous Compounds: This compound can be compared to other piperazine-based derivatives that have shown potential in treating neurological disorders, showcasing the versatility of the piperazine framework in drug design.

  • Mechanism of Action: While the exact mechanism of action for this specific compound is yet to be fully elucidated, many piperazine derivatives operate by modulating neurotransmitter systems, particularly serotonin and dopamine, essential for mood regulation.

In summary, (4-cyclohexylpiperazin-1-yl)-(3,4,5-trimethoxyphenyl)methanone represents an exciting compound in medicinal chemistry. Its unique structure opens avenues for further investigation and development, enhancing our understanding of how molecular modifications can impact biological activity.

Synonyms
17837-64-8
1-Cyclohexyl-4-(3,4,5-trimethoxybenzoyl)piperazine
BRN 1594034
4-Cyclohexylpiperazinyl 3,4,5-trimethoxyphenyl ketone
KETONE, 4-CYCLOHEXYLPIPERAZINYL 3,4,5-TRIMETHOXYPHENYL
Piperazine, 1-cyclohexyl-4-(3,4,5-trimethoxybenzoyl)-
DTXSID50170464
5-23-01-00154 (Beilstein Handbook Reference)
DTXCID5092955
4-Cyclohexyl-1-piperazinyl(3,4,5-trimethoxyphenyl) ketone
(4-cyclohexylpiperazin-1-yl)-(3,4,5-trimethoxyphenyl)methanone
Cambridge id 6033173
Oprea1_220340
CHEMBL1616309
STK146754
AKOS005405969
NCGC00245381-01
NCGC00245381-02
ST45111937
AP-263/43316665
(4-cyclohexylpiperazin-1-yl)(3,4,5-trimethoxyphenyl)methanone
(4-CYCLOHEXYLPIPERAZINO)(3,4,5-TRIMETHOXYPHENYL)METHANONE