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Naproxen

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Identification
Molecular formula
C14H14NO2
CAS number
22204-53-1
IUPAC name
4-(diethylamino)-2-(1-naphthyl)butanoic acid
State
State

At room temperature, naproxen is typically in a solid state.

Melting point (Celsius)
152.00
Melting point (Kelvin)
425.15
Boiling point (Celsius)
215.00
Boiling point (Kelvin)
488.15
General information
Molecular weight
230.27g/mol
Molar mass
230.3060g/mol
Density
1.1200g/cm3
Appearence

Naproxen is a white to off-white crystalline solid.

Comment on solubility

Solubility of 4-(diethylamino)-2-(1-naphthyl)butanoic acid

The solubility of 4-(diethylamino)-2-(1-naphthyl)butanoic acid in various solvents is an intriguing aspect of its chemical behavior. This compound, known for its unique structure, exhibits differing solubility characteristics based on solvent polarity and temperature.

Factors Affecting Solubility

Several factors contribute to the solubility of this acid:

  • Polarity of Solvent: Generally, polar solvents dissolve polar substances, while nonpolar solvents favor nonpolar ones. This compound's moderate polarity tends to favor solubility in polar organic solvents.
  • Temperature: Increased temperature often enhances solubility by providing kinetic energy that helps break intermolecular forces.
  • Hydrogen Bonding: The presence of hydrogen bonding capabilities can significantly impact solubility, allowing for interactions with the solvent molecules.

Solubility Insights

In practice,

  • 4-(diethylamino)-2-(1-naphthyl)butanoic acid is expected to be soluble in organic solvents like ethanol and dimethyl sulfoxide (DMSO).
  • However, its solubility in water is likely to be low due to the nonpolar naphthyl group which hinders interaction with water molecules.

In conclusion, to understand the solubility of 4-(diethylamino)-2-(1-naphthyl)butanoic acid, one must consider the specific solvent environment and the compound's structural attributes. This interplay of factors provides a fascinating glimpse into the compound's behavior in various chemical contexts.

Interesting facts

Interesting Facts about 4-(Diethylamino)-2-(1-naphthyl)butanoic Acid

4-(Diethylamino)-2-(1-naphthyl)butanoic acid, commonly referred to as a member of the class of compounds known as β-amino acids, is notable for its diverse applications in both pharmaceuticals and materials science. Here are some intriguing aspects of this compound:

  • Pharmaceutical Relevance: This compound is often studied for its role as a potential therapeutic agent, particularly in the field of pain management and neurology. Its ability to affect neurotransmitter pathways makes it a subject of interest for developing pain relief medications.
  • Structure-Activity Relationship: The unique structure, featuring a diethylamino group and a naphthyl moiety, provides insight into how altering molecular frameworks can influence biological activity. This relationship is crucial in medicinal chemistry for the design of more effective drugs.
  • Racemic Mixture: The compound exists in a chiral form, leading to different biological activities for each enantiomer. This raises exciting considerations in the synthesis and testing of specific stereoisomers for enhanced therapeutic efficacy.
  • Role in Organic Synthesis: As a building block in organic synthesis, 4-(diethylamino)-2-(1-naphthyl)butanoic acid is used to construct more complex chemical entities, showcasing the versatility of amino acids in synthetic chemistry.
  • Potential in Material Science: The compound's unique properties may also lend themselves to applications in the development of polymers and light-emitting materials, linking organic chemistry with advanced material design.

In summary, 4-(diethylamino)-2-(1-naphthyl)butanoic acid embodies the *interdisciplinary nature of chemistry*, bridging the gap between life sciences and material innovations. As we continue to explore its capabilities, it is certain that new applications and insights will emerge, highlighting the dynamic landscape of chemical research.