Skip to main content

Loperamide

ADVERTISEMENT
Identification
Molecular formula
C29H33ClFN2O2
CAS number
34552-83-5
IUPAC name
4-(diethylamino)-N-(5-ethyl-2-fluoro-phenyl)butanamide
State
State

At room temperature, loperamide exists as a solid.

Melting point (Celsius)
224.00
Melting point (Kelvin)
497.15
Boiling point (Celsius)
527.10
Boiling point (Kelvin)
800.25
General information
Molecular weight
478.03g/mol
Molar mass
478.0690g/mol
Density
1.3572g/cm3
Appearence

Loperamide is typically a white or slightly yellowish powder. It appears crystalline in nature and is generally odorless.

Comment on solubility

Solubility of 4-(diethylamino)-N-(5-ethyl-2-fluoro-phenyl)butanamide

The solubility of 4-(diethylamino)-N-(5-ethyl-2-fluoro-phenyl)butanamide in various solvents is a fascinating subject. This compound, primarily categorized under amides, exhibits distinct solubility behaviors due to its molecular structure and functional groups.

Here are some key factors that influence its solubility:

  • Polarity: The presence of the diethylamino group may enhance solubility in polar solvents like water, while the ethyl and fluoro groups could lead to variable solubility in non-polar solvents.
  • Hydrogen Bonding: As an amide, it can engage in hydrogen bonding with solvents, which typically increases solubility.
  • Steric Effects: The bulky diethylamino group may hinder optimal interactions with the solvent, potentially affecting the overall solubility.
  • Temperature: Solubility may vary significantly with changes in temperature; generally, higher temperatures increase solubility for solid substances.

In summary, while it is likely that 4-(diethylamino)-N-(5-ethyl-2-fluoro-phenyl)butanamide displays notable solubility in polar solvents, the exact degree can vary widely based on the solvent environment and temperature conditions. Understanding these properties can provide valuable insights into its potential applications in various fields.

Interesting facts

Interesting Facts about 4-(Diethylamino)-N-(5-ethyl-2-fluoro-phenyl)butanamide

This compound belongs to the class of chemical substances known as butanamides, featuring notable applications in the realm of pharmaceuticals. Here are some engaging points to illuminate its significance:

  • Pharmaceutical Relevance: Compounds like this one often serve as intermediates or active pharmaceutical ingredients (APIs) in drug formulation, particularly in areas addressing neurological disorders and pain management.
  • Structure-Activity Relationship: The unique diethylamino and 2-fluoro substitutions are crucial for modulating biological activity, often enhancing the compound's interaction with target receptors.
  • Investigative Studies: This compound has been the subject of various research studies aimed at understanding its metabolic pathway and pharmacodynamics, providing insight into how structural modifications can lead to improved efficacy or reduced side effects.
  • Complex Synthesis: The synthesis of such compounds can be intricate, requiring specialized techniques like reductive amination and careful handling of fluorinated reagents, showcasing the challenges chemists often face.
  • Potential for Innovation: As research continues, compounds like this one contribute to the discovery of new medications, illustrating the ever-evolving landscape of medicinal chemistry.

In summary, 4-(diethylamino)-N-(5-ethyl-2-fluoro-phenyl)butanamide is more than just a chemical formula; it represents a bridge between chemistry, pharmacology, and innovative drug development. As scientists push forward, the potential for discovering groundbreaking therapies remains an exciting frontier.

Synonyms
BRN 2698825
BUTYRANILIDE, 4-(DIETHYLAMINO)-5'-ETHYL-2'-FLUORO-
736-12-9
4-(Diethylamino)-5'-ethyl-2'-fluorobutyranilide
gamma-Diaethylamino-3-aethyl-6-fluor-butyranilid [German]
Butanamide, 4-(diethylamino)-N-(5-ethyl-2-fluorophenyl)-
DTXSID30223785
gamma-Diaethylamino-3-aethyl-6-fluor-butyranilid
DTXCID60146276