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Lidocaine

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Identification
Molecular formula
C14H22N2O
CAS number
137-58-6
IUPAC name
4-(diethylamino)-N-(5-ethyl-2-methoxy-phenyl)butanamide
State
State

At room temperature, lidocaine is generally found in a solid, crystalline form.

Melting point (Celsius)
66.00
Melting point (Kelvin)
339.15
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.15
General information
Molecular weight
234.33g/mol
Molar mass
234.3340g/mol
Density
1.0260g/cm3
Appearence

Lidocaine is typically encountered as a white to nearly white crystalline powder. It is odorless and has a slightly bitter taste.

Comment on solubility

Solubility of 4-(diethylamino)-N-(5-ethyl-2-methoxy-phenyl)butanamide

The solubility of 4-(diethylamino)-N-(5-ethyl-2-methoxy-phenyl)butanamide in various solvents is a significant factor to consider for its applications. Generally speaking, the solubility of such amides is influenced by several key factors:

  • Polarity: The presence of polar groups, such as amides and ether linkages, generally enhances solubility in polar solvents like water and alcohols.
  • Alkyl Groups: The diethylamino group introduces hydrophobic characteristics that can affect solubility. Larger alkyl chains may reduce solubility in polar solvents.
  • Temperature: Solubility often increases with temperature, allowing for better dissolution in solvents when heated.
  • pH Levels: The ionization of the amide under varying pH conditions may further alter its solubility profile.

In practical terms, one can expect that:

  • 4-(diethylamino)-N-(5-ethyl-2-methoxy-phenyl)butanamide may show reasonable solubility in organic solvents such as ethanol and dimethyl sulfoxide (DMSO).
  • Its solubility in water may be limited due to the hydrophobic nature of the diethylamino group.

In summary, the solubility behavior of this compound is a complex interplay of structural characteristics and environmental factors, making it essential to conduct specific solubility tests for detailed insights.

Interesting facts

Interesting Facts about 4-(diethylamino)-N-(5-ethyl-2-methoxy-phenyl)butanamide

This fascinating compound, often referred to in scientific circles as an alkylated phenylbutanamide, showcases the intricate interplay between organic synthesis and medicinal applications. Here are some compelling insights about this compound:

  • Potential Pharmacological Activities: Researchers are continuously exploring compounds like this for their potential pharmacological effects, particularly in the realm of pharmaceuticals.
  • Structural Versatility: The presence of the diethylamino group adds to its structural diversity, which can influence its solubility and biological activity. The variations in the ethyl substituents can also affect the compound's interaction with biological targets.
  • Role of the Phenyl Group: The phenyl component, specifically the 5-ethyl-2-methoxy substitution, provides significant steric and electronic influence, enhancing the compound's reactivity and potentially its interaction with receptors in biological systems.
  • Importance in Drug Design: Compounds that exhibit structural complexity, like this one, are often key components in drug design. They can be modified to optimize effectiveness, reducing side effects while increasing therapeutic efficacy.
  • Research Applications: Beyond medicinal chemistry, this compound might be utilized in various research settings, including studies focused on synthetic chemistry, biochemistry, and molecular biology.

It is essential to emphasize the importance of such compounds in the ongoing search for new drugs and the understanding of complex biological systems. The evolution of compounds like 4-(diethylamino)-N-(5-ethyl-2-methoxy-phenyl)butanamide sheds light on the remarkable potential for innovation in chemical sciences.

Synonyms
BRN 2813019
o-BUTYRANISIDIDE, 4-(DIETHYLAMINO)-5'-ETHYL-
4-(Diethylamino)-5'-ethyl-o-butyranisidide
Butanamide, 4-(diethylamino)-N-(5-ethyl-2-methoxyphenyl)-
1157-91-1
gamma-Diaethylamino-3-aethyl-6-methoxy-butyranilid [German]
DTXSID50151172
gamma-Diaethylamino-3-aethyl-6-methoxy-butyranilid
DTXCID0073663