Skip to main content

Lidocaine

ADVERTISEMENT
Identification
Molecular formula
C14H22N2O
CAS number
137-58-6
IUPAC name
4-(diethylamino)-N-(5-ethyl-2-methyl-phenyl)butanamide
State
State

At room temperature, lidocaine is in a solid state. It is available in different forms, including base and hydrochloride salt, which is used in aqueous solutions for medical applications.

Melting point (Celsius)
68.00
Melting point (Kelvin)
341.15
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.15
General information
Molecular weight
234.34g/mol
Molar mass
234.3380g/mol
Density
1.0260g/cm3
Appearence

Lidocaine appears as a white to slightly yellow crystalline powder. It is odorless and has a slightly bitter taste. The compound is often used in its hydrochloride salt form, which is also a white, crystalline substance that is soluble in water.

Comment on solubility

Solubility of 4-(diethylamino)-N-(5-ethyl-2-methyl-phenyl)butanamide

The solubility of 4-(diethylamino)-N-(5-ethyl-2-methyl-phenyl)butanamide in various solvents can be intriguing due to its complex structure. Its solubility characteristics are influenced by several factors, including:

  • Polarity: The presence of a diethylamino group increases its polarity, which can enhance solubility in polar solvents such as water.
  • Hydrophobic Regions: The 5-ethyl-2-methyl-phenyl moiety introduces hydrophobic characteristics, which may promote solubility in organic solvents like ethanol or acetone.
  • Temperature: Solubility can vary with changes in temperature; generally, increased temperature leads to higher solubility.
  • pH Levels: The ionization state of the diethylamino group may be affected by pH, impacting solubility in aqueous solutions.

Therefore, 4-(diethylamino)-N-(5-ethyl-2-methyl-phenyl)butanamide is likely to exhibit:

  1. Good solubility in polar solvents due to its amino group.
  2. Moderate solubility in non-polar organic solvents because of its hydrophobic regions.

Understanding the solubility of this compound is essential for applications in pharmaceutical formulations and organic synthesis, allowing for insights into its behavior and efficacy.

Interesting facts

Interesting Facts about 4-(diethylamino)-N-(5-ethyl-2-methyl-phenyl)butanamide

This compound belongs to a class of chemicals known as amides and carries intriguing biochemical implications. Here are some fascinating aspects of this compound:

  • Pharmacological Potential: Compounds with similar structures are often explored for their ability to interact with biological systems. They may have potential as pharmaceutical agents or drug candidates.
  • Structural Features: The presence of a diethylamino group enhances the lipophilicity of the compound, allowing it to cross biological membranes effectively. This is vital for its potential biological activity.
  • Substituent Influence: The ethyl and methyl substitutions on the aromatic ring can influence the compound's reactivity and stability. Substituents can affect pharmacokinetic properties like absorption, distribution, metabolism, and excretion (ADME).
  • Analytical Interest: Such compounds can be of significant interest in analytical chemistry for techniques involving spectroscopy or chromatography. Understanding their behavior can help in developing new methodologies for detection.
  • Research Significance: Due to its unique structure, this compound may serve as a lead compound in medicinal chemistry, leading to the development of new therapeutic agents.

In summary, 4-(diethylamino)-N-(5-ethyl-2-methyl-phenyl)butanamide embodies a wealth of potential for scientific exploration, indicating its importance in both research and practical applications.

Synonyms
BRN 2697685
4-(Diethylamino)-5'-ethyl-2'-methylbutyranilide
o-BUTYROTOLUIDIDE, 4-(DIETHYLAMINO)-5'-ETHYL-
672-11-7
Butanamide, 4-(diethylamino)-N-(5-ethyl-2-methylphenyl)-
gamma-Diaethylamino-3-aethyl-6-methyl-butyranilid [German]
DTXSID80217477
gamma-Diaethylamino-3-aethyl-6-methyl-butyranilid
DTXCID80139968