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Ketamine

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Identification
Molecular formula
C13H16ClNO
CAS number
6740-88-1
IUPAC name
4-(dimethylamino)-1-[2-(2-phenylethyl)phenyl]butan-1-one
State
State

At room temperature, ketamine is typically found as a solid, especially in pharmaceutical applications, where it is usually provided in solution form for ease of administration in medical settings. When encountered as a illicit substance, it may be found as a powder or tablet.

Melting point (Celsius)
92.50
Melting point (Kelvin)
365.65
Boiling point (Celsius)
245.00
Boiling point (Kelvin)
518.15
General information
Molecular weight
237.34g/mol
Molar mass
237.3360g/mol
Density
1.0450g/cm3
Appearence

Ketamine appears as a colorless to off-white crystalline solid or powder. It is odorless or may have a slightly pungent odor and is often encountered in powdered form in illegal contexts.

Comment on solubility

Solubility of 4-(dimethylamino)-1-[2-(2-phenylethyl)phenyl]butan-1-one

The solubility of 4-(dimethylamino)-1-[2-(2-phenylethyl)phenyl]butan-1-one, a complex organic compound, is influenced by various factors, including its structure, polarity, and the presence of functional groups. Understanding its solubility characteristics is essential for applications in pharmaceuticals and material science.

Key Factors Affecting Solubility

  • Polarity: The presence of the dimethylamino group contributes to increased polarity, potentially enhancing solubility in polar solvents.
  • Hydrophobic Interactions: The phenyl groups in the structure may lead to hydrophobic interactions, which can limit solubility in water but enhance solubility in organic solvents.
  • Functional Groups: The interaction of the functional groups with solvents plays a significant role in determining whether the compound is soluble in organic or aqueous environments.

It is worth noting that solubility can vary significantly based on temperature and the solvent system used. As a general observation, compounds with a robust aromatic framework tend to exhibit limited solubility in water but show enhanced solubility in organic solvents like ethanol or DMSO when tested. Therefore, it is crucial to consider these factors when determining the solubility profile of this compound for practical applications.

In summary, the solubility of 4-(dimethylamino)-1-[2-(2-phenylethyl)phenyl]butan-1-one illustrates the intricate balance between various molecular interactions and highlights the importance of analyzing solubility in the context of its intended use.

Interesting facts

Interesting Facts about 4-(Dimethylamino)-1-[2-(2-phenylethyl)phenyl]butan-1-one

This intriguing compound, often referred to in the scientific community for its unique structural features, has generated interest due to its potential applications in various fields. Here are some noteworthy points:

  • Structural Complexity: The compound features a dimethylamino group, which is indicative of its potential interactions in biological systems. The presence of phenylethyl moieties adds an interesting layer of complexity, which can influence its pharmacological properties.
  • Pharmaceutical Implications: Compounds similar to 4-(dimethylamino)-1-[2-(2-phenylethyl)phenyl]butan-1-one are researched for their potential use in developing psychoactive drugs. The dimethylamino group may enhance lipophilicity, allowing better permeability across biological membranes.
  • Research Interest: Chemists are particularly fascinated by such derivatives due to their ability to mimic neurotransmitters and their potential use as analgesics or antidepressants. A quote often echoed in research circles is: "Small changes in chemical structure can lead to significant changes in biological activity." This is especially true for this compound.
  • Analytical Techniques: Characterizing this compound typically involves sophisticated techniques such as NMR spectroscopy and mass spectrometry, which elucidate its unique bonding and structural features. Understanding these properties is crucial for drug design.
  • Synthesis Considerations: The synthetic pathway leading to such complex compounds often involves multi-step reactions, challenging both chemists and researchers to optimize yield while ensuring purity. This complexity also adds to the excitement of synthesizing novel analogs for biological testing.

The exploration of 4-(dimethylamino)-1-[2-(2-phenylethyl)phenyl]butan-1-one not only highlights the fascinating intricacies of organic chemistry but also emphasizes the continuous evolution of medicinal chemistry as researchers strive to push the boundaries in drug design and discovery. As noted by many in the field, "The future of pharmacology lies in understanding the delicate dance of atoms and bonds."

Synonyms
5505-01-1
4-(dimethylamino)-1-[2-(2-phenylethyl)phenyl]butan-1-one
DTXSID90274753
4-DIMETHYLAMINO-1-(2-PHENETHYL-PHENYL)-BUTAN-1-ONE