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Erythromycin

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Identification
Molecular formula
C37H67NO13
CAS number
114-07-8
IUPAC name
[4-(dimethylamino)-2-[[14-ethyl-7,12,13-trihydroxy-4-(5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yl)oxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-oxacyclotetradec-6-yl]oxy]-6-methyl-tetrahydropyran-3-yl] propanoate
State
State

At room temperature, erythromycin is a solid. It is commonly encountered as a free base or in the form of salts, like erythromycin stearate or erythromycin ethylsuccinate, which can be solid oral dosage forms.

Melting point (Celsius)
135.00
Melting point (Kelvin)
408.15
Boiling point (Celsius)
229.00
Boiling point (Kelvin)
502.15
General information
Molecular weight
733.94g/mol
Molar mass
733.9380g/mol
Density
1.2880g/cm3
Appearence

Erythromycin is a white to off-white crystalline powder. It is known to be hygroscopic, meaning it can absorb moisture from the environment. The compound is often available in the form of tablets, capsules, or powders for oral or injectable use.

Comment on solubility

Solubility of 4-(Dimethylamino)-2-[[14-ethyl-7,12,13-trihydroxy-4-(5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yl)oxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-oxacyclotetradec-6-yl]oxy]-6-methyl-tetrahydropyran-3-yl propanoate (C37H67NO13)

The solubility of this compound in various solvents can be quite intriguing, owing to its complex structure. The solubility can be influenced by several factors:

  • Polarity: The presence of multiple hydroxyl (–OH) groups typically enhances solubility in polar solvents, like water.
  • Hydrophobic Regions: The long hydrocarbon chains, including methyl and other alkyl groups, may render the compound insoluble in water but soluble in organic solvents.
  • Temperature: Increasing the temperature may enhance solubility as it allows for greater molecular movement and interaction.
  • pH Levels: The ionization of functional groups may also affect solubility, especially in biological systems.

As stated, "Solubility is greatly influenced by the nature of the solute and the solvent." Therefore, while this compound may show some affinity for water due to its hydroxyl groups, it is likely more soluble in organic solvents such as ethanol or dimethyl sulfoxide (DMSO) due to its overall hydrophobic character.

The specific solubility characteristics of C37H67NO13 would necessitate empirical testing in various solvents under controlled conditions to yield definitive data.

Interesting facts

Interesting Facts about 4-(Dimethylamino)-2-[[14-ethyl-7,12,13-trihydroxy-4-(5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yl)oxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-oxacyclotetradec-6-yl]oxy]-6-methyl-tetrahydropyran-3-yl Propanoate

This compound is a fascinating member of the class of molecules known as tetrahydropyran derivatives. These compounds are widely studied for their potential applications in pharmaceuticals and organic synthesis. Here are some key points that highlight its significance:

  • Structural Complexity: With its intricate structure, this compound showcases a complex arrangement of functional groups, including hydroxyl groups and ether linkages, making it a prime candidate for research in medicinal chemistry.
  • Potential Biological Activity: The presence of multiple hydroxyl groups often indicates potential interactions with biological systems, which can enhance solubility and biological availability, attracting interest in drug development.
  • Natural Product Inspiration: Many tetrahydropyran compounds are derived from natural products, which often exhibit biological activities, including antibacterial and antiviral properties, thus offering a rich source for the development of new medicines.
  • Customizable Framework: The chemical structure enables easy modifications, allowing scientists to create variations that can lead to even more effective therapeutic agents.
  • Research Applications: This compound could be utilized in exploring structures that mimic natural compounds, aiding in the design of drugs that interact with specific biological targets.

As stated by chemist Robert H. Grubbs, "The more complex the structure, the greater the potential for unique properties." This aligns perfectly with the unique intricacies found in this compound, which exemplifies the beauty of organic chemistry!

In summary, the compound 4-(dimethylamino)-2-[[14-ethyl-7,12,13-trihydroxy-4-(5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yl)oxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-oxacyclotetradec-6-yl]oxy]-6-methyl-tetrahydropyran-3-yl propanoate serves as a significant example of how nature's complexity can inspire innovative approaches in the field of chemistry. Its detailed study may lead to new discoveries in both academic and applied science. With continued research, who knows what breakthroughs await!

Synonyms
CHEMBL4744799
DTXSID90859266
AAA13436
STK177308
AKOS005410740
DB-042233
H-pyran-3-yl propanoate (non-preferred name)
4-(Dimethylamino)-2-({14-ethyl-7,12,13-trihydroxy-4-[(5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl)oxy]-3,5,7,9,11,13-hexamethyl-2,10-dioxo-1-oxacyclotetradecan-6-yl}oxy)-6-methyloxan-3-yl propanoate