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Verapamil

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Identification
Molecular formula
C27H38N2O4
CAS number
52-53-9
IUPAC name
4-(dimethylamino)-2-[2-(dimethylamino)ethyl]-2-(1-naphthyl)butanenitrile
State
State

At room temperature, Verapamil is typically a solid with a crystalline structure.

Melting point (Celsius)
143.00
Melting point (Kelvin)
416.15
Boiling point (Celsius)
586.00
Boiling point (Kelvin)
859.15
General information
Molecular weight
454.61g/mol
Molar mass
454.6050g/mol
Density
1.0753g/cm3
Appearence

Verapamil is a white crystalline powder. It is odorless and has a bitter taste.

Comment on solubility

Solubility of 4-(dimethylamino)-2-[2-(dimethylamino)ethyl]-2-(1-naphthyl)butanenitrile

The solubility of 4-(dimethylamino)-2-[2-(dimethylamino)ethyl]-2-(1-naphthyl)butanenitrile can be influenced by several factors due to its complex molecular structure and functional groups. Here are some key points to consider:

  • Type of solvent: This compound is likely to exhibit significant solubility in polar organic solvents such as methanol and ethanol, due to the presence of the dimethylamino groups which can engage in hydrogen bonding.
  • Hydrophilic and hydrophobic balance: The compound contains both lipophilic (naphthyl group) and hydrophilic (dimethylamino groups) components which may affect its solubility in water. Its overall hydrophobic character hints at lower solubility in aqueous environments.
  • Temperature dependency: As with many organic compounds, a change in temperature can significantly influence solubility; generally, increased temperature tends to increase solubility in liquids.
  • pH dependence: The solubility may also vary with the pH of the solution, particularly due to the basic nature of the dimethylamino groups that could become protonated under acidic conditions, enhancing solubility.

In conclusion, while 4-(dimethylamino)-2-[2-(dimethylamino)ethyl]-2-(1-naphthyl)butanenitrile shows promise for solubility in organic solvents, the specific solubility characteristics will ultimately depend on a blend of factors including solvent type, temperature, and pH. Understanding these interactions is essential for optimizing the use of this compound in various applications.

Interesting facts

Interesting Facts About 4-(dimethylamino)-2-[2-(dimethylamino)ethyl]-2-(1-naphthyl)butanenitrile

This compound, with its intricate molecular structure, serves as a fascinating subject of study in the field of organic chemistry. Here are several noteworthy aspects of this compound:

  • Biological Relevance: Compounds similar in structure are often explored for their potential biological activities, including antitumor and antifungal properties.
  • Dimethylamino Groups: The presence of dimethylamino groups in this molecule enhances its capacity for nucleophilic substitution reactions, making it a versatile building block in organic synthesis.
  • Naphthyl Moiety: The incorporation of the naphthyl group contributes aromatic character, which is important in modulating the compound's physical properties and reactivity.
  • Synthetic Utility: This complex structure represents the potential for sophisticated synthesis methodologies that combine multiple functional groups, ideal for developing new pharmaceuticals or agrochemicals.
  • Research Applications: Its unique structure draws attention in research settings, particularly in studies involving receptor binding and pharmaceutical efficacy.

The compound stands out due to its chemical complexity, providing a rich canvas for exploration in both academic and industrial chemistry. As chemists continue to investigate the interactions and functionalities of compounds like this, the potential discoveries may pave the way for innovative applications across various fields.

Synonyms
2810-20-0
BRN 2155095
1-NAPHTHALENEACETONITRILE, alpha,alpha-BIS(2-(DIMETHYLAMINO)ETHYL)-
alpha,alpha-Bis(2-(dimethylamino)ethyl)-1-naphthaleneacetonitrile
DTXSID70182382
DTXCID80104873
1-Naphthaleneacetonitrile,alpha,alpha-bis(2-(dimethylamino)ethyl)-