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Naproxen

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Identification
Molecular formula
C14H14O3
CAS number
22204-53-1
IUPAC name
4-(dimethylamino)-2-[2-(dimethylamino)ethyl]-2-(1-naphthyl)butanoic acid
State
State

At room temperature, naproxen is in a solid state. It exists either as a crystalline powder or granules, making it suitable for use in pharmaceutical formulations including tablets and capsules.

Melting point (Celsius)
153.00
Melting point (Kelvin)
426.15
Boiling point (Celsius)
360.00
Boiling point (Kelvin)
633.15
General information
Molecular weight
230.32g/mol
Molar mass
230.3200g/mol
Density
1.1460g/cm3
Appearence

Naproxen typically appears as a white to off-white crystalline substance. It can be in the form of powder or crystalline granules. The compound is known for its stability under normal conditions of temperature and pressure.

Comment on solubility

Solubility of 4-(dimethylamino)-2-[2-(dimethylamino)ethyl]-2-(1-naphthyl)butanoic acid

The solubility of 4-(dimethylamino)-2-[2-(dimethylamino)ethyl]-2-(1-naphthyl)butanoic acid, often referred to with its shorthand, can be quite complex due to its intricate structure. This compound is known for its unique properties stemming from the presence of multiple functional groups, which influence its solubility in various solvents.

Key Points to Consider:

  • Polarity: The presence of the dimethylamino groups increases the overall polarity of the molecule, which can enhance solubility in polar solvents like water.
  • Hydrophobic Nature: The attached naphthyl moiety contributes a hydrophobic character that may limit solubility in polar substances.
  • pH Dependence: The acidic group in this compound can also affect solubility based on the pH of the solution, as protonation states can alter its solubility profile.
  • Solvent Selection: While it may dissolve well in solvents such as ethyl acetate or methanol, the extent of its solubility can vary greatly when tested in dimethyl sulfoxide (DMSO) or acidic versus basic mediums.

To summarize, the solubility of 4-(dimethylamino)-2-[2-(dimethylamino)ethyl]-2-(1-naphthyl)butanoic acid is governed by a combination of polar and non-polar interactions, pH levels, and the choice of solvent. Therefore, understanding these factors is crucial for effectively utilizing this compound in various applications.

Interesting facts

Interesting Facts about 4-(dimethylamino)-2-[2-(dimethylamino)ethyl]-2-(1-naphthyl)butanoic acid

This intriguing compound, often referred to in scientific literature, showcases the fascinating interplay of organic chemistry and medicinal applications. Below are some notable points that highlight its significance:

  • Structure and Complexity: The compound features a complex structure with multiple functional groups, including dimethylamino and naphthyl components. This complexity can lead to interesting interactions in biological systems.
  • Pharmacological Potential: Its unique structure suggests potential use in the field of pharmaceuticals, particularly as a prototype for developing novel drugs, possibly in managing certain neurochemical disorders.
  • Research Applications: Many studies explore compounds like this within the realms of neuroscience and pharmacology, as they can influence neurotransmitter activities, thus potentially aiding in treating conditions such as depression and anxiety.
  • Development of Analogs: Chemists are often interested in creating analogs of such molecules to optimize their efficacy and minimize side effects. The study of such analogs can lead to breakthroughs in medicinal chemistry.
  • Cyclic and Non-Cyclic Interactions: The presence of naphthalene in the structure can suggest interactions with various receptors due to its aromatic nature, leading to expected diverse bioactivity.

As impressive as its potential is, the thorough understanding of its interactions at the molecular level is crucial for maximizing its benefits while minimizing any possible adverse effects. As research continues to unfold, compounds like 4-(dimethylamino)-2-[2-(dimethylamino)ethyl]-2-(1-naphthyl)butanoic acid remain at the forefront of chemical inquiry and innovation.