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Erythromycin A

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Identification
Molecular formula
C37H67NO13
CAS number
114-07-8
IUPAC name
[4-(dimethylamino)-2-[[(3R,4S,6R,7R,9R,11R,12R,13S,14R)-14-ethyl-7,12,13-trihydroxy-4-(5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yl)oxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-oxacyclotetradec-6-yl]oxy]-6-methyl-tetrahydropyran-3-yl] propanoate;dodecyl hydrogen sulfate
State
State
The compound is typically in a solid state at room temperature, appearing as a crystalline powder.
Melting point (Celsius)
135.00
Melting point (Kelvin)
408.15
Boiling point (Celsius)
318.00
Boiling point (Kelvin)
591.15
General information
Molecular weight
733.94g/mol
Molar mass
733.9360g/mol
Density
1.0983g/cm3
Appearence

White or slightly yellow crystalline powder. It is often provided in the form of a white to off-white crystalline powder for pharmaceutical applications.

Comment on solubility

Solubility of 4-(dimethylamino)-2-[[[3R,4S,6R,7R,9R,11R,12R,13S,14R)-14-ethyl-7,12,13-trihydroxy-4-(5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yl)oxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-oxacyclotetradec-6-yl]oxy]-6-methyl-tetrahydropyran-3-yl] propanoate; dodecyl hydrogen sulfate

The solubility of this intricate compound is influenced by its complex structure and functional groups. Various factors contribute to its solubility profile, including:

  • Polarity: The presence of multiple hydroxyl groups may enhance hydrogen bonding, potentially increasing solubility in polar solvents like water.
  • Hydrophobic Regions: The dodecyl group, being hydrophobic, could hinder solubility in water but might favor solubility in organic solvents.
  • Temperature: Increased temperature could facilitate solubility by providing kinetic energy to overcome molecular interactions.

In summary, the solubility of this compound is likely to be:

  1. Greater in polar solvents due to hydrogen bonding capabilities.
  2. Lower in non-polar solvents due to the balance of hydrophobic interactions.
  3. Temperature-dependent, with possible improved solubility at elevated temperatures.

Understanding the solubility of such a compound is crucial for its application in various fields, highlighting the importance of solvent choice in experimental protocols.

Interesting facts

Interesting Facts about 4-(Dimethylamino)-2-[[3R,4S,6R,7R,9R,11R,12R,13S,14R)-14-ethyl-7,12,13-trihydroxy-4-(5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yl)oxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-oxacyclotetradec-6-yl]oxy]-6-methyl-tetrahydropyran-3-yl propanoate; Dodecyl Hydrogen Sulfate

This compound is a fascinating example of structural complexity in the realm of organic chemistry. Here are some intriguing aspects that highlight its significance:

  • Pharmacological Importance: The compound is often studied for its potential pharmacological applications. Its unique structural properties might facilitate interactions with biological targets.
  • Natural Product Derivative: This compound is closely related to certain natural products, which makes it a candidate for research into alternative synthesis of bioactive molecules.
  • Synthetic Challenges: The synthesis of such complex organic compounds requires sophisticated techniques and multi-step processes, showcasing the ingenuity of synthetic organic chemists.
  • Mechanistic Studies: Investigations into how this compound interacts with other molecules can pave the way for understanding reaction mechanisms and guiding future compound modifications.
  • Applications in Material Science: Due to its unique molecular architecture, this compound also shows potential in the development of novel materials, such as sensors and polymers.

As expressed by many chemists, "The beauty of organic chemistry lies in the complexity and diversity of structures that can be synthesized and their potential impact on various fields." Exploring such compounds not only broadens our understanding of chemistry but also enhances our capability to innovate in medical and material sciences.

In summary, the study of 4-(Dimethylamino)-2-[[3R,4S,6R,7R,9R,11R,12R,13S,14R)-14-ethyl-7,12,13-trihydroxy-4-(5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yl)oxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-oxacyclotetradec-6-yl]oxy]-6-methyl-tetrahydropyran-3-yl propanoate; Dodecyl Hydrogen Sulfate exemplifies the intricate relationship between structure and function in chemistry, making it a vital subject for ongoing research.

Synonyms
Eromycin
[4-(dimethylamino)-2-[[(3R,4S,6R,7R,9R,11R,12R,13S,14R)-14-ethyl-7,12,13-trihydroxy-4-(5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl)oxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-oxacyclotetradec-6-yl]oxy]-6-methyloxan-3-yl] propanoate;dodecyl hydrogen sulfate
Erythromycin 2'-propanoate dodecyl sulfate (salt)
[4-(dimethylamino)-2-[[(3R,4S,6R,7R,9R,11R,12R,13S,14R)-14-ethyl-7,12,13-trihydroxy-4-(5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yl)oxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-oxacyclotetradec-6-yl]oxy]-6-methyl-tetrahydropyran-3-yl] propanoate; dodecyl hydrogen sulfate