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Lidocaine

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Identification
Molecular formula
C14H22N2O
CAS number
137-58-6
IUPAC name
4-(dimethylamino)-2,2-diphenyl-pentanamide
State
State

At room temperature, lidocaine is a solid. It is generally available in the form of a crystalline powder, but can also be found in solutions for injections and topical applications.

Melting point (Celsius)
66.00
Melting point (Kelvin)
339.15
Boiling point (Celsius)
350.80
Boiling point (Kelvin)
623.95
General information
Molecular weight
234.34g/mol
Molar mass
234.3420g/mol
Density
1.0260g/cm3
Appearence

Lidocaine appears as a white crystalline powder, which is odorless or almost odorless. It is soluble in water and alcohol and is often used in its hydrochloride form for medical applications.

Comment on solubility

Solubility of 4-(dimethylamino)-2,2-diphenyl-pentanamide

The solubility of 4-(dimethylamino)-2,2-diphenyl-pentanamide, often referred to by its shorthand name in scientific circles, presents interesting characteristics due to its unique structure. This compound has a moderate solubility profile influenced by several factors:

  • Polarity: The presence of the dimethylamino group significantly affects the polarity of the molecule, potentially increasing its solubility in polar solvents.
  • Hydrophobic Regions: The two phenyl rings contribute to the hydrophobic character, which may lead to limited solubility in water but enhanced solubility in organic solvents such as alcohols and dimethyl sulfoxide (DMSO).
  • pH Dependency: The solubility can be affected by pH—higher pH can help in ionizing the amide group, potentially increasing solubility.

In summary, the solubility of this compound can be described as:

  1. **Moderate in polar solvents** (e.g., water with adjustments in pH).
  2. **Higher in organic solvents** (e.g., ethanol, methanol).
  3. **Dependent on temperature** (increased temperature can often enhance solubility).

It is essential to consider these factors if one is to work with this compound in various chemical contexts. As always, practical experimentation is recommended to ascertain precise solubility properties under specific conditions.

Interesting facts

4-(Dimethylamino)-2,2-diphenyl-pentanamide

This fascinating compound, often referred to in literature as an amide, possesses unique structural characteristics that make it of interest in various fields, including pharmaceuticals and organic chemistry. Here are some intriguing aspects of 4-(dimethylamino)-2,2-diphenyl-pentanamide:

  • Pharmacological Interest: This compound may act as a ligand in biological systems, potentially influencing neurotransmitter activity, leading to research implications in drug design targeting central nervous system disorders.
  • Synthetic Routes: Chemists often explore diverse synthetic methods to obtain this compound, showcasing its versatility and the ingenuity required to manipulate amide functionalities in organic synthesis.
  • Structure-Activity Relationship (SAR): The dimethylamino group attached to the compound plays a vital role in modulating its biological properties, making it a valuable compound for studying SAR in medicinal chemistry.
  • Applications in Dyes: Variations of this compound structure may contribute to the synthesis of dyes, adding color to materials through intricate chemical reactions.

Additionally, the presence of both diphenyl and pentanamide functionalities introduces complexity in conformational analysis. Scientists often utilize techniques such as NMR and X-ray crystallography to elucidate the spatial arrangement of atoms.

In summary, 4-(dimethylamino)-2,2-diphenyl-pentanamide is not just a simple compound but a representation of the intersection between organic chemistry and pharmacology, with implications that extend into various scientific domains. As one researcher noted, "The beauty of amides lies in their dual nature: they are both simple and intricate, unlocking a universe of possibilities."

Synonyms
Aminopentamide
Dimevamide
60-46-8
Dimevamida
Valeramide-OM
Dimevamidum
dl-Aminopentamide
UNII-IP1B47L61M
BL-139
4-Dimethylamino-2,2-diphenylvaleramide
IP1B47L61M
Dimevamidum [INN-Latin]
EINECS 200-479-8
BL 139
Dimevamida [INN-Spanish]
NSC-759162
DTXSID2057605
Valeramide, 4-(dimethylamino)-2,2-diphenyl-
alpha,alpha-Diphenyl-gamma-dimethylaminovaleramide
NSC 759162
Benzeneacetamide, alpha-(2-(dimethylamino)propyl)-alpha-phenyl-
Dimevamidum (INN-Latin)
Dimevamida (INN-Spanish)
DIMEVAMIDE (MART.)
DIMEVAMIDE [MART.]
alpha-(2-(Dimethylamino)propyl)-alpha-phenylbenzeneacetamide
DTXCID0031394
200-479-8
4-(dimethylamino)-2,2-diphenylpentanamide
Dimevamide [INN]
Dimevamide, (+)-
Dimevamide, (-)-
Centrine, (+)-
Centrine, (-)-
Aminopentamide, (+)-
Aminopentamide, (-)-
HI3DVH9WMI
Valeramide-om, (+)-
Valeramide-om, (-)-
661TMO8UM4
BL-139, (+)-
BL-139, (-)-
6078-64-4
Valeramide, 4-(dimethylamino)-2,2-diphenyl-, (+)-
Valeramide, 4-(dimethylamino)-2,2-diphenyl-, (-)-
BL 139; Centrine; Dimevamide; Valeramide-OM; dl-Aminopentamide
aminopentamide hydrogen sulfate
5985-88-6
AMINOPENTAMIDE SULFATE (200 MG)
Dimevamid
UNII-HI3DVH9WMI
AMINOPENTAMIDE [MI]
DIMEVAMIDE [WHO-DD]
UNII-661TMO8UM4
CHEMBL92915
SCHEMBL251458
Aminopentamide sulfate(200 mg)
CHEBI:91829
NARHAGIVSFTMIG-UHFFFAOYSA-N
BCP32413
MFCD00865194
DB15597
SBI-0206820.P001
NS00034359
NS00123668
F20770
AB01563100_01
BRD-A69917777-065-01-4
BRD-A69917777-065-02-2
Q27163625
alpha,alpha-Diphenyl-gamma-dimethylaminovaleramide, (-)-
Dimevamida;4-Dimethylamino-2,2-diphenylva-leramide;BL-139
.ALPHA.,.ALPHA.-DIPHENYL-.GAMMA.-DIMETHYLAMINOVALERAMIDE, (-)-
.ALPHA.-(2-(DIMETHYLAMINO)PROPYL)-.ALPHA.-PHENYLBENZENEACETAMIDE
BENZENEACETAMIDE, .ALPHA.-(2-(DIMETHYLAMINO)PROPYL)-.ALPHA.-PHENYL-
Benzeneacetamide, alpha-(2-(dimethylamino)propyl)-alpha-phenyl-, (+)-
BENZENEACETAMIDE, .ALPHA.-(2-(DIMETHYLAMINO)PROPYL)-.ALPHA.-PHENYL-, (+)-