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Methadone

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Identification
Molecular formula
C21H27NO
CAS number
76-99-3
IUPAC name
4-(dimethylamino)-2,2-diphenyl-pentanenitrile
State
State

Methadone is generally encountered in the form of its hydrochloride salt as a solid. In its pure form, it can be a colorless crystalline powder.

Melting point (Celsius)
233.00
Melting point (Kelvin)
506.15
Boiling point (Celsius)
168.00
Boiling point (Kelvin)
441.15
General information
Molecular weight
309.45g/mol
Molar mass
309.4510g/mol
Density
0.9787g/cm3
Appearence

Methadone is typically used in its hydrochloride salt form when prepared for medical use, which is a white, crystalline powder. The base form has a more waxy-like appearance.

Comment on solubility

Solubility of 4-(dimethylamino)-2,2-diphenyl-pentanenitrile

The solubility of 4-(dimethylamino)-2,2-diphenyl-pentanenitrile is influenced by several factors, primarily its molecular structure and polarity. Here are some key points to consider:

  • Polarity: The presence of the dimethylamino group can enhance the polar nature of the compound, which typically increases solubility in polar solvents like water.
  • Hydrophobic Regions: The diphenyl groups contribute significantly to hydrophobic characteristics, suggesting that the compound may also exhibit enhanced solubility in non-polar solvents such as organic solvents.
  • Solvent Compatibility: It is likely to show considerable solubility in solvents such as ethanol and acetone, while displaying lower solubility in hydrocarbons.
  • Temperature Dependence: Like many organic compounds, solubility may increase with temperature, making heat an important factor in dissolving this compound.

In summary, one could expect that 4-(dimethylamino)-2,2-diphenyl-pentanenitrile is moderately soluble in polar solvents while also being soluble in various organic solvents, especially those that are less polar. This dual solubility enhances its versatility for various applications in both research and industry.

Interesting facts

Interesting Facts about 4-(Dimethylamino)-2,2-diphenyl-pentanenitrile

4-(Dimethylamino)-2,2-diphenyl-pentanenitrile, commonly referred to in the scientific community for its unique properties and applications, is a fascinating compound worth exploring. Here are some intriguing aspects:

  • Origin of Name: The name of this compound provides insight into its structure. The "dimethylamino" part indicates the presence of a dimethylamine group, which is known to influence the compound's reactivity and solubility.
  • Structural Features: This compound consists of a pentanenitrile backbone, flanked by two phenyl groups. Its bulky structure is responsible for interesting chemical behavior and interactions with other molecules.
  • Biological Activity: Compounds containing dimethylamino groups often exhibit pharmacological activities. Research into related compounds suggests potential applications in medicinal chemistry, particularly in the development of new pharmaceuticals.
  • Colorimetric Applications: Research shows that compounds similar to 4-(dimethylamino)-2,2-diphenyl-pentanenitrile can be used as colorimetric probes, allowing for visual detection of various analytes in analytical chemistry.
  • Electron Donor Potential: The dimethylamino group can act as an electron donor, making the compound a candidate for studies in organic electronics and as a ligand in coordination chemistry.

As we delve deeper into the study of chemical compounds like 4-(dimethylamino)-2,2-diphenyl-pentanenitrile, we uncover their potential impact in various fields, ranging from synthetic chemistry to biochemistry. The diversity and complexity of organic molecules continue to inspire ongoing research and innovation.

Synonyms
Methadone intermediate
Premethadone
Didiavalo
4-(Dimethylamino)-2,2-diphenylvaleronitrile
Premethadon
4-Dimethylamino-2,2-diphenylvaleronitrile
2,2-Diphenyl-4-(dimethylamino)valeronitrile
Methadon-zwischenprodukt
2,2-Diphenyl-4-dimethylaminovaleronitrile
NSC 2089
0GYB2HJA89
DTXSID1048912
NSC-2089
EINECS 204-755-9
NSC-50382
IDS-NM-003
4-cyano-2-dimethylamino-4,4-diphenyl butane
DTXCID4028838
Valeronitrile, 4-(dimethylamino)-2,2-diphenyl-
Benzeneacetonitrile, alpha-(2-(dimethylamino)propyl)-alpha-phenyl-
(4RS)-4-(Dimethylamino)-2,2-diphenylpentanenitrile
METHADONE HYDROCHLORIDE IMPURITY B [EP IMPURITY]
LEVOMETHADONE HYDROCHLORIDE IMPURITY B [EP IMPURITY]
Benzeneacetonitrile, .alpha.-[2-(dimethylamino)propyl]-.alpha.-phenyl-
METHADONE-INTERMEDIATE, 4-CYANO-2-DIMETHYLAMINO-4,4-DIPHENYL BUTANE
BENZENEACETONITRILE, .ALPHA.-(2-(DIMETHYLAMINO)PROPYL)-.ALPHA.-PHENYL-
METHADONE HYDROCHLORIDE IMPURITY B (EP IMPURITY)
LEVOMETHADONE HYDROCHLORIDE IMPURITY B (EP IMPURITY)
RefChem:586923
DIDIAVALO, (+-)-
Valeronitrile, 4-(dimethylamino)-2,2-diphenyl-(8CI)
Benzeneacetonitrile, alpha-(2-(dimethylamino)propyl)-alpha-phenyl-(9CI)
125-79-1
4-(Dimethylamino)-2,2-diphenylpentanenitrile
EINECS 278-172-3
(1)-4-(Dimethylamino)-2,2-diphenylpentanonitrile
NCGC00247341-02
Valeronitrile,2-diphenyl-
75281-86-6
Methadone intermediate (1mg/ml in Acetonitrile)
UNII-0GYB2HJA89
NSC2089
(4RS)-4-(Dimethylamino)-2,2-diphenylpentanenitrile (Didiavalo; Premethadone; Methadone Nitrile)
2,2-Diphenyl-4-dimethylaminopentanenitrile
4-cyano-2-dimethylamino-4,4-diphenylbutane
METHADONE-INTERMEDIATE
MLS002320724
SCHEMBL504205
DEA No. 9254
CHEMBL2362721
DIDIAVALO, (+/-)-
HMS2272J04
NSC50382
Tox21_112859
MFCD00068847
AKOS025392613
BS-5037
NCGC00247341-01
CAS-125-79-1
SMR001338870
4-dimethylamino-2,2-diphenylpentanenitrile
NS00024031
4-(dimethylamino)-2,2-diphenyl-pentanenitrile
C22686
4-(Dimethylamino)-2,2-diphenylpentanenitrile #
butane, 1-cyano-3-dimethylamino-1,1-diphenyl-
(+/-)-4-Dimethylamino-2,2-diphenylvaleronitrile
Q12470029
propane, 1-cyano-3-dimethylamino-3-methyl-1,1-diphenyl-
4-Cyano-2-dimethylamino-4,4-diphenylbutane (methadone-intermediate)