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Methadone

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Identification
Molecular formula
C21H27NO
CAS number
76-99-3
IUPAC name
4-(dimethylamino)-3-methyl-1,2-diphenyl-butan-2-ol
State
State

At room temperature, Methadone is generally found as a solid powder, though it is commonly dissolved in a liquid for pharmaceutical applications.

Melting point (Celsius)
233.00
Melting point (Kelvin)
506.15
Boiling point (Celsius)
215.00
Boiling point (Kelvin)
488.15
General information
Molecular weight
309.45g/mol
Molar mass
309.4510g/mol
Density
0.8700g/cm3
Appearence

Methadone is typically present as a colorless crystalline powder. It may appear in a liquid form when used in pharmaceutical solutions.

Comment on solubility

Solubility of 4-(Dimethylamino)-3-methyl-1,2-diphenyl-butan-2-ol (C21H27NO)

The solubility of 4-(dimethylamino)-3-methyl-1,2-diphenyl-butan-2-ol, often referred to as a tertiary alcohol, can be impacted by several factors, primarily its chemical structure and the presence of polar and non-polar functional groups.

In general, the solubility characteristics of this compound can be summarized as follows:

  • Polar Nature: The dimethylamino group contributes some polarity to the molecule, which can lead to increased solubility in polar solvents such as water.
  • Hydrophobic Regions: The presence of multiple phenyl rings introduces significant hydrophobic characteristics, suggesting that this compound may have limited solubility in highly polar solvents.
  • Organic Solvents: It is likely to be more soluble in organic solvents like ethanol, methanol, and certain non-polar solvents due to its overall hydrophobic nature.
  • Temperature Effects: As with many organic compounds, increasing the temperature may enhance solubility, particularly in organic solvents.

In summary, while 4-(dimethylamino)-3-methyl-1,2-diphenyl-butan-2-ol shows varying degrees of solubility depending on the solvent used, it is essential to consider the balance of its polar and non-polar characteristics when predicting its solubility. According to the principle of “like dissolves like,” this compound is expected to exhibit better solubility in organic solvents compared to water.

Interesting facts

Interesting Facts About 4-(Dimethylamino)-3-methyl-1,2-diphenyl-butan-2-ol

4-(Dimethylamino)-3-methyl-1,2-diphenyl-butan-2-ol is a fascinating compound that belongs to the family of β-phenyl-β-amino alcohols. Here are some engaging insights into this compound:

  • Unique Structure: The compound features an intricate structure characterized by a combination of aromatic and aliphatic components, which may contribute to its interesting solubility properties and potential reactivity.
  • Applications in Medicine: Compounds like this one can serve as precursors in the synthesis of pharmaceuticals, particularly due to their ability to interact with biological systems. They may have implications in the development of medications targeting neurological and psychiatric disorders.
  • Importance of the Dimethylamino Group: The presence of a dimethylamino moiety is crucial, as it enhances the lipophilicity of the compound, potentially improving its ability to cross biological membranes and reach active sites within organisms.
  • Synthesis Explorations: The synthesis of this compound often involves multi-step synthetic pathways that can integrate various reagents and conditions, making it a point of interest for synthetic chemists.
  • Chirality: As a chiral molecule, 4-(dimethylamino)-3-methyl-1,2-diphenyl-butan-2-ol can exist in multiple enantiomeric forms, which can lead to different biological activity profiles. Understanding these interactions is pivotal in drug design and development.

In summary, 4-(dimethylamino)-3-methyl-1,2-diphenyl-butan-2-ol plays a significant role in the field of organic chemistry and pharmaceutical development. Its unique structural and chemical properties invite further exploration into its potential uses and effects in biological contexts.

Synonyms
4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-ol
Benzeneethanol, .alpha.-[2-(dimethylamino)-1-methylethyl]-.alpha.-phenyl-
2214-28-0
Benzeneethanol, .alpha.-[2-(dimethylamino)-1-methylethyl]-.alpha.-phenyl-, [S-(R*,S*)]-
SCHEMBL5419272
DTXSID90865908
CHEBI:192139
AKOS024307465
DB-069682
NS00041229
NS00122281
4-(Dimethylamino)-3-methyl-1,2-diphenyl-2-butanol #
(+)-(2S,3R)-4-Dimethylamino-3-methyl-1,2-diphenyl-2-butanol
Benzeneethanol, alpha-(2-(dimethylamino)-1-methylethyl)-alpha-phenyl-, (S-(R*,S*))-