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Coumarin

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Identification
Molecular formula
C12H9NO3
CAS number
61446-64-6
IUPAC name
4-(ethoxymethylene)-2-phenyl-oxazol-5-one
State
State

Solid at room temperature.

Melting point (Celsius)
143.00
Melting point (Kelvin)
416.15
Boiling point (Celsius)
398.00
Boiling point (Kelvin)
671.15
General information
Molecular weight
213.21g/mol
Molar mass
213.2050g/mol
Density
1.4120g/cm3
Appearence

4-(Ethoxymethylene)-2-phenyl-oxazol-5-one typically appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 4-(ethoxymethylene)-2-phenyl-oxazol-5-one

The solubility of 4-(ethoxymethylene)-2-phenyl-oxazol-5-one can be considered in a few distinct contexts, particularly in relation to solvents and the chemical's overall properties. The compound's unique structure suggests that it may exhibit varying solubility characteristics depending on the medium used.

Generally, the solubility of organic compounds like 4-(ethoxymethylene)-2-phenyl-oxazol-5-one can be influenced by factors such as:

  • Polarity: The presence of ethoxy and phenyl groups can create a balance between polar and non-polar characteristics, potentially making it soluble in both polar and non-polar solvents.
  • Hydrogen bonding: The oxazole ring may participate in hydrogen bonding, which can enhance solubility in polar solvents like water or alcohol.
  • Structural interactions: The interactions between the compound and the solvent molecules can significantly affect solubility. For instance, hydrogen bond donors and acceptors in the solvent can solvate the compound effectively.

In general:

  • If tested in non-polar solvents (e.g., hexane), you might find low solubility due to the lack of favorable interactions.
  • In polar protic solvents (e.g., ethanol), enhanced solubility is likely due to hydrogen bonding and dipole-dipole interactions.

As such, despite the lack of extensive solubility data specifically for 4-(ethoxymethylene)-2-phenyl-oxazol-5-one, one can postulate that it may dissolve effectively in organic solvents while also having reasonable solubility in polar environments. Testing in various solvents would be necessary to determine precise solubility parameters.

Interesting facts

Interesting Facts about 4-(ethoxymethylene)-2-phenyl-oxazol-5-one

4-(ethoxymethylene)-2-phenyl-oxazol-5-one is a fascinating compound that showcases the intricate relationship between structure and reactivity in organic chemistry. This compound belongs to the oxazole family, which is known for its diverse applications in fields ranging from medicinal chemistry to materials science. Here are some intriguing aspects of this compound:

  • Structural Diversity: The unique oxazol-5-one backbone provides a platform for various substituents, allowing the compound to display a range of chemical properties. The presence of the ethoxymethylene group enhances its reactivity and potential applications.
  • Biological Activity: Compounds with oxazole rings are often investigated for their biological properties. Research has shown that oxazoles can exhibit anti-inflammatory, antimicrobial, and anticancer activities, making them valuable in drug discovery.
  • Fluorescent Properties: Some oxazole derivatives demonstrate interesting photophysical properties, including fluorescence. This can be exploited in imaging techniques and in the development of sensors.
  • Synthesis Potential: The synthesis of 4-(ethoxymethylene)-2-phenyl-oxazol-5-one can involve various methods, such as reaction of 2-phenyl-oxazol-5-one with ethyl formate, illustrating the importance of reaction conditions and reactant choice in organic synthesis.
  • Interdisciplinary Connections: This compound connects chemistry with multiple disciplines, including biology, medicine, and materials science. Its study reflects the interdisciplinary nature of modern scientific research.

In summary, 4-(ethoxymethylene)-2-phenyl-oxazol-5-one is not only an interesting compound in terms of its structure and reactivity but also highlights broader themes in chemical research and innovation. As quoted by a prominent chemist, “The beauty of chemistry lies in its ability to transform the mundane into the magnificent,” and this compound is a perfect representation of that idea.

Synonyms
4-Ethoxymethylene-2-phenyl-2-oxazolin-5-one
4-Ethoxymethylene-2-phenyl-2-oxazoline-5-one
4-(ethoxymethylene)-2-phenyloxazol-5(4H)-one
CHEBI:53076
(4E)-4-(ethoxymethylene)-2-phenyl-1,3-oxazol-5(4H)-one
Epitope ID:112743
SCHEMBL25034
4-(ethoxymethylidene)-2-phenyl-1,3-oxazol-5-one
orb1302095
SJHPCNCNNSSLPL-UHFFFAOYSA-N
OXA
MFCD03225480
AKOS037515636
4-(ethoxymethylene)-2-phenyl-oxazol-5-one
DB-043321