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Phenazone

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Identification
Molecular formula
C11H12N2O1
CAS number
60-80-0
IUPAC name
4-ethyl-2-(1-methyl-4-piperidyl)-5-phenyl-1H-pyrazol-3-one
State
State

At room temperature, Phenazone is in a solid state, typically as a powder. It is stable under normal conditions and is used in various medical formulations.

Melting point (Celsius)
156.00
Melting point (Kelvin)
429.15
Boiling point (Celsius)
320.00
Boiling point (Kelvin)
593.15
General information
Molecular weight
188.23g/mol
Molar mass
188.2290g/mol
Density
1.2976g/cm3
Appearence

Phenazone appears as a white or almost white crystalline powder. It is often used in pharmaceutical applications, making its visibility in solid dosage forms important. The compound has a slightly bitter taste.

Comment on solubility

Solubility of 4-ethyl-2-(1-methyl-4-piperidyl)-5-phenyl-1H-pyrazol-3-one

The solubility of 4-ethyl-2-(1-methyl-4-piperidyl)-5-phenyl-1H-pyrazol-3-one is influenced by various factors, making it an interesting compound from a solubility perspective. Here are some key points to consider:

  • Polarity: The presence of different substituents, such as the ethyl group and the piperidyl moiety, affects the molecule's polarity. This can impact its solubility in polar versus non-polar solvents.
  • Hydrogen Bonding: This compound has the potential to engage in hydrogen bonding due to its functional groups. Hydrogen bonding can enhance solubility in polar solvents.
  • Solvent Compatibility: It tends to be more soluble in organic solvents compared to water. Common organic solvents used for its solubility testing include:
    • DMSO (Dimethyl sulfoxide)
    • Acetone
    • Ethyl acetate
  • pH Dependence: Solubility can also vary with pH, especially when ionizable groups are present. A basic environment can sometimes improve solubility due to ionization.

In summary, the solubility of 4-ethyl-2-(1-methyl-4-piperidyl)-5-phenyl-1H-pyrazol-3-one is multifaceted and requires careful consideration of solvent choice and environmental conditions. As a rule of thumb, organic solvents are preferable for dissolving this compound, while its behavior in aqueous solutions may be limited.

Interesting facts

Exploring 4-ethyl-2-(1-methyl-4-piperidyl)-5-phenyl-1H-pyrazol-3-one

4-ethyl-2-(1-methyl-4-piperidyl)-5-phenyl-1H-pyrazol-3-one is a fascinating compound with several intriguing applications and properties. Here are some interesting facts about this compound:

  • Pharmaceutical Relevance: The structure of this compound suggests potential pharmacological activities. Compounds with a pyrazol derivative are often explored for their anti-inflammatory and analgesic properties.
  • Chemical Versatility: The presence of the ethyl group and the piperidyl ring enhances the compound's reactivity, allowing for various chemical modifications that can lead to the synthesis of new derivatives with unique properties.
  • Research Interest: Due to its complex structure, this compound has garnered interest in the field of medicinal chemistry. Ongoing research may uncover additional therapeutic potentials, highlighting its relevance in drug development.
  • Intermolecular Interactions: The functional groups in this compound provide opportunities for studying hydrogen bonding and other intermolecular interactions, which are crucial for understanding its behavior in different environments.
  • Synthetic Pathways: The synthesis of such pyrazol derivatives involves multistep reactions that challenge chemists and provide rich educational experiences for students learning organic synthesis techniques.

In summary, 4-ethyl-2-(1-methyl-4-piperidyl)-5-phenyl-1H-pyrazol-3-one is more than just a chemical formula; it represents a blend of complexity and utility that captivates scientists and highlights the intricate nature of organic compounds.

Synonyms
PIPERYLONE
2531-04-6
piperylon
Piperylone [INN]
Piperilona
PR66
4-ethyl-2-(1-methylpiperidin-4-yl)-5-phenyl-1H-pyrazol-3-one
XWH5VH1L2F
PR-66
Piperylonum
PIPERYLONE [MI]
NoName_1468
UNII-XWH5VH1L2F
Piperylonum [INN-Latin]
Piperilona [INN-Spanish]
PIPERYLONE [MART.]
PIPERYLONE [WHO-DD]
SCHEMBL25509
CHEMBL2104576
DTXSID10902243
DTXSID90179956
PR 66
EINECS 219-788-4
HY-U00195
AKOS040735324
CS-7293
NS00003430
Q25100750
4-Ethyl-1-(1-methyl-4-piperidyl)-3-phenyl-3-pyrazolin-5-one
4-ETHYL-1-(1-METHYL-4-PIPERIDYL)-3-PHENYL-3-PYRAZOLAN-5-ONE