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Sulfamethoxazole

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Identification
Molecular formula
C10H11N3O3S3
CAS number
723-46-6
IUPAC name
4-(ethylamino)-2-(2-methoxyethyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide
State
State

At room temperature, sulfamethoxazole is in a solid state. It is usually found as a powder.

Melting point (Celsius)
169.00
Melting point (Kelvin)
442.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
253.28g/mol
Molar mass
253.2800g/mol
Density
1.6200g/cm3
Appearence

Sulfamethoxazole typically appears as a white or off-white crystalline powder. It is relatively odorless and has a slightly bitter taste.

Comment on solubility

Solubility of 4-(ethylamino)-2-(2-methoxyethyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide

The solubility of the compound 4-(ethylamino)-2-(2-methoxyethyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide (C10H11N3O3S3) is of significant interest, especially in pharmacological applications. Its solubility characteristics can be summarized as follows:

  • Polar vs. Nonpolar: The presence of polar functional groups such as sulfonamide and methoxy can enhance the solubility in polar solvents, like water.
  • Impact of pH: The solubility may vary with pH changes, as the ionization of the sulfonamide group could increase solubility in more acidic or basic environments.
  • Solvent Variability: This compound may exhibit differing solubilities in various organic solvents, indicating that a range of solvents may be tested to establish optimal conditions for dissolution.
  • Chemical Structure: The thieno[3,2-e]thiazine core is known for complex interactions with solvents, which can play a role in its overall solubility profile.

As a note, it is important to consider that the actual solubility can only be accurately determined through experimental solubility tests under controlled conditions. Understanding these factors not only aids in predicting solubility but also helps in designing formulations that enhance bioavailability and therapeutic efficacy.

Interesting facts

Interesting Facts about 4-(ethylamino)-2-(2-methoxyethyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide

This intriguing compound, often referred to in research circles as a thieno[3,2-e]thiazine derivative, possesses multiple features that make it a notable subject of study in the field of medicinal chemistry.

Structural Features

  • Thiazine Ring: The presence of a thiazine ring provides unique electronic properties that can influence biological activity.
  • Sulfonamide Group: The sulfonamide moiety is known for its antibacterial properties, making this compound a point of interest for the development of new antimicrobial agents.
  • Ethylamino Substituent: The ethylamino group can enhance solubility and alter bioavailability, which is crucial in drug design.
  • 2-Methoxyethyl Chain: This substituent may assist in improving the pharmacokinetic profile of the compound, potentially optimizing its absorption and distribution in biological systems.

Applications and Research

Research on compounds like this one has led to considerable advancements in the following areas:

  • Antibacterial Agents: With its sulfonamide functional group, this compound could serve as a scaffold for developing new antibiotics.
  • Antitumor Activity: Some thieno[3,2-e]thiazine derivatives have shown promise in anti-cancer studies, making this compound a potential candidate for oncological research.
  • Analytical Chemistry: Its unique structure can be used as a reference compound in spectroscopic analyses.

Noteworthy Insights

Understanding the biological mechanisms and interactions of such compounds can lead to breakthroughs in medicine. As one researcher noted, “The diversity of chemical scaffolds like thieno[3,2-e]thiazine derivatives opens new avenues for drug discovery.” By continuing to explore these compounds, scientists hope to generate innovative therapies that address unmet medical needs.

With ongoing advancements in synthetic techniques and pharmacological studies, it will be interesting to see how compounds such as 4-(ethylamino)-2-(2-methoxyethyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide shape the future of medicinal chemistry.

Synonyms
SCHEMBL7505749