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4-Fluoro-N'-isopropylbenzohydrazide

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Identification
Molecular formula
C10H13FN2O
CAS number
32902-03-3
IUPAC name
4-fluoro-N'-isopropyl-benzohydrazide
State
State
At room temperature, 4-fluoro-N'-isopropylbenzohydrazide is typically a solid.
Melting point (Celsius)
110.00
Melting point (Kelvin)
383.15
Boiling point (Celsius)
355.00
Boiling point (Kelvin)
628.15
General information
Molecular weight
182.22g/mol
Molar mass
182.2030g/mol
Density
1.1875g/cm3
Appearence

The compound typically appears as a white to off-white crystalline solid. It may also appear as a powder depending on its form and method of preparation.

Comment on solubility

Solubility of 4-fluoro-N'-isopropyl-benzohydrazide

The solubility of 4-fluoro-N'-isopropyl-benzohydrazide can be an intriguing aspect to explore, particularly due to its unique structural features.

This compound presents interesting solubility characteristics that can be summarized as follows:

  • Polarity: The presence of the -NH and -F substituents can contribute to varying levels of polarity, which may facilitate solubility in polar solvents.
  • Solvent Compatibility: It is generally more soluble in organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO), rather than in water, due to its hydrophobic hydrocarbon backbone.
  • Temperature Influence: The solubility may also increase with temperature—meaning that heating the solvent could enhance the dissolution process.
  • pH Sensitivity: The solubility can be influenced by the pH of the environment, as ionic interactions can change under different pH conditions.

It is important to consider that solubility data can vary based on factors such as purity and specific experimental conditions. Therefore, when working with 4-fluoro-N'-isopropyl-benzohydrazide, one should consult empirical data or conduct solubility tests to determine practical limits.

In summary, the solubility of this compound can be influenced by a range of factors and is an essential consideration in applications where it may be utilized. Understanding the nuances of its solubility can significantly impact its handling and use in various chemical processes.

Interesting facts

Interesting Facts about 4-Fluoro-N'-isopropyl-benzohydrazide

4-Fluoro-N'-isopropyl-benzohydrazide is an intriguing compound that belongs to the hydrazide family, and it presents a variety of fascinating characteristics:

  • Biological Activity: This compound has garnered attention for its potential biological activities. Studies indicate that hydrazides often exhibit anti-inflammatory and antimicrobial properties, making them of interest in pharmaceutical research.
  • Versatile Synthesis: The chemical structure of 4-fluoro-N'-isopropyl-benzohydrazide allows for various synthetic pathways. This versatility enhances its usability in diverse chemical and biological applications.
  • Substituent Influence: The presence of the fluorine atom in this hydrazide is noteworthy as it can significantly influence the compound's reactivity and stability. Fluorine is known for its electronegativity, and its incorporation into organic compounds can modify physical and chemical properties.
  • Structure-Activity Relationship (SAR): Researchers often study this compound in a SAR context, analyzing how changes in molecular structure affect biological activity. This helps in drug design and development for optimizing therapeutic agents.
  • Application in Organic Synthesis: Beyond its biological implications, 4-fluoro-N'-isopropyl-benzohydrazide serves as a useful intermediate in organic synthesis, potentially leading to the creation of more complex molecules.

As the exploration into hydrazide derivatives continues, compounds like 4-fluoro-N'-isopropyl-benzohydrazide provide essential insights into the realms of medicinal chemistry and organic synthesis, prompting further research and discovery.

Synonyms
p-Fluorobenzoic acid 2-isopropylhydrazide
BENZOIC ACID, p-FLUORO-, 2-ISOPROPYLHYDRAZIDE
2925-02-2
JDV28SR3F2
NSC-522547
DTXSID10183510
DTXCID50106001
NSC 522547
BRN 2578627
UNII-JDV28SR3F2
P 1167
SCHEMBL15486710
LHTLVTJXNDIKTE-UHFFFAOYSA-N
4-fluoro-N'-isopropylbenzohydrazide
NSC522547
4-fluoro-N-propan-2-yl-benzohydrazide
DS-005340