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4-Fluoroaniline

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Identification
Molecular formula
C6H6FN
CAS number
371-40-4
IUPAC name
4-fluoroaniline
State
State

4-Fluoroaniline is typically a liquid but can also exist as a solid, particularly below its melting point of 12°C.

Melting point (Celsius)
12.00
Melting point (Kelvin)
285.15
Boiling point (Celsius)
184.00
Boiling point (Kelvin)
457.15
General information
Molecular weight
111.12g/mol
Molar mass
111.1150g/mol
Density
1.1630g/cm3
Appearence

4-Fluoroaniline appears as a clear to pale yellow liquid or solid. It is commonly found as a liquid at temperatures slightly above room temperature.

Comment on solubility

Solubility of 4-fluoroaniline

4-fluoroaniline, with the chemical formula C6H6FN, presents intriguing characteristics regarding its solubility in various solvents. Understanding its solubility is crucial for applications in synthesis and material science.

Key Points on Solubility:

  • 4-fluoroaniline is generally soluble in organic solvents such as ethanol and methanol.
  • While it shows moderate solubility in water, this is influenced by the presence of the amino group which can form hydrogen bonds with water molecules.
  • The fluoro group can affect its solubility due to its electronegativity, which can alter the polarity of the compound.
  • Typical solubility might be described as being better in polar solvents compared to non-polar ones.

In practical terms, "solubility behavior can be complex," often necessitating empirical testing to ascertain precise solubility limits in various solvents. This characteristic makes 4-fluoroaniline a valuable compound in organic chemistry and industrial applications, where understanding its solubility can dictate its functionality in reactions.

Interesting facts

Interesting Facts about 4-Fluoroaniline

4-Fluoroaniline is a fascinating organic compound with unique properties and applications in various fields of science and industry. This aromatic amine is derived from aniline, where a fluorine atom is substituted at the para position of the phenyl ring. Here are some engaging points to consider:

  • Chemical Reactivity: Due to the electronegative fluorine atom, 4-fluoroaniline exhibits interesting reactivity patterns compared to its non-fluorinated counterparts. This can make it a valuable intermediate in the synthesis of pharmaceuticals and agrochemicals.
  • Role in Drug Synthesis: The presence of the fluorine atom enhances certain biological activities, making 4-fluoroaniline a key building block in the development of various drug candidates. It is often involved in the synthesis of anti-cancer and anti-inflammatory medications.
  • Research and Development: Scientists study 4-fluoroaniline to better understand the effects of fluorination on molecular behavior. Fluorine substituents can influence solubility, stability, and even biological activity, thereby opening up avenues for novel compound discovery.

As a student of chemistry, you might also find it intriguing to explore the different **methods of synthesis** for this compound, including nucleophilic substitution reactions and other advanced organic synthesis techniques. The compound serves as a reminder of how small changes in molecular structure can lead to significant differences in properties and applications.

"The devil is in the details," as they say, and in the case of 4-fluoroaniline, a mere fluorine substitution is proof that even **minor modifications can lead to monumental discoveries** in the chemical world.

Synonyms
4-FLUOROANILINE
371-40-4
p-Fluoroaniline
1-Amino-4-fluorobenzene
4-Fluorobenzenamine
Benzenamine, 4-fluoro-
p-Fluorophenylamine
Aniline, p-fluoro-
4-Fluoronaniline
Aniline, 4-fluoro-
para-Fluoroaniline
4-Fluoro-phenylamine
4-Fluoranilin
4-fluorophenylamine
4-Fluoranilin [Czech]
Fluoroaniline, p-
p-aminofluorobenzene
NSC 579
MFCD00007829
CCRIS 5059
DTXSID9022027
CHEBI:28546
4-fluoraniline
HSDB 2691
EINECS 206-735-5
UNII-60HI1G076Z
4-fluorobenzenaminium
BRN 0742030
AI3-52386
NSC-579
60HI1G076Z
(4-fluorophenyl)-amine
4-FLUOROANILINE [MI]
CHEMBL32014
DTXCID602027
4-FLUOROANILINE [HSDB]
EC 206-735-5
4-12-00-01104 (Beilstein Handbook Reference)
UN 2944
fluoranilin
Fluoroanilines
pFluoroaniline
4flouroaniline
p-fluoraniline
4Fluoronaniline
4-flouroaniline
4-fluoroanaline
4Fluoranilin
4-floroaniline
4-fluoroanilin
4-fluroaniline
paraFluoroaniline
p-fluoro-aniline
picolinafen TP2
Aniline, pfluoro
pFluorophenylamine
4 -fluoroaniline
4- fluoroaniline
4-fluoro aniline
4-fluoro-aniline
4Fluorobenzenamine
4-fluoranylaniline
Aniline, 4fluoro
4-fluorobenzeneamine
1Amino4fluorobenzene
Fluoranilin (Czech)
Benzenamine, 4fluoro
(4-fluorophenyl)amine
1,4-fluorobenzenamine
4-Fluoro-1-benzenamine
4-fluoro-1-aminobenzene
4-Fluoroaniline, 99%
WLN: ZR DF
Aniline, p-fluoro-(8CI)
SCHEMBL3199
NSC579
BCP21217
Tox21_202828
BDBM50282614
STL168895
AKOS000119114
FF23415
PS-9263
NCGC00260374-01
CAS-371-40-4
PD055449
DB-023950
F0033
NS00010860
4-Fluoroaniline, technical, >=97.0% (GC)
EN300-18060
D78529
A823539
p-Fluoroaniline [UN2941] [Keep away from food]
Q27103764
Z57127563
F2190-0427
1-Amino-4-fluorobenzene;4-Fluorobenzenamine;4-Fluorophenylamine
206-735-5