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4-Fluorobenzenesulfonyl chloride

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Identification
Molecular formula
C6H4ClFO2S
CAS number
1006-32-2
IUPAC name
4-fluorobenzenesulfonyl chloride
State
State

At room temperature, 4-Fluorobenzenesulfonyl chloride can exist as either a liquid or a solid, depending on its exact temperature and environmental conditions. It crystallizes easily which is why it may sometimes be observed in solid form.

Melting point (Celsius)
39.00
Melting point (Kelvin)
312.15
Boiling point (Celsius)
234.00
Boiling point (Kelvin)
507.15
General information
Molecular weight
192.61g/mol
Molar mass
192.6110g/mol
Density
1.4545g/cm3
Appearence

4-Fluorobenzenesulfonyl chloride appears as a clear, colorless to light yellow liquid. It may also sometimes be observed as a solid due to crystallization. The compound has a pungent and characteristic odor typically associated with sulfonyl chlorides.

Comment on solubility

Solubility of 4-Fluorobenzenesulfonyl Chloride

4-Fluorobenzenesulfonyl chloride (C6H4ClFNO2S) displays interesting solubility characteristics primarily due to its sulfonyl chloride functional group. This compound is known to be:

  • Soluble in organic solvents: 4-Fluorobenzenesulfonyl chloride shows excellent solubility in various organic solvents, such as:
    • Dichloromethane
    • Ethyl acetate
    • Acetone
  • Limited solubility in water: The presence of the sulfonyl chloride group allows for some interaction with water; however, its overall solubility is relatively low due to:
    • Hydrophobic aromatic characteristics
    • The bulky nature of the molecule

In summary, while 4-fluorobenzenesulfonyl chloride is quite soluble in many organic solvents, its low water solubility influences its applications and handling in various chemical processes. As a general rule, compounds with significant aromatic character tend to favor organic over aqueous solubility, and this compound is no exception.

Interesting facts

Interesting Facts About 4-Fluorobenzenesulfonyl Chloride

4-Fluorobenzenesulfonyl chloride, often abbreviated as 4-FBSCl, is a fascinating compound in the realm of organic chemistry. Its unique structure and reactivity make it an important reagent in various synthetic processes. Here are some captivating details about this compound:

  • Reactivity: 4-Fluorobenzenesulfonyl chloride is recognized for its ability to act as an electrophilic agent, which can be useful in the synthesis of sulfonamide compounds. This property facilitates multiple reactions, especially in pharmaceutical chemistry.
  • Synthetic Applications: This compound serves as a versatile intermediate in organic synthesis, commonly used in the preparation of sulfonyl derivatives. It is particularly valued in the synthesis of complex organic molecules, including those used in drug discovery and development.
  • Selectivity: Due to the presence of the fluorine atom, the compound exhibits high selectivity in electrophilic aromatic substitution reactions. This attribute enables chemists to tailor reactions towards desired products with greater precision.
  • History: Studies involving 4-fluorobenzenesulfonyl chloride have contributed significantly to the advancement of synthetic methodologies in organic chemistry. The compound's utility in making various sulfonyl-containing compounds has been a focal point in research and industrial applications.
  • Safety Concerns: As with many sulfonyl chlorides, proper handling of 4-fluorobenzenesulfonyl chloride is essential. It can be hazardous, requiring strict safety protocols to mitigate the risks of exposure.

In summary, 4-fluorobenzenesulfonyl chloride exemplifies the intricate relationship between molecular structure and chemical behavior, enhancing our ability to design and create new compounds in a variety of applications. Its role in modern chemistry cannot be overstated.

Synonyms
4-Fluorobenzenesulfonyl chloride
349-88-2
4-Fluorobenzene-1-Sulfonyl Chloride
4-Fluorobenzenesulphonyl chloride
p-Fluorobenzenesulfonyl chloride
Benzenesulfonyl chloride, 4-fluoro-
4-Fluorophenylsulfonyl chloride
Benzenesulfonyl chloride, p-fluoro-
4-fluorobenzenesulfonylchloride
4-fluorobenzenesulfonic acid chloride
4-fluoro-benzenesulfonyl chloride
MFCD00007438
4-fluorobenzensulfonyl chloride
EINECS 206-493-0
NSC 140128
P-FLUOROBENZENESULPHONYL CHLORIDE
2M9GLL38TN
4-fluorophenylsulphonyl chloride
DTXSID3059846
BFXHJFKKRGVUMU-UHFFFAOYSA-
NSC-140128
p-FC6H4SO2Cl
UNII-2M9GLL38TN
SCHEMBL17242
4-fluorophenylsulfonylchloride
4fluorophenylsulfonyl chloride
4fluorobenzenesulfonyl chloride
p-fluorophenylsulfonyl chloride
pFluorobenzenesulfonyl chloride
4-fluorobezenesulfonyl chloride
4-flurobenzenesulfonyl chloride
p-fluorobenzenesulphonylchloride
p-flourobenzenesulfonyl chloride
4-fluoro benzenesulfonylchloride
4-fluoro-benzenesulfonylchloride
4-fluorobenzene sulfonylchloride
4-Fluorobenzenesulphonylchloride
4-Fluoro-benzensulfonyl chloride
4-fluorobenzene sulphonylchloride
4-fluorophenyl sulfonyl chloride
DTXCID9038925
p-fluoro benzenesulfonyl chloride
4-fluoro benzenesulfonyl chloride
4-fluorobenzene sulfonyl chloride
4-fluorobenzene-sulfonyl chloride
Benzenesulfonyl chloride, pfluoro
(4-fluorophenyl)sulfonyl chloride
4-fluoro-phenyl sulfonyl chloride
Benzenesulfonyl chloride, 4fluoro
p-fluorobenzene sulphonyl chloride
4-fluoro-benzenesulphonyl chloride
4-fluorobenzene sulphonyl chloride
4-fluorobenzene-sulphonyl chloride
4-Fluoro benzene sulfonyl chloride
4-fluoro-benzene sulfonyl chloride
4-fluoro-benzene-sulfonyl chloride
4-fluorobenzene-1-sulfonylchloride
BCP15286
Benzenesulphonyl chloride, p-fluoro-
Benzenesulphonyl chloride, 4-fluoro-
NSC140128
STL163968
4-fluoro-benzene-1-sulfonyl chloride
4-fluorobenzenesulphonic acid chloride
AKOS000120306
4-Fluorobenzenesulfonyl chloride, 98%
CS-W008916
FF00435
GS-3219
BP-20273
DB-048708
F0202
NS00041646
EN300-17447
P20473
doi:10.14272/BFXHJFKKRGVUMU-UHFFFAOYSA-N.1
Z56940934
F0808-2036