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4-Fluorobenzohydrazide

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Identification
Molecular formula
C7H7FN2O
CAS number
455-87-8
IUPAC name
4-fluorobenzohydrazide
State
State

At room temperature, 4-Fluorobenzohydrazide is in a solid state.

Melting point (Celsius)
148.00
Melting point (Kelvin)
421.15
Boiling point (Celsius)
320.00
Boiling point (Kelvin)
593.15
General information
Molecular weight
154.16g/mol
Molar mass
154.1550g/mol
Density
1.3760g/cm3
Appearence

4-Fluorobenzohydrazide is a white to off-white solid. It may appear as a crystalline powder. This is typical of many small aromatic organic compounds, especially those that are fluorinated.

Comment on solubility

Solubility of 4-fluorobenzohydrazide

4-fluorobenzohydrazide, with the chemical formula C7H8FN3O, exhibits noteworthy solubility characteristics that can influence its applications in various fields. Understanding these properties is essential for laboratory work and chemical synthesis.

General Solubility Properties

  • Solvent Compatibility: 4-fluorobenzohydrazide is primarily soluble in polar solvents. This includes solvents such as:
    • Water
    • Methanol
    • Ethanol
    • DMSO (Dimethyl sulfoxide)
  • Thermal Influence: The solubility may increase with temperature, indicating that higher temperatures can enhance the dissolution rate of this compound.
  • pH Dependency: Its solubility might also depend on the pH of the solution, as compounds with amine and hydrazide functionality often exhibit varying solubility in acidic or basic conditions.

In practice, researchers should consider these factors when preparing solutions involving 4-fluorobenzohydrazide to ensure optimal usage and reactivity. Remember, the interaction with specific solvents is critical in determining the efficacy and outcome of chemical reactions.

Overall, while 4-fluorobenzohydrazide is soluble in several common solvents, tailored approaches towards solvent selection are advised to achieve desired concentrations for specific applications.

Interesting facts

Interesting Facts About 4-Fluorobenzohydrazide

4-Fluorobenzohydrazide is an intriguing compound that has gained attention in various fields of chemistry, particularly in synthetic organic chemistry and medicinal chemistry. Here are some fascinating aspects worth noting:

  • Structure and Properties: This compound features a benzene ring with a fluorine atom and hydrazide functional group, providing unique properties that can influence its reactivity and biological activity.
  • Reactivity: Due to the presence of the hydrazide moiety, 4-fluorobenzohydrazide can act as an important building block in the synthesis of various pharmaceutical compounds, including potential anti-cancer agents.
  • Role in Research: The compound is often utilized in drug development research for its ability to form hydrazones, an essential reaction in the formation of pharmaceutical intermediates.
  • Analytical Techniques: 4-Fluorobenzohydrazide can be effectively analyzed using techniques such as NMR spectroscopy, IR spectroscopy, and mass spectrometry. These methods help to confirm its structure and purity.

Applications in Medicinal Chemistry

Several studies have investigated the potential application of 4-fluorobenzohydrazide in medicinal chemistry:

  • Its derivatives are being explored for their anti-inflammatory and anti-tumor properties.
  • Research shows that modifications of its structure can enhance the pharmacological profile of related compounds.

As the field of organic synthesis advances, compounds like 4-fluorobenzohydrazide continue to serve as vital tools for creating novel chemical entities, showcasing the ever-evolving relationship between chemical structures and their biological activities.

Synonyms
4-Fluorobenzhydrazide
4-Fluorobenzohydrazide
456-06-4
4-Fluorobenzoic hydrazide
p-Fluorobenzoic acid hydrazide
4-fluorobenzoic acid hydrazide
p-Fluorobenzoylhydrazine
4-fluorobenzenecarbohydrazide
Benzoic acid, 4-fluoro-, hydrazide
Hydrazine, (p-fluorobenzoyl)-
4-Fluorobenzoylhydrazine
BENZOIC ACID, p-FLUORO-, HYDRAZIDE
MFCD00060562
4-fluoro benzoyl hydrazine
4-Fluorobenzhydrazide,
BRN 1946324
4-fluoro-benzoic acid hydrazide
4-fluoro-benzhydrazide
4-fluoro-benzohydrazide
4-Fluorobenzohydrazide #
4-09-00-00955 (Beilstein Handbook Reference)
SCHEMBL222973
4-Fluorobenzoic hydrazide, 96%
DTXSID30196561
JS-044C
STK074196
AKOS000116244
CS-W022181
FF53948
SB85944
SY007335
UPCMLD0ENAT0511-4819:001
DB-051322
F0540
NS00125680
EN300-03624
Z56862389
F3374-0929
4-Fluorobenzoic acid hydrazide, 4-Fluorobenzohydrazide, 4-Fluorobenzenecarbohydrazide
610-264-4