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4-Fluorobenzoic acid

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Identification
Molecular formula
C7H5FO2
CAS number
456-22-4
IUPAC name
4-fluorobenzoic acid
State
State
The compound is in a solid state at room temperature, characterized by its crystalline structure.
Melting point (Celsius)
185.00
Melting point (Kelvin)
458.15
Boiling point (Celsius)
250.00
Boiling point (Kelvin)
523.15
General information
Molecular weight
140.11g/mol
Molar mass
140.1100g/mol
Density
1.5130g/cm3
Appearence

4-Fluorobenzoic acid appears as a white crystalline solid. It is relatively well-defined and distinct in its solid state, with no notable coloration or transparency, remaining a fine powder or crystalline pieces.

Comment on solubility

Solubility of 4-fluorobenzoic acid

4-fluorobenzoic acid, with the chemical formula C7H5FCOOH, exhibits a range of solubility characteristics that are important to understand for various applications. The compound is known to be quite soluble in polar solvents, particularly in water, due to the capability of its carboxylic acid functional group to engage in hydrogen bonding.

Key points regarding its solubility include:

  • Water Solubility: 4-fluorobenzoic acid is generally soluble in water, with solubility increasing with temperature.
  • Organic Solvents: This compound is also soluble in a variety of organic solvents, such as ethanol and acetone, making it versatile for many synthetic processes.
  • Effect of pH: The solubility can be affected by pH, as the carboxyl group can donate a proton, yielding an anionic form that is more soluble in basic conditions.

In conclusion, while the overall solubility of 4-fluorobenzoic acid in different solvents can vary, its ability to form interactions with both polar and nonpolar substrates positions it as an interesting compound for exploration in both pharmaceutical and industrial chemistry. It serves as an excellent example of how molecular structure can dictate solubility behavior.

Interesting facts

Interesting Facts about 4-Fluorobenzoic Acid

4-Fluorobenzoic acid, a derivative of benzoic acid, is a fascinating compound with intriguing properties and applications. Here are some noteworthy facts:

  • Structural Significance: The compound features a fluorine atom attached to the para position of the carboxylic acid group in the benzoic acid structure. This substitution significantly alters its reactivity and interaction with other molecules.
  • Polar Interactions: The presence of the electronegative fluorine atom enhances the polarity of the compound, potentially affecting its solubility and interactions in various chemical environments.
  • Synthesis: 4-Fluorobenzoic acid can be synthesized through various methods, including the fluorination of benzoic acid or using more advanced synthetic routes that ensure regioselectivity in the substitution process.
  • Pharmaceutical Applications: This compound is often utilized in the development of pharmaceuticals and agrochemicals. Its structure can contribute to the molecular properties needed for effective drug design and activity.
  • Research Interest: Scientists are continually exploring the potential applications of 4-fluorobenzoic acid in organic synthesis and materials science due to its unique chemical characteristics.

As the famous chemist Marie Curie said, "Nothing in life is to be feared, it is only to be understood." Understanding the nuances of compounds like 4-fluorobenzoic acid can lead to remarkable discoveries and advancements in various fields.

Overall, 4-fluorobenzoic acid remains an exciting subject of study for chemists and researchers interested in the intersection of organic chemistry and practical application.

Synonyms
4-FLUOROBENZOIC ACID
456-22-4
p-Fluorobenzoic acid
Benzoic acid, 4-fluoro-
para-Fluorobenzoic acid
Benzoic acid, p-fluoro-
4-fluoro-benzoic acid
4-fluoro benzoic acid
MFCD00002530
V5ROO2HOU4
p-flurobenzoic acid
CHEBI:20364
EINECS 207-259-0
NSC 10321
NSC-10321
FLUOROBENZOIC ACID, P-
DTXSID9060023
4-FLUOROBENZOIC ACID [MI]
4-flurobenzoic acid
NSC 10321; p-Fluorobenzoic Acid;
4-Fluorobenzoicacid
p-fluoro-Benzoic acid
UNII-V5ROO2HOU4
4fluorobenzoic acid
1Y6
Benzoic acid, pfluoro
4-flouro benzoic acid
Benzoic acid, 4fluoro
bmse000739
SCHEMBL27498
4-Fluorobenzoic acid, 98%
Benzoic acid, pfluoro (8CI)
CHEMBL316860
Benzoic acid, p-fluoro-(8CI)
DTXCID3040435
NSC10321
STL141031
AKOS000118941
CS-W014393
HY-W013677
PS-9056
AC-10259
SY001592
DB-024083
4-Fluorobenzoic acid,purified by sublimation
F0112
NS00080419
EN300-18213
C02371
D70922
AE-562/40177766
4-Fluorobenzoic acid, 99%, purified by sublimation
Q63390495
Z57367354
F2191-0062
207-259-0
695-034-1