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4-fluorobenzonitrile

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Identification
Molecular formula
C7H4FN
CAS number
1194-02-1
IUPAC name
4-fluorobenzonitrile
State
State
At room temperature, 4-fluorobenzonitrile is in a solid state, typically as a white crystalline powder.
Melting point (Celsius)
46.00
Melting point (Kelvin)
319.15
Boiling point (Celsius)
194.00
Boiling point (Kelvin)
467.15
General information
Molecular weight
121.11g/mol
Molar mass
121.1120g/mol
Density
1.1420g/cm3
Appearence

4-Fluorobenzonitrile appears as a white crystalline solid. It may appear slightly off-white when impurities are present. Its crystalline form reflects light, giving it a glossy appearance.

Comment on solubility

Solubility of 4-Fluorobenzonitrile

4-Fluorobenzonitrile, with the chemical formula C7H4FN, exhibits interesting solubility properties that are worth noting for various applications.

Solubility Characteristics

When considering the solubility of 4-fluorobenzonitrile:

  • Polar Solvents: This compound is generally more soluble in polar organic solvents such as methanol and ethanol due to its polar nitrile group.
  • Non-Polar Solvents: It exhibits significant solubility in non-polar aprotic solvents, such as hexane and toluene, owing to its aromatic structure.
  • Water Solubility: 4-Fluorobenzonitrile has limited solubility in water, a common trait among aromatic nitriles, which makes it less favorable for applications requiring aqueous solutions.

Factors Influencing Solubility

Several factors can influence the solubility of 4-fluorobenzonitrile:

  • Temperature: Increasing temperature generally enhances solubility, allowing for greater dissolution in organic solvents.
  • Substituent Effects: The presence of the fluorine atom can affect intermolecular interactions, which can either hinder or promote solubility depending on the solvent.
  • pH Considerations: While 4-fluorobenzonitrile itself is not acidic or basic, the pH of the solvent may influence the stability and solubility of any interacting species.

In summary, 4-fluorobenzonitrile displays versatile solubility properties across different solvent types, making it applicable in various chemical processes and reactions. Its solubility profile is characterized by a balance between polar and non-polar solubility behaviors, which are essential for its potential uses in organic synthesis.

Interesting facts

Interesting Facts about 4-Fluorobenzonitrile

4-Fluorobenzonitrile is a fascinating compound that has garnered interest in both academic research and industrial applications. Here are some key highlights:

  • Structural Characteristics: This compound is characterized by a benzene ring with a fluorine atom and a nitrile group, –C≡N, attached to the para position. This unique structure contributes to its reactivity and properties.
  • Reactivity: The presence of the fluorine atom makes 4-fluorobenzonitrile a highly reactive intermediate in organic synthesis. It serves as a valuable building block for a variety of chemical reactions, including nucleophilic substitutions and carbon-carbon bond formations.
  • Applications in Pharmaceuticals: Researchers utilize 4-fluorobenzonitrile in the synthesis of various pharmaceutical agents. Its ability to introduce a fluorine atom, which can enhance the bioactivity of drug candidates, is particularly noteworthy.
  • Role in Material Science: This compound also finds application in the development of functional materials. Its properties make it suitable for creating polymer materials that exhibit unique electrical and thermal characteristics.
  • Research Opportunities: The study of 4-fluorobenzonitrile presents numerous avenues for exploration. Its interaction with different nucleophiles and electrophiles can yield a vast array of derivatives, contributing to ongoing research in organic and medicinal chemistry.

In summary, 4-fluorobenzonitrile is not only a compound of significant interest in chemical synthesis but also plays a crucial role in the development of new materials and pharmaceuticals. Its distinct properties open up many possibilities, highlighting the importance of functional groups in organic chemistry. As scientists delve deeper into its applications, we can anticipate exciting advancements that stem from this versatile compound.

Synonyms
4-Fluorobenzonitrile
Benzonitrile, 4-fluoro-
4-CYANOFLUOROBENZENE
4-fluorocyanobenzene
EINECS 214-784-9
4VJG35CQV3
NSC 88330
NSC-88330
DTXSID6061600
4-FLUORO-BENZOIC ACID-NITRILE
DTXCID4033502
214-784-9
aekvbbngwbbyll-uhfffaoysa-n
inchi=1/c7h4fn/c8-7-3-1-6(5-9)2-4-7/h1-4
1194-02-1
p-Fluorobenzonitrile
p-Cyanofluorobenzene
BENZONITRILE, p-FLUORO-
143234-87-1
4-fluoro-benzonitrile
MFCD00001812
4-fluorobenzenecarbonitrile
4-FLUOROBENZONITRIL
4fluorobenzonitrile
4-fluorobenznitrile
4-luorobenzonitrile
4-Fluorobenzonitile
NSC88330
4-cyano fluorobenzene
4-fluoro benzonitrile
4-fluorobenzo-nitrile
para-fluorobenzonitrile
1-fluoro-4-cyanobenzene
4-monofluorobenzene nitrile
UNII-4VJG35CQV3
4-Fluorobenzonitrile, 99%
NCIOpen2_001282
SCHEMBL39936
CHEMBL3248213
CHEBI:194793
CS-D1694
STK802611
AKOS000121499
PS-9223
DB-000373
F0221
NS00042386
EN300-16533
F0001-0320