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4-Fluorobutyric acid

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Identification
Molecular formula
C4H7FO2
CAS number
372-94-5
IUPAC name
4-fluorobutanoic acid
State
State

4-Fluorobutyric acid is a liquid at room temperature.

Melting point (Celsius)
-42.00
Melting point (Kelvin)
231.15
Boiling point (Celsius)
206.00
Boiling point (Kelvin)
479.15
General information
Molecular weight
106.09g/mol
Molar mass
106.0930g/mol
Density
1.1430g/cm3
Appearence

4-Fluorobutyric acid typically appears as a colorless to light yellow liquid. It is often characterized by a pungent and sharp odor.

Comment on solubility

Solubility of 4-Fluorobutanoic Acid

4-Fluorobutanoic acid, with the chemical formula C4H7F O2, exhibits notable solubility properties that are of interest in various chemical contexts:

  • Water Solubility: This compound possesses good solubility in water due to its carboxylic acid functional group, which can form hydrogen bonds with water molecules. This property is essential for its biological and chemical applications.
  • Solvents: In addition to water, 4-fluorobutanoic acid is soluble in various organic solvents such as ethanol and acetone, making it versatile in different chemical reactions.
  • Temperature Dependence: Solubility can vary with temperature; generally, an increase in temperature will enhance the solubility of 4-fluorobutanoic acid in both water and organic solvents.

As a result, 4-fluorobutanoic acid is classified as a polar compound, where the presence of the electronegative fluorine atom contributes to its overall solubility characteristics. Understanding the solubility of this compound can significantly impact its usage in synthesis and industrial applications.

Interesting facts

Interesting Facts about 4-Fluorobutanoic Acid

4-Fluorobutanoic acid is a fascinating compound in the realm of organic chemistry, with its unique structure and properties leading to various applications in scientific research.

Key Characteristics

  • Functional Group: This compound is classified as a carboxylic acid due to the presence of the -COOH group, which is pivotal in its reactivity and bonding characteristics.
  • Fluorine Substitution: The fluorine atom attached to the fourth carbon of the butanoic acid chain introduces both polar and electronic effects, which can significantly influence its chemical behavior.

Applications

  • Pharmaceutical Development: 4-Fluorobutanoic acid is often explored in drug synthesis, particularly in the development of new therapeutic agents.
  • Biochemical Studies: Its unique properties make it useful in studying metabolic pathways and enzyme activity due to its ability to interact with biological systems.

Interesting Insights

One of the most intriguing aspects of 4-fluorobutanoic acid is its potential use as a bioisostere. By replacing hydrogen with fluorine, researchers can enhance the stability and bioavailability of compounds while maintaining similar biological activity. This capability is especially important in drug design, where even slight molecular modifications can lead to significant changes in efficacy.

Furthermore, the compound serves as a valuable reagent in synthetic organic chemistry, enabling the introduction of fluorine in various organic molecules. This transformation is a critical area of interest, as fluorinated compounds exhibit unique properties that can enhance their effectiveness in different applications.

In summary, 4-fluorobutanoic acid represents a compelling area of study in chemical science, exhibiting unique structural properties, diverse applications, and significant implications in both pharmaceutical innovation and organic synthesis.

Synonyms
4-fluorobutanoic Acid
462-23-7
DTXSID60274508
DTXCID10203489
832-795-2
4-FLUOROBUTYRIC ACID
MFCD17014695
4-fluorobutanoicAcid
4-fluoro-butyric acid
SCHEMBL1031829
AKOS006380509
FF77419
PS-18544
SY205598
E88366
EN300-243981