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4-Fluorophenol

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Identification
Molecular formula
C6H5FO
CAS number
371-41-5
IUPAC name
4-fluorophenol
State
State

At room temperature, 4-fluorophenol is typically found as a solid due to its relatively high melting point.

Melting point (Celsius)
38.00
Melting point (Kelvin)
311.15
Boiling point (Celsius)
185.00
Boiling point (Kelvin)
458.15
General information
Molecular weight
112.10g/mol
Molar mass
112.1020g/mol
Density
1.1920g/cm3
Appearence

4-Fluorophenol is a colorless solid that tends to appear as needle-like crystals. When pure, it is usually transparent and free of any noticeable color.

Comment on solubility

Solubility of 4-fluorophenol

4-fluorophenol, with the chemical formula C6H5FO, exhibits interesting solubility characteristics that can be attributed to its molecular structure and functional groups. Here are some key points regarding its solubility:

  • Polarity: The presence of both the hydroxyl (-OH) group and the fluorine atom contributes to the compound's overall polarity, enhancing its ability to interact with polar solvents.
  • Solvent Compatibility: 4-fluorophenol is generally soluble in organic solvents such as ethanol and acetone, making it a versatile compound for various chemical reactions.
  • Water Solubility: It has moderate solubility in water, primarily due to hydrogen bonding potential offered by the hydroxyl group.
  • Temperature Dependence: Solubility can vary significantly with temperature; typically, solubility increases as the temperature rises.
  • Impurities and pH Effects: The presence of impurities or changes in pH can affect solubility, particularly in aqueous solutions.

In summary, while 4-fluorophenol demonstrates significant solubility in various solvents, it is essential to consider temperature and solvent compatibility as critical factors in its behavior in solution.

Interesting facts

Interesting Facts About 4-Fluorophenol

4-Fluorophenol is a fascinating organic compound that belongs to the family of phenols. This compound features a hydroxyl group (–OH) attached to a benzene ring, with a fluorine atom positioned at the para position relative to the hydroxyl group. Here are some compelling insights:

  • Versatile Intermediate: 4-Fluorophenol serves as an important building block in the synthesis of various chemical compounds, including pharmaceuticals, agrochemicals, and specialty chemicals.
  • Biological Activity: Research has indicated that 4-fluorophenol exhibits antimicrobial properties, making it of interest for developing antibacterial agents.
  • Polar Character: The presence of the fluorine atom increases the polarity of the molecule, enhancing its reactivity and interactions with biological systems.
  • Environmental Impact: As a fluorinated compound, it's essential to study the environmental implications of 4-fluorophenol, especially considering the persistence of halogenated compounds in ecosystems.
  • Analytical Importance: 4-Fluorophenol is often used as a reference compound in analytical chemistry, including methods such as gas chromatography and mass spectrometry.

The compound not only poses intriguing chemical characteristics but also opens avenues for research and development in various fields. As one delves deeper, one might appreciate how seemingly simple compounds can lead to significant advancements in technology and health.

In the words of chemist Robert H. Grubbs, "In chemistry, there are no shortcuts; the true insights come from understanding each atom's behavior and interaction." This resonates well with the study of compounds like 4-fluorophenol.


Synonyms
4-FLUOROPHENOL
371-41-5
p-Fluorophenol
Phenol, 4-fluoro-
Phenol, p-fluoro-
CCRIS 665
MFCD00002316
4-Fluoro-phenol
EINECS 206-736-0
K6DT6TR5E5
NSC 10295
BRN 1362752
NSC-10295
FLUOROPHENOL, 4-
4-HYDROXYPHENYL FLUORIDE
DTXSID0052047
CHEBI:42533
EC 206-736-0
4-06-00-00773 (Beilstein Handbook Reference)
PARA-FLUOROPHENOL
FPN
4fluorophenol
p-fluoro phenol
p-fluoro-phenol
4-flourophenol
4fluoro phenol
4-flurophenol
Phenol, pfluoro
4-fluoro phenol
Phenol, 4fluoro
4-fluoranylphenol
Phenol, 4-fluoro-; Phenol, p-fluoro- (6CI,8CI); 4-Fluorophenol; 4-Hydroxyphenyl fluoride; NSC 10295; p-Fluorophenol
4-Fluorophenol, 99%
UNII-K6DT6TR5E5
SCHEMBL78213
DTXCID5030614
DTXSID00175727
NSC10295
STL183322
AKOS000119023
CCG-302492
CS-W008731
FF31943
PS-9253
DB-028894
F0160
NS00009958
EN300-19431
A823540
Q27460393
F0001-1065
206-736-0