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Methylphenidate hydrochloride

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Identification
Molecular formula
C14H19ClNO2
CAS number
298-59-9
IUPAC name
(4-hydroxy-1-methyl-4-phenyl-3-piperidyl)-phenyl-methanone;hydrochloride
State
State

At room temperature, methylphenidate hydrochloride is a solid. It is stable under standard conditions and holds its form as a crystalline powder.

Melting point (Celsius)
224.50
Melting point (Kelvin)
497.60
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
299.80g/mol
Molar mass
299.8010g/mol
Density
1.3540g/cm3
Appearence

Methylphenidate hydrochloride appears as a white to off-white crystalline powder. It is odorless and its appearance makes it easy to handle in laboratory settings. When formulated for pharmaceutical use, it is typically compressed into tablets or mixed as a solution.

Comment on solubility

Solubility of (4-hydroxy-1-methyl-4-phenyl-3-piperidyl)-phenyl-methanone hydrochloride

The solubility of (4-hydroxy-1-methyl-4-phenyl-3-piperidyl)-phenyl-methanone hydrochloride is influenced by several factors, including its ionic nature, molecular weight, and the properties of the solvent used. Here are some key points to consider:

  • Water Solubility: Being a hydrochloride salt, it is often more soluble in water compared to its free base form. This is due to the ionization effect in aqueous solutions.
  • Organic Solvents: The compound may exhibit varying degrees of solubility in organic solvents such as ethanol or methanol, depending on the solvent's polarity.
  • pH Influence: The solubility can be pH-dependent; changes in pH can either enhance or reduce solubility based on ionization states.
  • Temperature Effects: Increasing temperature generally enhances solubility for most salts, potentially allowing for better dissolution rates in solutions.

In practical applications, it is essential to consider these solubility characteristics for formulation methodologies and therapeutic effectiveness. For instance, a compound's solubility can dramatically affect its bioavailability, with higher solubility leading to increased absorption rates and improved efficacy.

Overall, understanding the solubility profile of (4-hydroxy-1-methyl-4-phenyl-3-piperidyl)-phenyl-methanone hydrochloride is crucial for its application in pharmaceutical formulations and drug delivery systems.

Interesting facts

Interesting Facts about (4-hydroxy-1-methyl-4-phenyl-3-piperidyl)-phenyl-methanone hydrochloride

(4-hydroxy-1-methyl-4-phenyl-3-piperidyl)-phenyl-methanone hydrochloride, often abbreviated due to its lengthy name, is a compound of great interest in the field of medicinal chemistry. Here are some intriguing insights:

  • Pharmaceutical Significance: This compound is primarily studied for its potential therapeutic applications. Its structure suggests it may interact positively with various biological pathways, making it a candidate for drug development.
  • Analgesic Properties: Research indicates that derivatives related to this compound have shown promise in providing pain relief, potentially leading to the development of new analgesics that could offer fewer side effects compared to traditional options.
  • Complex Structure: The unique incorporation of a piperidine ring, alongside phenyl and hydroxyl groups, exemplifies the versatility of organic synthesis and the intricate design of compounds aimed at modulating biological functions.
  • Pharmacophore: The molecular arrangement of (4-hydroxy-1-methyl-4-phenyl-3-piperidyl)-phenyl-methanone hydrochloride exemplifies a novel pharmacophore, making it a crucial subject of study for understanding ligand-receptor interactions in drug design.
  • Research Potential: The ongoing investigation into compounds like this one aligns with the broader goals of the scientific community to develop innovative treatments for various diseases, particularly in targeting pain management and neurological conditions.

As a result, the potential for (4-hydroxy-1-methyl-4-phenyl-3-piperidyl)-phenyl-methanone hydrochloride to contribute to advancements in medicinal chemistry cannot be overstated. With ongoing research, this compound may one day play a pivotal role in the development of more effective pharmacological agents.

Synonyms
4661-15-8
1-Methyl-4-phenyl-4-hydroxy-3-benzoylpiperidine hydrochloride
NU-813
KETONE, (4-HYDROXY-1-METHYL-4-PHENYL-3-PIPERIDYL) PHENYL, HYDROCHLORIDE
Methanone, (4-hydroxy-1-methyl-4-phenyl-3-piperidinyl)phenyl-, hydrochloride
DTXSID40963620
3-benzoyl-1-methyl-4-phenyl-4-piperidinol hydrochloride
(4-Hydroxy-1-methyl-4-phenylpiperidin-3-yl)(phenyl)methanone--hydrogen chloride (1/1)