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Uracil

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Identification
Molecular formula
C4H4N2O2
CAS number
66-22-8
IUPAC name
4-hydroxy-1H-pyrimidin-6-one
State
State

Uracil is typically solid at room temperature.

Melting point (Celsius)
335.00
Melting point (Kelvin)
608.15
Boiling point (Celsius)
386.60
Boiling point (Kelvin)
659.75
General information
Molecular weight
112.09g/mol
Molar mass
112.0860g/mol
Density
1.3230g/cm3
Appearence

Uracil appears as a white solid with crystalline structure. It lacks color and has a slightly sweet inoffensive odor. It is a key component in the nucleic acid RNA.

Comment on solubility

Solubility of 4-hydroxy-1H-pyrimidin-6-one

4-hydroxy-1H-pyrimidin-6-one exhibits intriguing solubility properties that are influenced by several factors. Understanding its solubility is crucial for its applications in various fields. Here are some key points to consider:

  • Polarity: The presence of the hydroxyl group (-OH) contributes to the compound's polarity, making it more soluble in polar solvents such as water.
  • Hydrogen Bonding: The hydroxyl group can engage in hydrogen bonding with water molecules, which enhances its solubility in aqueous environments.
  • Solvent Interaction: Solubility may vary in different solvents; for example, it may show reduced solubility in non-polar organic solvents like hexane.
  • Temperature Dependency: Like many compounds, the solubility of 4-hydroxy-1H-pyrimidin-6-one may increase with temperature, allowing for more effective dissolution in heated solvents.

In summary, 4-hydroxy-1H-pyrimidin-6-one is relatively soluble in polar solvents due to its chemical structure and functional groups. However, detailed solubility studies should be conducted to fully understand the extent of its solubility in various mediums. As the saying goes, "Knowing the medium is key to mastering solubility!"

Interesting facts

Overview of 4-hydroxy-1H-pyrimidin-6-one

4-hydroxy-1H-pyrimidin-6-one, also known as a derivative of pyrimidine, is a fascinating compound with intriguing chemical properties and potential applications. This compound has garnered interest in various fields of chemistry due to its unique structure and biological significance.

Chemical Structure and Properties

The molecular structure of 4-hydroxy-1H-pyrimidin-6-one features:

  • A pyrimidine ring, which is a six-membered ring containing nitrogen atoms.
  • A hydroxyl group (-OH) attached to the fourth position of the pyrimidine ring.
  • A carbonyl group (=O) at the sixth position, contributing to the compound's reactivity.

Biological Significance

This compound is particularly noteworthy due to its potential role in:

  • Antimicrobial Activity: Some studies suggest that derivatives of pyrimidinones can exhibit antimicrobial properties, making them candidates for further drug development.
  • Enzyme Inhibition: Their structural components may inhibit certain enzymes, thereby impacting numerous biochemical pathways.

Applications and Uses

4-hydroxy-1H-pyrimidin-6-one is utilized in various research applications:

  • As an intermediate in the synthesis of other bioactive compounds.
  • In medicinal chemistry for developing potential therapeutic agents.

Quote from a Research Study

As a researcher might put it, "The exploration of pyrimidine derivatives like 4-hydroxy-1H-pyrimidin-6-one opens new avenues in drug discovery and development, providing essential insights into biochemical mechanisms.”

In conclusion, the study of 4-hydroxy-1H-pyrimidin-6-one reveals its importance in both fundamental and applied chemistry. Its unique structural features and biological implications make it a compound of great interest for ongoing research and development in medicinal and organic chemistry.

Synonyms
4,6-DIHYDROXYPYRIMIDINE
1193-24-4
4,6-Pyrimidinediol
4(3H)-Pyrimidinone, 6-hydroxy-
4(1H)-Pyrimidinone, 6-hydroxy-
6-hydroxypyrimidin-4(3H)-one
6-Hydroxy-4-pyrimidinone
6-Hydroxy-1H-pyrimidin-4-one
4,6-Dihydroxypyrimidin
NSC 22838
4,6-Dihydroxypyrimidin [German]
EINECS 214-772-3
NSC-22838
6L93V0S662
EC 214-772-3
HYDROXY-4(1H)-PYRIMIDINONE, 6-
4,6pyrimidinediol
4,6Dihydroxypyrimidin
6Hydroxy1Hpyrimidin4one
6Hydroxy4(1H)pyrimidinone
4(1H)Pyrimidinone, 6hydroxy
4(3H)Pyrimidinone, 6hydroxy
pyrimidine-4,6-diol
4-hydroxy-1H-pyrimidin-6-one
6-Hydroxy-4(1H)-pyrimidinone
MFCD00016733
UNII-6L93V0S662
NSC22838
PYRIMIDINE, 4,6-DIHYDROXY-
6-hydroxy-3,4-dihydropyrimidin-4-one
4,6-dihydroxy pyrimidine
4,6-Pyrimidinediol; 6-Hydroxy-1H-pyrimidin-4-one
6-hydroxy-4(3h)-pyrimidone
MLS000774924
SCHEMBL152294
6-hydroxy-3H-pyrimidin-4-one
SCHEMBL8088423
4,6-Dihydroxypyrimidine, 98%
CHEMBL1722176
DTXSID6025434
DUFGYCAXVIUXIP-UHFFFAOYSA-
CHEBI:184008
HMS2744P17
BCP00979
pyrimidin-4(1H)-one, 6-hydroxy-
STR03284
STL135950
STL139315
AKOS003237466
AKOS005746727
AC-2511
CS-W016618
FD11328
HY-W015902
PS-3433
SB57283
NCGC00246132-01
SMR000368133
SY001718
DB-016046
D1821
NS00008902
EN300-25578
AB-323/25048196
AC-907/25014023
Q27265097
Z56766633
F0176-0211
InChI=1/C4H4N2O2/c7-3-1-4(8)6-2-5-3/h1-2H,(H2,5,6,7,8)