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Meloxicam

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Identification
Molecular formula
C14H13N3O4S2
CAS number
71125-38-7
IUPAC name
4-hydroxy-2-(4-methoxyphenyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide
State
State

At room temperature, meloxicam is in its solid state, appearing as a powder used in pharmaceutical preparations.

Melting point (Celsius)
255.00
Melting point (Kelvin)
528.15
Boiling point (Celsius)
622.80
Boiling point (Kelvin)
895.95
General information
Molecular weight
351.40g/mol
Molar mass
351.4040g/mol
Density
1.5196g/cm3
Appearence

Meloxicam is a light-yellow solid that appears as a crystalline powder. It is often available as tablets or capsules, owing to its medicinal use. The substance is typically pale yellow to greenish yellow in color.

Comment on solubility

Solubility of 4-hydroxy-2-(4-methoxyphenyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide

The solubility of the compound 4-hydroxy-2-(4-methoxyphenyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide (C14H13N3O4S2) can be interesting to study, particularly due to its complex structure. Several factors play a role in the solubility of this compound:

  • Polarity: The presence of functional groups such as hydroxyl (-OH) and sulfonamide (-SO2NH2) likely contributes to its polar nature, potentially enhancing its solubility in polar solvents.
  • Hydrophobic Interactions: The methoxy (-OCH3) group and thieno[3,2-e]thiazine ring may introduce hydrophobic interactions, which could limit solubility in water but improve solubility in organic solvents.
  • Temperature Effects: Solubility can significantly change with temperature; increasing temperature often enhances the solubility of many compounds.
  • pH Dependency: The compound's solubility may also be influenced by the pH of the solution due to possible protonation or deprotonation of certain functional groups.

In summary, while the exact solubility of this compound can vary based on the solvent and conditions, it can be generally presumed that:

  1. It may show higher solubility in polar organic solvents.
  2. Solubility in water might be limited due to hydrophobic regions.

Understanding these aspects of solubility is crucial for applications in pharmaceuticals and chemical formulations, where solubility can greatly affect bioavailability and efficacy.

Interesting facts

Interesting Facts about 4-hydroxy-2-(4-methoxyphenyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide

This compound, known for its complex structure, falls into the category of thiazine derivatives, which have gained interest in medicinal chemistry. Below are some intriguing aspects that highlight its significance:

  • Pharmacological Potential: Research has indicated that thiazine derivatives can exhibit various biological activities, including antimicrobial and antiviral properties. This specific compound's structure suggests potential efficacy as a therapeutic agent.
  • Sulfonamide Backbone: The sulfonamide group is known for its role in the development of antibiotics. This compound's sulfonamide moiety not only enhances its solubility but also contributes to its biological activity, making it a topic of interest in drug design.
  • Aromatic Nature: The presence of the 4-methoxyphenyl group adds an aromatic characteristic that may influence the compound's interaction with biological targets, potentially enhancing its activity by allowing for π-π stacking interactions with biomolecules.
  • Diversity in Synthesis: The synthesis of this compound involves multiple chemical transformation steps, providing a platform for researchers to investigate new reaction pathways and optimize yields. Its synthesis may also serve as a model for creating other pharmaceuticals.
  • Research in Material Science: Beyond its biological implications, compounds with thiazine structures are being explored for their roles in material science, particularly in the development of sensors and organic semiconductors.
  • Complexity Meets Function: With the intricate arrangement of nitrogen and sulfur atoms, this compound exemplifies how complex chemical structures can lead to diverse functionalities, inspiring future studies centered around similar architectures.

In summary, 4-hydroxy-2-(4-methoxyphenyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide represents a fascinating intersection of organic chemistry, pharmacology, and material science, continuously prompting scientific inquiry and innovation.

Synonyms
SCHEMBL678716
BDBM11933
4-hydroxy-2-(4-methoxyphenyl)-1,1-dioxo-2H,3H,4H-1$l^{6},7,2-thieno[3,2-e][1,2]thiazine-6-sulfonamide