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Bromhexine

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Identification
Molecular formula
C14H20BrNO2S2
CAS number
611-75-6
IUPAC name
[4-[hydroxy-bis(2-thienyl)methyl]cyclohexyl]-trimethyl-ammonium;bromide
State
State

At room temperature, Bromhexine is typically found in a solid state.

Melting point (Celsius)
194.00
Melting point (Kelvin)
467.00
Boiling point (Celsius)
230.00
Boiling point (Kelvin)
503.00
General information
Molecular weight
412.37g/mol
Molar mass
412.3670g/mol
Density
1.2986g/cm3
Appearence

Bromhexine typically appears as a crystalline substance. It is colorless or white and has a characteristic smell.

Comment on solubility

Solubility of 4-[hydroxy-bis(2-thienyl)methyl]cyclohexyl-trimethyl-ammonium bromide

The compound 4-[hydroxy-bis(2-thienyl)methyl]cyclohexyl-trimethyl-ammonium bromide demonstrates intriguing solubility characteristics due to its unique structure and ionic nature. Here are some key points regarding its solubility:

  • Ionic Interaction: As a quaternary ammonium salt, it readily dissociates in aqueous solutions, leading to enhanced solubility in polar solvents.
  • Hydrophilic Groups: The presence of both hydroxy and ammonium functional groups contributes significantly to its solubility, enabling strong interactions with water molecules.
  • Solvent Compatibility: This compound demonstrates better solubility in polar solvents compared to non-polar solvents, making it suitable for various applications in aqueous media.

It is often noted that "the solubility of a compound is determined by the balance between hydrophilic and hydrophobic interactions." In the case of this compound, the hydrophilic ammonium group enhances its solubility in water, while the hydrophobic cyclohexyl and thienyl moieties can influence solubility in organic solvents.
Thus, its solubility profile can be particularly useful when considering its potential applications in different chemical environments.

Interesting facts

Interesting Facts about 4-[Hydroxy-bis(2-thienyl)methyl]cyclohexyl-trimethyl-ammonium Bromide

This fascinating compound, often referred to simply as a quaternary ammonium salt, is notable for its unique structural features and potential applications. Here are some interesting aspects:

  • Quaternary Ammonium Structure: Comprising a nitrogen atom bonded to four organic groups, quaternary ammonium compounds are known for their surfactant properties, making them essential in various industrial and laboratory settings.
  • Thienyl Rings: The presence of two thienyl groups confers unique electronic and chemical properties to the compound. These heterocyclic rings can enhance the compound's interactions with biological systems and materials.
  • Potential Applications: Due to its structure, this compound may find uses in:
    • Biological Research: As a potential chemical probe or therapeutic agent, offering insights into synaptic transmission or drug delivery systems.
    • Materials Science: Its surfactant properties could lead to innovations in polymer formulations and coatings.
  • Inhibition of Microbial Growth: Similar quaternary ammonium compounds are frequently studied for their antimicrobial properties, offering potential as disinfectants or preservatives.
  • Synthesis and Functionality: The synthesis of compounds like this one typically involves advanced organic chemistry techniques, making them an exciting topic for chemistry students and researchers alike.

Overall, 4-[Hydroxy-bis(2-thienyl)methyl]cyclohexyl-trimethyl-ammonium bromide is a compound that not only exemplifies the diversity of chemical structures but also suggests promising avenues for further exploration in both scientific research and practical applications.

Synonyms
THIHEXINOL METHYLBROMIDE
7219-91-2
Methyl thihexinolium bromide
03CPZ5439O
[4-[hydroxy(dithiophen-2-yl)methyl]cyclohexyl]-trimethylazanium;bromide
(4-(Hydroxydi-2-thienylmethyl)cyclohexyl)trimethylammonium bromide
UNII-03CPZ5439O
Thihexinol methylbromide [INN:NF]
Metilbromuro de tihexinol
Methylbromure de thihexinol
SCHEMBL2733290
CHEMBL2107680
DTXSID10992907
THIHEXINOL METHYLBROMIDE [INN]
NS00126100
Q27247551
4-[Hydroxydi(thiophen-2-yl)methyl]-N,N,N-trimethylcyclohexan-1-aminium bromide