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Nitrofurantoin

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Identification
Molecular formula
C8H6N4O5
CAS number
67-20-9
IUPAC name
4-hydroxy-N-[(5-nitro-2-furyl)methyleneamino]benzamide
State
State

At room temperature, nitrofurantoin is in a solid state, typically found as a crystalline powder.

Melting point (Celsius)
253.00
Melting point (Kelvin)
526.15
Boiling point (Celsius)
221.90
Boiling point (Kelvin)
495.05
General information
Molecular weight
238.16g/mol
Molar mass
238.1560g/mol
Density
1.6609g/cm3
Appearence

Nitrofurantoin appears as a yellow crystalline powder.

Comment on solubility

Solubility of 4-hydroxy-N-[(5-nitro-2-furyl)methyleneamino]benzamide

The solubility of 4-hydroxy-N-[(5-nitro-2-furyl)methyleneamino]benzamide can be quite intriguing due to its complex structure. Understanding the solubility characteristics of this compound is essential in predicting its behavior in different environments. Here are some key points to consider:

  • Polarity: The presence of hydroxyl (–OH) and nitro (–NO2) groups increases the polarity of the molecule, which may enhance its solubility in polar solvents.
  • Hydrogen Bonding: With both hydrogen bond donors (like the hydroxyl group) and acceptors (like the nitro group), this compound can form hydrogen bonds with water, potentially increasing its solubility in aqueous solutions.
  • Solvent Compatibility: It is likely to be more soluble in polar solvents such as methanol or ethanol compared to non-polar solvents like hexane. This could be advantageous for various practical applications including drug formulation.
  • Temperature Dependence: As with many organic compounds, the solubility may increase with temperature, which is a vital consideration for processes that involve heating.

In summary, the solubility of 4-hydroxy-N-[(5-nitro-2-furyl)methyleneamino]benzamide appears to be influenced by its molecular structure, including effects of hydrogen bonding and polarity. Understanding these factors can provide valuable insights into how this compound may behave in different chemical systems.

Interesting facts

Interesting Facts about 4-Hydroxy-N-[(5-nitro-2-furyl)methyleneamino]benzamide

4-Hydroxy-N-[(5-nitro-2-furyl)methyleneamino]benzamide, commonly referred to in chemical research as a nitrofuran derivative, has piqued the interest of scientists and researchers due to its unique properties and potential applications. Here are some intriguing aspects of this compound:

  • Antimicrobial Activity: Compounds containing the nitrofuran group are often studied for their activities against various microorganisms. This particular compound has been noted for its potential antibacterial properties, which could lead to novel therapeutic agents.
  • Synthetic Pathways: The synthesis of this compound involves intriguing organic reactions such as the formation of imine linkages. This makes it a valuable subject for textbook studies on organic synthesis and reaction mechanisms.
  • Pharmacological Potential: Research is ongoing into the pharmacological implications of this compound. As a promising candidate, its structure could be manipulated to enhance efficacy or reduce toxicity in drug development.
  • Heterocyclic Chemistry: The presence of the furan ring embedded within the compound showcases the rich field of heterocyclic chemistry. Heterocycles are essential in pharmaceuticals and understanding their impact on biological systems.
  • Role in Cancer Research: Some studies suggest that derivatives of this compound may play a role in cancer treatment. The functional groups present in its structure can be pivotal in modifying interactions with biological targets.

Conclusion

As research progresses, 4-hydroxy-N-[(5-nitro-2-furyl)methyleneamino]benzamide may offer significant insights into medicinal chemistry and organic synthesis. Its multifaceted characteristics make it a compelling subject for ongoing exploration, potentially leading to groundbreaking discoveries in the field.

Synonyms
Akabar
SR-01000721893
MFCD00079482
Prestwick0_000555
Prestwick1_000555
CBMicro_014685
SPBio_002550
CHEMBL1309180
HMS2230L10
HMS3372F20
HMS3652F07
AKOS025117034
SY102095
DB-057635
N1181
NS00007819
SR-01000721893-2
SR-01000721893-3
4-hydroxybenzoic [(5-nitro-2-furanyl) methylene]hydrazide