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4-Iodobenzenesulfonamide

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Identification
Molecular formula
C6H6INO2S
CAS number
98-05-5
IUPAC name
4-iodobenzenesulfonamide
State
State

At room temperature, 4-iodobenzenesulfonamide is typically found in a solid state.

Melting point (Celsius)
178.00
Melting point (Kelvin)
451.15
Boiling point (Celsius)
375.00
Boiling point (Kelvin)
648.15
General information
Molecular weight
281.08g/mol
Molar mass
281.0790g/mol
Density
2.0000g/cm3
Appearence

4-Iodobenzenesulfonamide is a crystalline solid that is often white to off-white in color. It may be available in powdered form or as small crystals, depending on the synthesis and purification process.

Comment on solubility

Solubility of 4-Iodobenzenesulfonamide

4-Iodobenzenesulfonamide, with the chemical formula C6H6I N O2S, exhibits distinctive solubility characteristics. Understanding its solubility is crucial for various applications in the fields of chemistry and pharmacology.

Solubility Highlights:

  • Polarity: The presence of the sulfonamide group enhances polarity, promoting solubility in polar solvents.
  • Solvents: It is known to be soluble in:
    • Water
    • Dimethyl sulfoxide (DMSO)
    • Ethanol
  • Temperature Effect: Solubility may increase with temperature, so heating can often facilitate dissolution.
  • Ion Formation: In aqueous solutions, the ionization of the sulfonamide group may significantly enhance solubility.

In summary, the solubility of 4-iodobenzenesulfonamide can be influenced by factors such as polarity, solvent choice, temperature, and the formation of ions. As a rule of thumb, "like dissolves like," making it essential to choose the right solvent for optimal solubility. Always consider these factors in experimental setups or applications involving this interesting compound.

Interesting facts

Interesting Facts about 4-Iodobenzenesulfonamide

4-Iodobenzenesulfonamide is a fascinating compound that occupies a unique space in the realm of chemical sciences, particularly in medicinal chemistry and the development of pharmaceuticals. Here are some notable facts:

  • Pharmaceutical Relevance: This compound is particularly significant due to its role as a sulfonamide, a class of drugs known for their antibacterial properties. It has been used as a precursor for developing various therapeutic agents.
  • Mechanism of Action: Compounds like 4-iodobenzenesulfonamide often work by inhibiting bacterial folic acid synthesis, which is essential for bacterial growth and replication. This mechanism effectively helps to treat infections.
  • Research Application: The compound is also utilized in various chemical research studies, which explore substitution patterns on the aromatic ring. This can lead to new insights into structure-activity relationships in drug design.
  • Iodination Benefits: The presence of iodine in its structure is noteworthy as it can enhance the compound's biological activity and properties, making it a subject of interest for radiochemistry applications.
  • Analytical Studies: 4-Iodobenzenesulfonamide can be studied using various analytical techniques such as NMR and mass spectrometry, providing valuable data on its molecular structure and interactions.

As a compound rich in both historical and contemporary significance, 4-iodobenzenesulfonamide serves as a reminder of the intricate link between chemistry and medicine. “The study of compounds is crucial for the advancement of fields such as pharmacology and materials science,” states many chemical researchers. This compound exemplifies that interconnectedness through its diverse applications and intriguing properties.

Synonyms
4-IODOBENZENESULFONAMIDE
825-86-5
p-Iodobenzenesulfonamide
4-iodobenzene-1-sulfonamide
Benzenesulfonamide, p-iodo-
BRN 2691658
DTXSID50231802
3-11-00-00110 (Beilstein Handbook Reference)
DTXCID40154293
842-629-0
4-Iodobenzenesulphonamide
Benzenesulfonamide,4-iodo-
p-Jodbenzolsulfonamid
MFCD00092887
4-iodo-benzenesulfonamide
4-iodo-1-sulfamoylbenzene
A1H6X
SCHEMBL1008930
BDBM81919
KQZFABSTXSNEQH-UHFFFAOYSA-N
p-Halide-sulfanilamide derivative, 3
AKOS005139310
FI67449
PS-4552
SB82245
DB-184985
CS-0187021
E78269
EN300-135556
Z300170034