Skip to main content

4-Iodobenzoic acid

ADVERTISEMENT
Identification
Molecular formula
C7H5IO2
CAS number
619-58-9
IUPAC name
4-iodobenzoic acid
State
State

At room temperature, 4-iodobenzoic acid is in a solid-state. It is stable under normal conditions but should be stored in tightly closed containers to prevent moisture uptake.

Melting point (Celsius)
294.00
Melting point (Kelvin)
567.15
Boiling point (Celsius)
315.00
Boiling point (Kelvin)
588.15
General information
Molecular weight
248.02g/mol
Molar mass
248.0220g/mol
Density
2.0071g/cm3
Appearence

4-Iodobenzoic acid appears as a white crystalline solid. The compound is typically composed of fine, needle-like crystals and is highly pure, commonly available in a powder form.

Comment on solubility

Solubility of 4-Iodobenzoic Acid

4-Iodobenzoic acid, with the chemical formula C7H5IO2, presents interesting solubility characteristics that are worth discussing.

When we consider the solubility of this compound, it can be summarized as follows:

  • Polar solubility: Due to the presence of the carboxylic acid group (-COOH), 4-iodobenzoic acid is more soluble in polar solvents such as water compared to non-polar solvents.
  • Temperature dependence: Like many organic acids, its solubility generally increases with temperature, making it more soluble in warm solvents.
  • Formation of salts: The acidic nature allows 4-iodobenzoic acid to react with bases, forming soluble salts, which can enhance its overall solubility in solution.
  • Influence of substituents: The iodine substituent increases the hydrophobic character of the compound, which may reduce its solubility in strongly polar solvents when compared to unsubstituted benzoic acid.

In conclusion, “while 4-iodobenzoic acid is predominantly soluble in polar solvents, the degree of solubility is influenced by numerous factors such as temperature and the presence of other ions or molecules in solution.”

Interesting facts

Interesting Facts About 4-Iodobenzoic Acid

4-Iodobenzoic acid is a fascinating compound that falls within the category of aromatic carboxylic acids. Here are some interesting insights about this compound:

  • Structure and Functionality: As a derivative of benzoic acid, it features an iodine atom located at the para position relative to the carboxylic acid functional group. This strategic positioning greatly influences its reactivity and interactions.
  • Reactivity: The iodine substituent provides unique properties, making 4-iodobenzoic acid valuable in various chemical reactions, such as nucleophilic substitutions and coupling reactions. This lends itself well to applications in synthetic organic chemistry.
  • Molecular Significance: Due to the presence of iodine, 4-iodobenzoic acid demonstrates unique properties, including the ability to participate in electrophilic aromatic substitutions. The compound is often utilized in the synthesis of pharmaceuticals and dyes, showcasing its versatility in chemical synthesis.
  • Therapeutic Potential: Studies have found that derivatives of 4-iodobenzoic acid exhibit interesting biological activities. They have potential use as anti-inflammatory agents and in the development of therapeutic drugs, making them subjects of ongoing pharmacological research.

Applications in Research

The compound is also utilized as a reagent in research, facilitating the creation of various other compounds that can be used in different scientific explorations. It serves as a starting point for the synthesis of:

  • More complex organic molecules
  • Ligands in coordination chemistry
  • Targeting modifications in biochemical pathways

In conclusion, 4-iodobenzoic acid is more than just a simple aromatic compound; it holds great potential in both synthetic chemistry and pharmaceutical development. As science continues to advance, this compound will likely play a vital role in future innovations and discoveries.

Synonyms
4-IODOBENZOIC ACID
Benzoic acid, 4-iodo-
Benzoic acid, p-iodo-
p-Iodobenzenecarboxylic acid
4-Jodbenzoesaeure
4-Jodbenzoesaeure [German]
IPO4LYQ1EN
UNII-IPO4LYQ1EN
NSC 3773
EINECS 210-603-2
BRN 1860232
NSC-3773
IODOBENZOIC ACID, P-
DTXSID20862304
NSC-176127
4Jodbenzoesaeure
para-iodobenzoate
pIodobenzoic acid
Benzoic acid, piodo
Benzoic acid, 4iodo
pIodobenzenecarboxylic acid
(125I)-para-iodobenzoate
4-iodobenzoic acid, 125I-
DTXCID20198473
210-603-2
4-27-00-07537 (beilstein handbook reference)
ghiccuxqjbdnrn-uhfffaoysa-n
inchi=1/c7h5io2/c8-6-3-1-5(2-4-6)7(9)10/h1-4h,(h,9,10
619-58-9
p-Iodobenzoic acid
4-Iodo-benzoic acid
MFCD00002533
CHEMBL101265
4-Iodobenzoicacid
p-Iodo-benzoic acid
4 -iodobenzoic acid
4-iodo benzoic acid
para-iodobenzoic acid
4-Iodobenzoic acid, 98%
SCHEMBL79334
NSC3773
BDBM50405325
STK256891
AKOS000118868
CS-W014112
FI12178
HY-W013396
MF-0039
AC-22933
SY001356
DB-014490
I0054
NS00043097
EN300-18256
D70923
4-Iodobenzoic acid, purum, >=97.0% (HPLC)
AE-562/42923958
Q27280838
Z57636572
F2191-0085
KZ6