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Trimethobenzamide hydrochloride

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Identification
Molecular formula
C21H26ClN3O4
CAS number
138-56-7
IUPAC name
[4-(m-tolylmethyl)piperazin-4-ium-1-yl]-(3,4,5-trimethoxyphenyl)methanone;chloride
State
State

At room temperature, Trimethobenzamide hydrochloride is in a solid state, typically manifested as a fine powder.

Melting point (Celsius)
103.00
Melting point (Kelvin)
376.15
Boiling point (Celsius)
275.00
Boiling point (Kelvin)
548.15
General information
Molecular weight
375.90g/mol
Molar mass
375.8700g/mol
Density
1.2007g/cm3
Appearence

Trimethobenzamide hydrochloride appears as a white to off-white crystalline powder. It is often supplied in a powdered form for medical applications, particularly as an antiemetic.

Comment on solubility

Solubility of [4-(m-tolylmethyl)piperazin-4-ium-1-yl]-(3,4,5-trimethoxyphenyl)methanone;chloride

The solubility of the compound [4-(m-tolylmethyl)piperazin-4-ium-1-yl]-(3,4,5-trimethoxyphenyl)methanone;chloride can be influenced by various factors due to its complex structure. Understanding its solubility characteristics is crucial for potential applications and formulations. Here are some key aspects to consider:

  • Polarity: The presence of the piperazine ring and the trimethoxy groups suggest that the compound may exhibit both polar and non-polar characteristics, which can affect interactions with solvents.
  • Solvent Compatibility: It is likely to be soluble in polar solvents like water and methanol, but may show limited solubility in non-polar solvents due to its ionic nature.
  • Temperature Dependence: Solubility can also change with temperature. Higher temperatures generally enhance the solubility of solutes in solvents.
  • pH Influence: As a quaternary ammonium salt, its solubility might be pH-dependent, with possible variations in solubility across different pH levels.

In conclusion, the solubility of [4-(m-tolylmethyl)piperazin-4-ium-1-yl]-(3,4,5-trimethoxyphenyl)methanone;chloride is multifaceted and could vary significantly depending on the solvent medium and environmental conditions. Understanding these properties is essential for targeted applications in pharmaceuticals and chemical synthesis.

Interesting facts

Interesting Facts About [4-(m-tolylmethyl)piperazin-4-ium-1-yl]-(3,4,5-trimethoxyphenyl)methanone; Chloride

The compound known as [4-(m-tolylmethyl)piperazin-4-ium-1-yl]-(3,4,5-trimethoxyphenyl)methanone; chloride is a fascinating example of complex organic chemistry. This cationic compound features a piperazine ring, which is a common structure in medicinal chemistry due to its efficacy in a variety of pharmacological applications.

Key Features:

  • Biological Relevance: Compounds containing piperazine moieties are often found in numerous pharmaceutical agents, particularly in treating conditions such as anxiety, depression, and even certain cancers.
  • Functional Groups: The presence of the methanone and methoxy groups in this molecule indicates potential reactivity in organic synthesis and drug development, contributing to unique interaction profiles with biological targets.
  • Structural Diversity: The molecule's structure combines a piperazine core with a trimethoxyphenyl group, showcasing the versatility of organic synthesis in creating diverse chemical entities with tailored properties.

Furthermore, the introduction of the chloride counterion not only enhances the compound's solubility in various solvents but may also influence its biological activity. As chemists delve deeper into the synthesis and characterization of such compounds, they unlock a wealth of opportunities for new drug discoveries.

In the words of renowned chemist Lord Kelvin, "If you can not measure it, you can not improve it." This quote resonates with the ongoing research into the therapeutic potential of compounds like [4-(m-tolylmethyl)piperazin-4-ium-1-yl]-(3,4,5-trimethoxyphenyl)methanone; chloride, where quantitative analysis will guide future advancements in medicinal chemistry.

Synonyms
17766-61-9
1-(m-Methylbenzyl)-4-(3,4,5-trimethoxybenzoyl)piperazine hydrochloride
4-(m-Methylbenzyl)piperazinyl 3,4,5-trimethoxyphenyl ketone hydrochloride
Piperazine, 1-(m-methylbenzyl)-4-(3,4,5-trimethoxybenzoyl)-, hydrochloride
KETONE, 4-(m-METHYLBENZYL)PIPERAZINYL 3,4,5-TRIMETHOXYPHENYL, HYDROCHLORIDE