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TFMPP

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Identification
Molecular formula
C20H24N2O4
CAS number
83200-09-1
IUPAC name
[4-(m-tolyl)piperazin-1-yl]-(3,4,5-trimethoxyphenyl)methanone
State
State

At room temperature, TFMPP is typically found in a solid state. It is usually stored and handled as a crystalline powder.

Melting point (Celsius)
127.50
Melting point (Kelvin)
400.60
Boiling point (Celsius)
487.60
Boiling point (Kelvin)
760.80
General information
Molecular weight
324.42g/mol
Molar mass
324.3850g/mol
Density
1.1735g/cm3
Appearence

TFMPP is a white crystalline solid. Its crystals are generally fine and can be readily dissolved in various organic solvents.

Comment on solubility

Solubility of [4-(m-tolyl)piperazin-1-yl]-(3,4,5-trimethoxyphenyl)methanone

The solubility of [4-(m-tolyl)piperazin-1-yl]-(3,4,5-trimethoxyphenyl)methanone can be quite fascinating due to its intricate structure. Generally, the solubility of such compounds is influenced by several factors:

  • Polarity: The presence of multiple methoxy groups contributes to the overall polarity, which can enhance solubility in polar solvents.
  • Hydrogen Bonding: The piperazine ring may participate in hydrogen bonding, affecting solubility. Compounds capable of hydrogen bonding often exhibit better solubility in protic solvents.
  • Solvent Interaction: Solubility is highly dependent on the choice of solvent. The compound may dissolve readily in organic solvents like methanol or dimethyl sulfoxide (DMSO), while exhibiting lower solubility in non-polar solvents.

As with many complex organic compounds, it could be said that “the solubility of a substance cannot be understood without considering its molecular structure.” This hints at the importance of studying solubility on a case-by-case basis, taking into account the unique attributes of each compound.

In summary, while [4-(m-tolyl)piperazin-1-yl]-(3,4,5-trimethoxyphenyl)methanone may show promising solubility characteristics in various solvents, specific empirical data would provide more insight into its practical solubility behavior under different conditions.

Interesting facts

Interesting Facts about [4-(m-tolyl)piperazin-1-yl]-(3,4,5-trimethoxyphenyl)methanone

This intriguing compound is a member of the piperazine class, which is widely recognized for its applications in pharmaceuticals and bioactive molecules. Its structural complexity offers a fascinating glimpse into the world of medicinal chemistry, wherein slight modifications in molecular frameworks can lead to significant changes in biological activities.

Key Features of the Compound:

  • Multi-functional Groups: The presence of various functional groups, such as the methoxy groups attached to the aromatic ring, contributes to the compound's potential for diverse reactivity and interactions.
  • Biological Relevance: Compounds similar to this one have been explored for their activities as antidepressants, antipsychotics, and anxiolytics, showcasing the importance of the piperazine moiety in drug development.
  • Structure-Activity Relationship: The piperazine ring, along with the m-tolyl substitution, illustrates the concept of structure-activity relationship (SAR), which is crucial in optimizing drug efficacy and minimizing side effects.
  • Research Interest: Ongoing studies on compounds like this one reveal their potential as templates for designing novel therapeutic agents.

Researchers often highlight that "modifying even a single atom can yield compounds with drastically different properties." This notion underscores the significance of studying compounds such as [4-(m-tolyl)piperazin-1-yl]-(3,4,5-trimethoxyphenyl)methanone, as it offers insights into how incorporating specific substituents shifts a compound's pharmacological profile.

In conclusion, this compound exemplifies the interplay between molecular design and biological function, embodying a world of possibilities within the realm of chemical science. Its ongoing study continues to shed light on the intricate balance between structure and activity in drug development.

Synonyms
BRN 1604643
1-(m-Tolyl)-4-(3,4,5-trimethoxybenzoyl)piperazine
17766-74-4
4-(m-Tolyl)piperazinyl 3,4,5-trimethoxyphenyl ketone
Piperazine, 1-(m-tolyl)-4-(3,4,5-trimethoxybenzoyl)-
KETONE, 4-(m-TOLYL)PIPERAZINYL 3,4,5-TRIMETHOXYPHENYL
5-23-01-00188 (Beilstein Handbook Reference)
[4-(3-methylphenyl)piperazin-1-yl](3,4,5-trimethoxyphenyl)methanone
DTXSID60938971
STL188584
AKOS016608444
Z165124402