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Berberine chloride

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Identification
Molecular formula
C20H18NO4Cl
CAS number
633-65-8
IUPAC name
4-methoxy-6-(4-methoxy-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinolin-6-ium-6-yl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-ol;chloride
State
State

At room temperature, berberine chloride is in a solid state, appearing as a crystalline powder.

Melting point (Celsius)
204.00
Melting point (Kelvin)
477.00
Boiling point (Celsius)
442.00
Boiling point (Kelvin)
715.00
General information
Molecular weight
371.83g/mol
Molar mass
371.8260g/mol
Density
1.3800g/cm3
Appearence

Berberine chloride typically appears as a yellow to brownish-yellow crystalline powder. It has a distinct, intense yellow color, which is characteristic of many alkaloids.

Comment on solubility

Solubility of 4-methoxy-6-(4-methoxy-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinolin-6-ium-6-yl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-ol; chloride

The solubility of 4-methoxy-6-(4-methoxy-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinolin-6-ium-6-yl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-ol; chloride can be influenced by various factors related to its chemical structure. This compound, characterized by its complex molecular framework, tends to exhibit the following solubility traits:

  • Polar Character: The presence of multiple hydroxyl groups and the chlorinated functional group generally suggests enhanced solubility in polar solvents such as water.
  • Solvent Selectivity: While it may be soluble in water, the specific solubility can vary significantly in organic solvents. For example, alcohols or dimethyl sulfoxide (DMSO) might accommodate the compound better due to hydrogen bonding capabilities.
  • pH Dependence: As the compound is a chloride salt, its solubility could be influenced by the pH of the solution; a more acidic environment may improve dissolution.
  • Temperature Sensitivity: Typically, the solubility aspects expand with temperature increase, allowing for more effective integration in higher-temperature solutions.

Overall, while the dynamics of solubility for this compound are relatively predictable due to its polar and ionic characteristics, experimental validation is always advisable to ascertain precise solubility in different solvents. As the saying goes, "the solution to your solubility questions lies in the solvent used!"

Interesting facts

Interesting Facts about 4-Methoxy-6-(4-methoxy-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinolin-6-ium-6-yl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-ol;chloride

This compound is a fascinating member of the isoquinoline family, which has garnered significant interest in pharmaceutical research due to its various biological activities. Below are some noteworthy aspects of this compound:

  • Isoquinoline Derivatives: Compounds derived from isoquinoline are known for their diverse pharmacological effects, including anti-inflammatory, analgesic, and antitumor properties. The unique structure of this compound, featuring multiple dioxole rings, adds to its potential therapeutic value.
  • Structure Complexity: The intricate arrangement of molecular components highlights the compound's complexity. It boasts multiple functional groups that could interact with various biological targets, making it a subject of interest for drug discovery.
  • Potential Applications: Given its structure, this compound could be explored for applications in treating neurological disorders, given isoquinoline's known activity in modulating neurotransmitter pathways.
  • Research Significance: As researchers continue to delve into the properties of such compounds, studies may reveal novel mechanisms of action or undiscovered medicinal benefits. This paves the way for new therapeutic agents.

In summary, the exploration of 4-methoxy-6-(4-methoxy-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinolin-6-ium-6-yl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-ol;chloride exemplifies the rich potential embedded within complex chemical structures. As science progresses, such compounds hold promise for advancing our understanding and treatment of various medical conditions.

Synonyms
5584-82-7
1,3-Dioxolo(4,5-g)isoquinolinium, 7,8-dihydro-6-(7,8-dihydro-5-hydroxy-4-methoxy-1,3-dioxolo(4,5-g)isoquinolin-6(5H)-yl)-4-methoxy-, chloride
DTXSID60971242
(5'-Hydroxy-4'-methoxy-7,7',8,8'-tetrahydro-2H,2'H,4H,5'H-[6,6'-bi[1,3]dioxolo[4,5-g]isoquinolin]-4-ylidene)(methyl)oxidanium chloride