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Narcotine

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Identification
Molecular formula
C22H23NO7
CAS number
128-62-1
IUPAC name
4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-ol
State
State
Narcotine is commonly found in a solid state at room temperature. It appears as a solid crystalline substance, reinforcing its stability at ambient conditions.
Melting point (Celsius)
176.00
Melting point (Kelvin)
449.15
Boiling point (Celsius)
365.00
Boiling point (Kelvin)
638.15
General information
Molecular weight
413.43g/mol
Molar mass
413.4340g/mol
Density
1.3000g/cm3
Appearence

Narcotine is generally observed as a white crystalline substance which may appear as a powder or as crystalline granules. It may also have a slightly yellowish tint depending on purity and environmental factors.

Comment on solubility

Solubility of 4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-ol

The solubility characteristics of 4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-ol can be quite intriguing. This compound, with its complex structure, often demonstrates varying solubility depending on the solvent used. Understanding its solubility is vital for practical applications such as formulation and synthesis. Here are some key points to consider:

  • Solvent Polarity: Solubility generally increases with solvent polarity. Polar solvents like water may dissolve the compound differently compared to non-polar solvents.
  • Hydrogen Bonding: The presence of hydroxyl groups can lead to strong hydrogen bonding interactions with solvents, enhancing solubility in polar environments.
  • Temperature Dependence: Solubility can be significantly affected by temperature; higher temperatures often improve solubility for many organic compounds.
  • Low Solubility: Given the complex structure and potential for aggregation, this compound may exhibit low solubility in common organic solvents.
  • Formulation Considerations: For pharmaceutical applications, the solubility profile can inform necessary modifications to improve bioavailability.

In summary, while 4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-ol may present challenges in terms of solubility, exploring various solvents and conditions can yield valuable insights for effective use. The statement "solubility is the key to bioavailability" rings particularly true in the context of this compound.

Interesting facts

Interesting Facts about 4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-ol

4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-ol is a fascinating compound that captivates chemists due to its unique structural features and potential applications. Here are some noteworthy points about this compound:

  • Structural Complexity: This compound showcases a remarkable fusion of isoquinoline and dioxole moieties, contributing to its intriguing chemical behavior. The presence of multiple rings and functional groups allows for diverse chemical reactivity.
  • Potential Pharmacological Activities: Like many isoquinoline derivatives, this compound may exhibit significant biological activities. Research suggests that isoquinoline derivatives can have effects such as anti-inflammatory, analgesic, and even anti-cancer properties.
  • Synthetic Versatility: The synthesis pathways for compounds with this structural framework are diverse, allowing chemists to explore various reaction conditions and modifications.
  • Diverse Applications: Compounds like this one may find their niche in pharmaceuticals, agrochemicals, or materials science due to their multifunctional potential.
  • Research Interest: The complexity and unique properties of this compound have gained the attention of many researchers eager to explore its synthesis and applications further. As a result, it provides a rich area for exploration in organic and medicinal chemistry.

Overall, 4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-ol serves as an impressive example of molecular design in chemistry, merging *structure* with potential *function*, inspiring innovative research and applications in various fields.

Synonyms
Cotarnine
82-54-2
COTARNIN
99781-53-0
4-Methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-ol
EINECS 201-429-8
UNII-79V56TDI6G
4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-ol
BRN 0022879
79V56TDI6G
4-methoxy-6-methyl-2H,5H,6H,7H,8H-[1,3]dioxolo[4,5-g]isoquinolin-5-ol
COTARNINE [MI]
MFCD00190616
COTARNINE [WHO-DD]
(+/-)-COTARNINE
5,6,7,8-Tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-ol
COTARNINE, (+/-)-
DTXSID80274484
4-27-00-06448 (Beilstein Handbook Reference)
1,3-Dioxolo(4,5-g)isoquinolin-5-ol, 5,6,7,8-tetrahydro-4-methoxy-6-methyl-
5,6,7,8-Tetrahydro-4-methoxy-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-ol
59760-32-6
4-Methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-ol
4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxol[4,5-g]isoquinolin-5-ol
4-methoxy-6-methyl-7,8-dihydro-5H-(1,3)dioxol(4,5-g)isoquinolin-5-ol
1,3-Dioxolo[4,5-g]isoquinolin-5-ol, 5,6,7,8-tetrahydro-4-methoxy-6-methyl-
1,3-Dioxolo[4,5-g]isoquinolin-5-ol,5,6,7,8-tetrahydro-4-methoxy-6-methyl-
SCHEMBL679713
CHEMBL4745550
DTXCID50225963
DTXSID40871559
CHEBI:166583
ALBB-028514
ZDA78153
NSC121978
STK693623
AKOS005605723
NSC-121978
NS-03227
XC160978
NS00041092
EN300-302336
SR-01000884006
SR-01000884006-1
Q27266783
1,3-Dioxolo(4,5-g)isoquinolin-5-ol, 5,6,7,8-tetrahydro-4-methoxy-6-methyl-(9CI)
4-Methoxy-6-methyl-5,6,7,8-tetrahydro-2H-[1,3]dioxolo[4,5-g]isoquinolin-5-ol
4-Methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-ol #
201-429-8
5, 6, 7, 8- Tetrahydro- 4- methoxy- 6- methyl-1, 3- Dioxolo[4, 5- g] isoquinolin- 5- ol