4-Methoxybenzenethiol | Solubility of Things

Identification

Molecular formula

C₇H₈OS

CAS number

696-59-3

IUPAC name

4-methoxybenzenethiol

State

4-Methoxybenzenethiol is typically a liquid at room temperature, though it is close to its melting point and can solidify upon cooling.

Melting point (Celsius)

32.00

Melting point (Kelvin)

305.15

Boiling point (Celsius)

244.00

Boiling point (Kelvin)

517.15

General information

Molecular weight

140.20g/mol

Molar mass

140.2030g/mol

Density

1.1480g/cm³

Appearence

4-Methoxybenzenethiol appears as a clear to slightly yellow liquid. It has a strong odor typical of thiol compounds, which is generally described as unpleasant and similar to the smell of rotten eggs, although the methoxy group can slightly modulate the odor profile.

Comment on solubility

Solubility of 4-Methoxybenzenethiol

4-Methoxybenzenethiol, also known as p-methoxythiophenol, is a compound that presents interesting solubility characteristics. Its solubility is primarily influenced by the presence of the methoxy group, which can engage in hydrogen bonding and modulate interactions with solvents. Here’s what makes its solubility noteworthy:

Solvent Compatibility: 4-Methoxybenzenethiol is generally soluble in organic solvents such as ethanol, methanol, and acetone due to its hydrophobic aromatic structure.
Water Solubility: The solubility in water is quite limited. The hydrophobic thiol and aromatic groups reduce its overall affinity for polar solvents.
Hydrogen Bonding: The methoxy group (-OCH₃) can engage in interactions with protic solvents, enhancing solubility to a degree.

In summary, while 4-methoxybenzenethiol is soluble in various organic solvents, its solubility in water is poor. To articulate its behavior, we might say:

"Its solubility profile is a balance of hydrophobic and hydrophilic interactions, leaning towards preference for non-polar environments."

Thus, understanding the solubility of 4-methoxybenzenethiol is crucial for applications in organic synthesis and other chemical processes.

Interesting facts

Interesting Facts About 4-Methoxybenzenethiol

4-Methoxybenzenethiol, also known as p-methoxybenzenethiol, is an aromatic compound that belongs to the thiol family. Here are some fascinating facts about this compound:

Structure and Stability: The presence of both a methoxy group and a thiol group makes this compound unique. The ^–OCH₃ (methoxy) group is known for enhancing the stability of the aromatic ring.
Reactivity: As a thiol, 4-methoxybenzenethiol exhibits typical thiol properties, such as the ability to form disulfide bonds and participate in nucleophilic substitutions.
Applications in Chemistry: This compound is often used in the synthesis of more complex molecules and can serve as a valuable building block in organic synthesis.
Flavor and Fragrance: Due to its aromatic nature, 4-methoxybenzenethiol may be used in the fragrance industry for its pleasant scent, which resembles that of certain flowers.
Biological Relevance: Thiols are crucial in biological systems, often involved in redox reactions. The methoxy group can influence the biological activity of 4-methoxybenzenethiol, making it of interest in medicinal chemistry.

Overall, 4-methoxybenzenethiol is more than just a simple compound; it encapsulates a variety of potential applications and characteristics important for both academic research and practical use.

Synonyms

4-Methoxybenzenethiol

4-Methoxythiophenol

Benzenethiol, 4-methoxy-

p-Methoxybenzenethiol

4-methoxybenzene-1-thiol

BENZENETHIOL, p-METHOXY-

4-Mercaptoanisole

p-methoxythiophenol

para-Methoxybenzenethiol

NSC 100727

EINECS 211-799-2

4-methoxyphenylthiol

p-Methoxy thiophenol

BRN 1446910

68N68LMU0G

P-MERCAPTOANISOLE

P-METHOXYPHENYLTHIOL

NSC-100727

UNII-68N68LMU0G

METHOXYBENZENETHIOL, 4-

P-METHOXYPHENYL MERCAPTAN

4-METHOXYPHENYL MERCAPTAN

NIFAOMSJMGEFTQ-UHFFFAOYSA-

DTXSID60219873

Benzenethiol, 4-methoxy-(9CI)

DTXCID10142364

211-799-2

4-06-00-05790 (beilstein handbook reference)

inchi=1/c7h8os/c1-8-6-2-4-7(9)5-3-6/h2-5,9h,1h3

nifaomsjmgeftq-uhfffaoysa-n

696-63-9

4-Methoxy-benzenethiol

4-Methoxy thiophenol

4-mercaptoanisol

4methoxythiophenol

4methoxybenzenethiol

4-methoxybenzenthiol

4-methoxy-thiophenol

MFCD00004849

NSC100727

4-methoxylbenzenethiol

4-methoxy benzenethiol

4-methoxybenzene thiol

4-methoxy-benzene thiol

4-(methyloxy)benzenethiol

WLN: SHR DO1

4-Methoxythiophenol, 97%

SCHEMBL50514

CHEMBL119636

CS-D1129

STR00751

BBL027485

STL374080

AKOS005203301

AC-7112

FM36232

DB-055318

M1333

NS00015223

4-Methoxythiophenol, purum, >=98.0% (GC)

EN300-11815

D78094

F0001-1809

QU5