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4-Methyl-3-nitroaniline

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Identification
Molecular formula
C7H8N2O2
CAS number
119-32-4
IUPAC name
4-methyl-3-nitro-aniline
State
State

The compound is typically found as a solid at room temperature and is characterized by its crystalline form.

Melting point (Celsius)
149.00
Melting point (Kelvin)
422.15
Boiling point (Celsius)
350.20
Boiling point (Kelvin)
623.40
General information
Molecular weight
152.16g/mol
Molar mass
152.1570g/mol
Density
1.2780g/cm3
Appearence

The compound appears as a yellow to dark yellow crystalline solid. It may sometimes form needle-like crystals.

Comment on solubility

Solubility of 4-methyl-3-nitro-aniline

4-methyl-3-nitro-aniline, a substituted aniline derivative, exhibits interesting solubility characteristics that can greatly influence its applications in various fields. The solubility of this compound is primarily determined by:

  • Polarity: The presence of both an amino group (-NH2) and a nitro group (-NO2) contributes to its polar nature.
  • Hydrogen Bonding: The amino group can form hydrogen bonds with solvents, enhancing its solubility in polar solvents like water.
  • Organic Solvents: 4-methyl-3-nitro-aniline is also soluble in various organic solvents, including ethanol and acetone, due to its ability to interact with their molecular structures.
  • pH Dependence: The solubility can be affected by the pH of the solution; at higher pH levels, the amino group can become deprotonated, which may alter solubility properties.

It is noteworthy that as the compound has a non-polar methyl group, it tends to be less soluble in non-polar solvents compared to polar ones. In summary, 4-methyl-3-nitro-aniline is characterized by:

  • Good solubility in water (polar solvents),
  • Increased solubility in alcohols and various organic solvents,
  • Higher solubility in basic conditions due to deprotonation of the amino group.

With its distinctive solubility profile, the compound can be crucial in applications such as drug formulation and dye production, where understanding solubility is essential for effective use.

Interesting facts

Interesting Facts about 4-Methyl-3-nitro-aniline

4-Methyl-3-nitro-aniline, often referred to in scientific circles due to its various applications and unique properties, is a fascinating compound that has garnered attention in both academia and industry. Here are some intriguing points about this chemical:

  • Chemical Structure: The presence of both amino and nitro functional groups in this compound plays a pivotal role in determining its reactivity, making it a valuable building block in organic synthesis.
  • Applications in Dyes: One of the primary uses of 4-methyl-3-nitro-aniline is in the production of azo dyes. These dyes are widely used in the textile industry for their vibrant colors and stability.
  • Pharmaceutical Relevance: Due to its structural similarities to other biologically active compounds, 4-methyl-3-nitro-aniline has potential applications in medicinal chemistry and may serve as a lead compound for developing new pharmaceuticals.
  • Environmental Considerations: While this compound has useful applications, it is also important to consider its environmental impacts. The manufacturing and degradation of nitroanilines can pose risks to aquatic life and ecosystems, prompting the need for responsible handling.
  • Regulatory Status: Researchers must navigate various regulatory frameworks when working with 4-methyl-3-nitro-aniline, as substances containing nitro groups are often subject to rigorous evaluations due to their potential toxicity.

In summary, 4-methyl-3-nitro-aniline serves as an excellent example of how a simple organic compound can have diverse and important applications, while also highlighting the need for careful consideration of environmental health and safety.

Synonyms
4-Methyl-3-nitroaniline
119-32-4
4-Amino-2-nitrotoluene
3-Nitro-p-toluidine
3-Nitro-4-toluidine
3-Nitro-4-methylaniline
m-Nitro-p-toluidine
2-Nitro-4-aminotoluene
Benzenamine, 4-methyl-3-nitro-
5-Nitro-4-toluidine
p-Toluidine, 3-nitro-
GL-Amin [Czech]
3-Nitro-4-toluidin
Gl-amin
3-Nitro-4-toluidin [Czech]
CCRIS 3003
NSC 7731
EINECS 204-314-0
BRN 0638984
4-methyl-3-nitro-aniline
UNII-SM8UZ1Q81F
4-methyl-3-nitrophenylamine
SM8UZ1Q81F
DTXSID7025633
NSC-7731
MFCD00007910
4-methyl-3-nitrobenzenamine
DTXCID805633
CHEBI:81670
1-Amino-3-nitro-4-methylbenzene
4-12-00-01997 (Beilstein Handbook Reference)
aniline, 4-methyl-3-nitro-
4-methyl-3-nitro aniline
nitrotoluidine
LS-614
3-Nitro-4-methylanilin
4Am2NT
MONONITROTOLUIDINES
3-nitro-4-methyl-aniline
WLN: ZR D1 CNW
4-methyl-3-nitro-phenylamine
NITROTOLUIDINES (MONO)
SCHEMBL100616
(4-methyl-3-nitrophenyl)amine
CHEMBL1350617
SCHEMBL17347354
4-Methyl-3-nitroaniline, 97%
NSC7731
4-Amino-1-methyl-2-nitrobenzene
(4-methyl-3-nitro-phenyl)-amine
BCP32906
Tox21_200103
3-NITRO-4-AMINOMETHYLBENZENE
STK387113
AKOS000119120
AC-1739
PS-5957
NCGC00091307-01
NCGC00091307-02
NCGC00091307-03
NCGC00257657-01
BP-20389
CAS-119-32-4
DB-041463
N0278
NS00008727
EN300-19073
C18320
AB00514384-03
A804255
AC-907/25014173
Q27155550
F8880-0867
Z104472590
3-Nitro-p-toluidine;3-Nitro-4-methylaniline;4-Amino-2-nitrotoluene
3-nitro-4-aminomethylbenzene;4-Amino-2-nitrotoluene~3-Nitro-p-toluidine