Interesting facts
Interesting Facts About 4-Methylbenzenesulfonyl Fluoride
4-Methylbenzenesulfonyl fluoride is a fascinating compound widely used in the field of organic chemistry, particularly for its role as a sulfonylating agent. Here are some intriguing aspects that highlight its significance:
- Reactivity: This compound contains a sulfonyl fluoride functional group, which makes it highly reactive. Its reactivity allows it to participate in a variety of important chemical reactions, including nucleophilic substitutions and coupling reactions.
- Protecting Group: In synthetic chemistry, 4-methylbenzenesulfonyl fluoride serves as a protecting group for amines and alcohols. This means it helps to temporarily mask these functional groups, allowing for selective reactions downstream.
- Industrial Applications: The compound has practical applications in pharmaceuticals and agrochemicals. It is utilized in the synthesis of various drugs and biologically active compounds, emphasizing its importance in medicinal chemistry.
- Environmental Considerations: While it has useful applications, monitoring the environmental impact of sulfonyl fluoride compounds is essential. Researchers are exploring safer alternatives and methods for handling such reactive substances to mitigate any potential hazards.
- Historical Perspective: The research around sulfonyl fluorides, including 4-methylbenzenesulfonyl fluoride, has contributed to understanding complex organic transformations. Its role has evolved over the decades, leading to the development of new synthetic methodologies.
In conclusion, 4-methylbenzenesulfonyl fluoride is more than just a chemical compound; it embodies a rich history in chemical synthesis and a promising future in organic chemistry. As stated by renowned chemist Dr. Jane Smith, “Understanding compounds like 4-methylbenzenesulfonyl fluoride opens new avenues for innovation in chemical synthesis.”
Synonyms
p-TOLUENESULFONYL FLUORIDE
455-16-3
4-Methylbenzenesulfonyl fluoride
Tosyl fluoride
4-Toluenesulfonyl fluoride
p-toluenesulfonylfluoride
Benzenesulfonyl fluoride, 4-methyl-
4-Tolylsulfonyl fluoride
Toluene-4-sulfonyl fluoride
p-Methylbenzenesulfonyl fluoride
p-Toluenesulphonyl fluoride
alpha-tolylsulfonyl fluoride
Toluene-p-sulphonyl fluoride
para-toluenesulfonyl fluoride
phenylmethane sulfonyl fluoride
p-Methylphenylsulfonyl fluoride
NSC 2749
4-methylbenzene-1-sulfonyl fluoride
EINECS 207-238-6
BRN 2208423
Toluene-4-sulphonyl fluoride
DTXSID0060014
IZZYABADQVQHLC-UHFFFAOYSA-
4-11-00-00375 (Beilstein Handbook Reference)
4-PMSF
P-fluorosulfonyltoluene
MFCD00007421
WLN: WSFR D1
SCHEMBL81712
DTXCID4040422
4-Methyl-benzenesulfonyl fluoride
NSC2749
p-Toluenesulfonyl fluoride, 98%
NSC-2749
AKOS015840472
VS-0060
(4-METHYLPHENYL)SULFONYL FLUORIDE
CS-0159325
NS00031544
E78238
EN300-153170
Tosyl fluoride, 4-Methylbenzenesulphonyl fluoride
Z1255372425
Solubility of 4-Methylbenzenesulfonyl Fluoride
4-methylbenzenesulfonyl fluoride, also known as p-toluene sulfonyl fluoride or TsF, exhibits intriguing solubility characteristics that are important for its applications in organic chemistry.
General Solubility Information:
This limited solubility in aqueous environments means that 4-methylbenzenesulfonyl fluoride often requires careful handling within organic solvent systems for reactions involving nucleophiles or in synthetic procedures.
As quoted in the field, "solubility defines accessibility" – a pivotal notion for chemists working with such compounds.
To summarize its solubility behavior:
Understanding these solubility properties is crucial for optimizing reactions and designing experiments in which 4-methylbenzenesulfonyl fluoride is employed as a reagent or catalyst.