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4-Methylumbelliferone

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Identification
Molecular formula
C10H8O2
CAS number
90-33-5
IUPAC name
4-methylchromen-2-one
State
State

At room temperature, 4-Methylumbelliferone is typically found in a solid state, specifically as a crystalline powder.

Melting point (Celsius)
199.00
Melting point (Kelvin)
472.15
Boiling point (Celsius)
282.20
Boiling point (Kelvin)
555.35
General information
Molecular weight
176.17g/mol
Molar mass
176.1730g/mol
Density
1.2375g/cm3
Appearence

4-Methylumbelliferone appears as a white crystalline powder. It can exhibit fluorescence, emitting a bright blue light under ultraviolet light, which is a property used in various biochemical assays.

Comment on solubility

Solubility of 4-methylchromen-2-one

4-methylchromen-2-one, also known as chromone, exhibits some interesting solubility characteristics that are worthy of discussion. Its solubility can be influenced by various factors, including:

  • Polarity: The presence of the methyl group in its structure affects the overall polarity of the compound, which can influence its solubility in different solvents.
  • Solvent Type: 4-methylchromen-2-one is generally more soluble in organic solvents such as ethanol and acetone compared to water, which indicates its preference for non-polar environments.
  • Temperature effects: Increased temperature often enhances the solubility of solids in liquids, and this compound is no exception — elevated temperatures can lead to a higher solubility in suitable solvents.

In summary, the solubility of 4-methylchromen-2-one is largely determined by its interaction with solvent molecules. The combination of factors such as polarity and temperature play significant roles. Understanding these factors allows chemists to predict how this compound will behave in different chemical environments, stating that “solubility is not a simple property, but a complex interaction” that varies between solvents.

Interesting facts

Exploring 4-Methylchromen-2-one

4-Methylchromen-2-one, an intriguing compound also known as 7-Methylcoumarin, falls under the class of coumarins, which are widely recognized for their diverse biological activities and roles in natural products.

Key Characteristics of 4-Methylchromen-2-one:

  • Natural Source: This compound is often derived from various plants, particularly those in the Apiaceae family, and is also found in many essential oils.
  • Biological Importance: It plays a significant role in medicinal chemistry, with research indicating potential anti-inflammatory, anti-cancer, and anti-bacterial properties.
  • Fluorescent Properties: 4-Methylchromen-2-one exhibits fluorescence, making it useful in various applications, including as a fluorescent probe in biological systems.
  • Flavor and Fragrance: This compound contributes to the aroma and flavor of many food items and is used in the cosmetic industry due to its pleasant scent.

Applications in Research:

4-Methylchromen-2-one is not only valuable in the food and fragrance industries but is also a subject of scientific investigation. Researchers are keen on studying its reactivity and potential usage in novel therapies. As noted by chemists in the field, "The unique structure of coumarins presents a treasure trove for drug discovery, particularly in developing new anti-cancer agents."

Tips for Chemistry Enthusiasts:

  • When studying compounds like 4-Methylchromen-2-one, pay attention to their structure-activity relationships (SAR) to appreciate how molecular modifications can enhance biological activity.
  • Experiment with synthesizing coumarins in the laboratory to gain hands-on experience with aromatic organic compounds.

In summary, 4-Methylchromen-2-one is a remarkable compound that exemplifies the intersection of nature and chemistry, showcasing potential that is still being explored by scientists around the world.

Synonyms
4-Methylcoumarin
4-methylchromen-2-one
COUMARIN, 4-METHYL-
2H-1-Benzopyran-2-one, 4-methyl-
4-Methyl-2H-1-benzopyran-2-one
EINECS 210-141-1
UNII-2YZ8R79U9H
NSC 20100
BRN 0121648
2YZ8R79U9H
NSC-20100
METHYLCOUMARIN, 4-
DTXSID00209516
5-17-10-00166 (Beilstein Handbook Reference)
DTXCID50132007
2H-1-Benzopyran-2-one, 4-methyl-(9CI)
210-141-1
psgqccsgkgjlrl-uhfffaoysa-n
607-71-6
4-Methyl-2H-chromen-2-one
4-Methylcumarin
4-Methyl-chromen-2-one
NSC20100
4-METHYLUMBELLIFERYL
MFCD00185474
2H-1-Benzopyran-2-one, 4-methyl- (9CI)
SCHEMBL66891
CHEMBL12279
WLN: T66 BOVJ E1
4-Methyl-2H-chromen-2-one #
HMS1693J19
BCP28723
MSK164094
AKOS000277307
DB08785
AS-17408
PD004533
1ST164094
M3041
NS00014399
Q27097965