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4-Methylpyridine

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Identification
Molecular formula
C6H7N
CAS number
108-89-4
IUPAC name
4-methylpyridine
State
State

At room temperature, 4-Methylpyridine is a liquid. It is practically insoluble in water but soluble in organic solvents such as ethanol and ether.

Melting point (Celsius)
-2.70
Melting point (Kelvin)
270.45
Boiling point (Celsius)
145.30
Boiling point (Kelvin)
418.45
General information
Molecular weight
93.13g/mol
Molar mass
93.1310g/mol
Density
0.9647g/cm3
Appearence

4-Methylpyridine is a colorless liquid with a characteristic pyridine odor. It is often used in the synthesis of various chemicals and has a distinctive smell that is somewhat unpleasant.

Comment on solubility

Solubility of 4-Methylpyridine

4-Methylpyridine, known for its characteristic pyridine ring structure, exhibits notable solubility properties that are important for various applications in chemistry. Here’s an overview of its solubility:

  • Solvent Compatibility: 4-methylpyridine is soluble in water to a certain extent, but it displays a much higher solubility in organic solvents such as:
    • Alcohols (e.g., methanol, ethanol)
    • Aromatic hydrocarbons (e.g., toluene, benzene)
    • Dimethyl sulfoxide (DMSO)
  • Temperature Influence: The solubility of 4-methylpyridine typically increases with temperature, a common behavior observed in many organic compounds. This makes it versatile for reactions where temperature control is essential.
  • pH Dependence: Being a nitrogen-containing heterocycle, its solubility can also be influenced by the pH of the solution, particularly in aqueous environments where it can form ionic species under certain conditions.

In summary, the solubility characteristics of 4-methylpyridine underline its utility in both synthetic and analytical chemistry, making it a compound of interest for researchers.

Interesting facts

Interesting Facts About 4-Methylpyridine

4-Methylpyridine, also known as picoline, is a fascinating organic compound that belongs to the class of heterocyclic aromatic compounds. With its unique structural features, it has garnered attention in various fields of chemistry and industry.

Chemical Structure and Properties

  • Structural Characteristics: 4-Methylpyridine contains a pyridine ring with a methyl group attached at the fourth position, which influences its chemical reactivity and properties.
  • Basic Properties: Due to the presence of the nitrogen atom in the ring, this compound exhibits basic characteristics, making it an important building block in organic synthesis.

Applications in Industry

  • Solvent: It is commonly used as a solvent in various chemical reactions due to its ability to dissolve both polar and nonpolar compounds.
  • Intermediate in Synthesis: 4-Methylpyridine serves as an intermediate in the production of pharmaceuticals, agrochemicals, and fragrances.
  • Research Applications: This compound is also significant in research for the study of nitrogen-containing heterocycles and their reactions.

Environmental and Safety Considerations

While 4-Methylpyridine is vital in many applications, it is essential to handle this compound with care due to its potential health hazards. Researchers and industrial workers should be aware of:

  • Toxicity: It can be irritating to the skin, eyes, and respiratory tract, necessitating the use of protective equipment.
  • Environmental Impact: As with many organic compounds, there is a need for proper waste disposal and management to minimize ecological risks.

In summary, 4-Methylpyridine stands out as an interesting compound with significant roles in research and industry. Its versatile applications, combined with its unique properties, continue to make it a subject of study and exploration among chemists.

Synonyms
4-METHYLPYRIDINE
4-Picoline
108-89-4
Pyridine, 4-methyl-
gamma-Picoline
p-Picoline
p-Methylpyridine
4-methyl pyridine
4-methyl-pyridine
gamma-Methylpyridine
Ba 35846
4-methylpyridinium
4-Mepy
NSC 18252
PICOLINE, GAMMA
CCRIS 1723
HSDB 5386
UNII-TJD6V9SSO7
TJD6V9SSO7
.gamma.-Picoline
EINECS 203-626-4
4-METHYL-D1-PYRIDINE
DTXSID4021892
CHEBI:32547
.gamma.-Methylpyridine
AI3-24111
NSC-18252
DTXCID201892
69046-49-7
BA-35846
CAS-108-89-4
gamma-picolin
4-pi-coline
para-Methylpyridine
4-Methylpyridine, 98%
4-Methylpyridine, 99%
NCIOpen2_007706
WLN: T6NJ D1
CHEMBL15544
.GAMMA.-PICOLINE [MI]
4-METHYLPYRIDINE [HSDB]
NSC18252
Tox21_201400
Tox21_302961
BBL011459
MFCD00006440
STL146571
AKOS000119191
RTE3_000025
NCGC00249042-01
NCGC00256613-01
NCGC00258951-01
4-Picoline, analytical reference material
PD182276
4-METHYL-PYRIDINE (GAMMA-PICOLINE)
DB-031403
DB-185117
DB-358358
p-Picoline [UN2313] [Flammable liquid]
A2139
NS00015293
P0417
EN300-19109
PK04_181300
A801938
Q2189778
F0001-0182
InChI=1/C6H7N/c1-6-2-4-7-5-3-6/h2-5H,1H
203-626-4
92075-35-9