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4-Methylquinoline

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Identification
Molecular formula
C10H9N
CAS number
91-63-4
IUPAC name
4-methylquinoline
State
State

At room temperature, 4-Methylquinoline is typically in a liquid state.

Melting point (Celsius)
8.30
Melting point (Kelvin)
281.45
Boiling point (Celsius)
261.00
Boiling point (Kelvin)
534.15
General information
Molecular weight
143.19g/mol
Molar mass
143.1860g/mol
Density
1.0846g/cm3
Appearence

4-Methylquinoline is a yellow liquid with an amine-like odor.

Comment on solubility

Solubility of 4-methylquinoline

4-methylquinoline, a nitrogen-containing heterocyclic compound, exhibits unique solubility characteristics that are of interest in various chemical and medicinal contexts. Here are several key points regarding its solubility:

  • Solvent Compatibility: 4-methylquinoline is generally soluble in organic solvents, such as ethanol, methanol, and chloroform. This solubility can be attributed to the molecule's hydrophobic aromatic structure which interacts favorably with non-polar solvents.
  • Water Solubility: In contrast, 4-methylquinoline has limited solubility in water. Due to its hydrophobic nature, it does not readily dissolve in aqueous solutions.
  • Influence of Substituents: The presence of the methyl group on the quinoline ring influences its solubility. Increasing the number of methyl groups or other polar substituents can enhance aqueous solubility by providing additional polar interactions.
  • Temperature and Concentration Effects: Like many organic compounds, the solubility of 4-methylquinoline can change with temperature. Generally, higher temperatures can increase solubility in solvents, while factors like concentration and purity of the solution also play significant roles.

In summary, while 4-methylquinoline is soluble in various organic solvents, its low solubility in water limits its applications in aqueous environments. The structural attributes and substituents of this compound are crucial in determining its solubility behavior, making it a fascinating subject for further investigation.

Interesting facts

Interesting Facts About 4-Methylquinoline

4-Methylquinoline is a fascinating compound, known for its diverse applications and intriguing properties. As a derivative of quinoline, it features a nitrogen atom within its aromatic ring structure, enhancing its reactivity and functionality. Here are some notable insights:

  • History: 4-Methylquinoline was first synthesized in the early 20th century, and it has since attracted attention for its unique chemical stability and ability to form a variety of derivatives.
  • Applications: This compound plays a significant role in the following areas:
    • As a building block in the synthesis of pharmaceuticals and agrochemicals.
    • In the development of fluorescent dyes, contributing to analytical chemistry and visualization techniques.
    • In organic chemistry research, where it serves as a reactant in various chemical reactions.
  • Biological Activity: Research has shown that 4-Methylquinoline exhibits antibacterial, antifungal, and even antimalarial properties, making it a compound of interest in medicinal chemistry.
  • Fluorescence: This compound is known for its fluorescence under UV light, making it useful in various detection methods and enhancing the contrast in certain biological imaging techniques.
  • Environmental Impact: While 4-Methylquinoline has useful applications, awareness of its environmental impact is vital. Its persistence and potential toxicity require careful management in industrial settings.

In summary, 4-Methylquinoline is more than just a chemical compound; it's a versatile building block in modern chemistry with applications ranging from pharmaceuticals to environmental science. Its structural characteristics and biological activities make it both a subject of study and a tool for scientific advancement.

Synonyms
Lepidine
4-METHYLQUINOLINE
491-35-0
Quinoline, 4-methyl-
Cincholepidine
Lepidin
4-Lepidine
gamma-Methylquinoline
CCRIS 2894
HSDB 7153
NSC 3412
AI3-24277
EINECS 207-734-2
BRN 0110926
DTXSID7047067
CHEBI:48983
LEPIDINE [MI]
NSC-3412
116169T3O8
DTXCID5027067
5-20-07-00389 (Beilstein Handbook Reference)
pMethylquinoline
4Lepidine
4-lepidin
gammaMethylquinoline
Quinoline, 4methyl
207-734-2
inchi=1/c10h9n/c1-8-6-7-11-10-5-3-2-4-9(8)10/h2-7h,1h
p-Methylquinoline
4-methyl-quinoline
MFCD00006784
.gamma.-Methylquinoline
4-methyl quinoline
Lepidine (4-Methylquinoline)
UNII-116169T3O8
Lepidine, 99%
methyl-4 isoquinoleine
CHEMBL9734
SCHEMBL31559
4-Methylquinoline, >=99%
NSC3412
BCP27150
STR06140
Tox21_301829
AKOS000119150
FM35012
PS-3771
NCGC00184238-01
NCGC00184238-02
NCGC00184238-03
NCGC00184238-04
NCGC00184238-05
NCGC00184238-06
NCGC00184238-07
NCGC00184238-08
NCGC00184238-09
NCGC00184238-10
NCGC00256086-01
CAS-491-35-0
DB-013319
L0024
NS00012990
EN300-19081
A22510
H10212
Q6527408
F0001-1281
Z104472668