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4-Nitroindazole

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Identification
Molecular formula
C7H5N3O2
CAS number
78919-13-8
IUPAC name
4-nitro-1H-indazole
State
State

This compound is typically found as a solid at room temperature.

Melting point (Celsius)
162.00
Melting point (Kelvin)
435.15
Boiling point (Celsius)
435.50
Boiling point (Kelvin)
708.65
General information
Molecular weight
177.14g/mol
Molar mass
177.1460g/mol
Density
1.4540g/cm3
Appearence

4-Nitro-1H-indazole typically appears as a yellowish to beige crystalline solid. The compound is light-sensitive and should be stored properly to maintain its stability.

Comment on solubility

Solubility of 4-nitro-1H-indazole

4-nitro-1H-indazole is a compound that exhibits interesting solubility characteristics. Understanding its solubility behavior is crucial for various applications, especially in pharmaceutical and chemical research. Here are some key points regarding its solubility:

  • Solvent Interaction: 4-nitro-1H-indazole is generally more soluble in polar organic solvents, such as ethanol and methanol, due to the presence of its nitro group which can engage in hydrogen bonding.
  • Water Solubility: This compound has limited solubility in water, which can be attributed to its hydrophobic indazole ring structure that does not favor interactions with polar water molecules.
  • Crystallization: The compound can be effectively crystallized from suitable organic solvents, allowing for its purification and characterization.

In terms of practical use, when preparing solutions of 4-nitro-1H-indazole, it is essential to consider the solvent choice to achieve optimal concentrations. A well-known observation is that "solubility enhances the potential for biological activity." Therefore, understanding and manipulating the solubility of such compounds can lead to significant implications in drug formulation and design.

Interesting facts

Interesting Facts about 4-nitro-1H-indazole

The compound 4-nitro-1H-indazole belongs to the indazole family, a class of aromatic heterocycles known for their versatile chemical properties and biological activities. This compound, characterized by the presence of a nitro group at the 4-position, offers a unique perspective in the field of medicinal chemistry.

Here are some key points of interest regarding 4-nitro-1H-indazole:

  • Pharmacological Potential: Several studies have highlighted the potential of 4-nitro-1H-indazole derivatives as promising candidates in drug discovery. They have been evaluated for activities such as anti-inflammatory, anti-cancer, and anti-microbial properties.
  • Structural Features: The presence of the indazole structure, a fusion of a pyrazole and a benzene ring, contributes to large surface area and unique electronic properties, making it an appealing scaffold for the development of new compounds.
  • Chemical Reactivity: The nitro group is known to enhance the electrophilicity of aromatic compounds, which can lead to increased reactivity towards nucleophiles, thus facilitating various chemical transformations.
  • Research Applications: 4-nitro-1H-indazole has gained attention in the realm of material science as well, where it is utilized in the synthesis of functional materials due to its electron-deficient character.

In summary, 4-nitro-1H-indazole serves as a fascinating subject in both academic and industrial research, with its dual applicability in medicinal chemistry and material science drawing considerable interest from scientists worldwide. As research continues, the potential of this compound and its derivatives promises to unveil valuable insights into new therapeutic avenues.

Synonyms
4-Nitro-1H-indazole
2942-40-7
4-Nitroindazole
1H-Indazole, 4-nitro-
INDAZOLE, 4-NITRO-
NSC 96892
BRN 0008161
99ML8W90BD
NSC-96892
DTXSID70183637
5-23-06-00179 (Beilstein Handbook Reference)
1H-Indazole, 4-nitro-(8CI)
DTXCID10106128
1H-Indazole, 4-nitro-(8CI)(9CI)
800-019-1
inchi=1/c7h5n3o2/c11-10(12)7-3-1-2-6-5(7)4-8-9-6/h1-4h,(h,8,9
MFCD00022784
MLS002703355
CHEMBL393456
4nitroindazole
4-nitro indazole
NSC96892
4-nitro-1H-indazol
4-nitro 1H-indazole
4-nitro-1 H-indazole
4-Nitro-1H-indazole #
NCIOpen2_001613
UNII-99ML8W90BD
WLN: T56 BMNJ FNW
SCHEMBL166086
BCP26691
CS-D0097
BDBM50304143
AKOS005070452
AKOS015966074
AC-7079
BCP9000167
PB32089
SMR001570077
SY003894
4P-009
EN300-120212
A819913
Z381673564