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4-nitro-N-thiazol-2-ylbenzenesulfonamide

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Identification
Molecular formula
C9H7N3O4S2
CAS number
38006-08-5
IUPAC name
4-nitro-N-thiazol-2-yl-benzenesulfonamide
State
State

At room temperature, 4-nitro-N-thiazol-2-ylbenzenesulfonamide exists as a solid. It is stable under normal conditions, making it suitable for various chemical applications where solid-state materials are required.

Melting point (Celsius)
182.00
Melting point (Kelvin)
455.00
Boiling point (Celsius)
358.90
Boiling point (Kelvin)
632.00
General information
Molecular weight
296.32g/mol
Molar mass
296.3230g/mol
Density
1.5460g/cm3
Appearence

4-Nitro-N-thiazol-2-ylbenzenesulfonamide is typically a yellow to orange crystalline solid. Its fine powder or crystal form gives it a distinct vibrant coloration that is noticeable.

Comment on solubility

Solubility of 4-nitro-N-thiazol-2-yl-benzenesulfonamide

The solubility of 4-nitro-N-thiazol-2-yl-benzenesulfonamide varies significantly depending on the solvent used. This compound exhibits some interesting characteristics:

  • Water Solubility: It tends to have low solubility in water, which is typical for many sulfonamide derivatives due to their relatively high molecular weight and structural complexity.
  • Solvent Interactions: While its water solubility is limited, it can be more soluble in organic solvents such as:
    • DMSO (Dimethyl sulfoxide)
    • DMF (Dimethylformamide)
    • Acetone
  • Temperature Effects: Like many chemical compounds, the solubility of 4-nitro-N-thiazol-2-yl-benzenesulfonamide is generally enhanced with an increase in temperature, making it easier to dissolve in suitable solvents.

In summary, while 4-nitro-N-thiazol-2-yl-benzenesulfonamide may not be highly soluble in aqueous environments, its solubility profile is quite favorable in organic solvents, showcasing the diverse interactions it can have with various substances. As a researcher, one should always consider the implications of solubility on the compound's applications and reactivity.

Interesting facts

Interesting Facts about 4-Nitro-N-thiazol-2-yl-benzenesulfonamide

4-Nitro-N-thiazol-2-yl-benzenesulfonamide is a fascinating compound that has garnered attention in the field of medicinal chemistry. Here are some intriguing aspects of this versatile compound:

  • Therapeutic Applications: This compound has been studied for its potential use in pharmaceuticals, particularly as an antibacterial agent. The presence of the thiazole ring may enhance its biological activity.
  • Mechanism of Action: It is believed that the sulfonamide group plays a critical role in its interaction with bacterial enzymes, disrupting folic acid synthesis and inhibiting bacterial growth.
  • Research Significance: Scientists are continuously exploring derivatives of this sulfonamide to improve efficacy and reduce side effects. This opens up exciting possibilities for the development of new drugs.
  • Structural Diversity: The unique combination of thiazole and sulfonamide functionalities in this compound makes it a prime candidate for structure-activity relationship (SAR) studies, aiming to optimize its performance.
  • Environmental Impact: Investigations into the environmental stability and degradation pathways of compounds like 4-nitro-N-thiazol-2-yl-benzenesulfonamide are essential to assess their ecological footprint.

As the field of medicinal chemistry evolves, the study of compounds like 4-nitro-N-thiazol-2-yl-benzenesulfonamide will undeniably contribute to the development of novel therapeutic agents. The compound serves as a reminder of the intricate relationship between chemical structure and biological function, underlining the importance of thorough research in uncovering new medical applications.

Synonyms
Nitrosulfathiazole
473-42-7
para-Nitrosulfathiazole
Nitrosulfatiazol
Nisulfazol
Nitrosulfathiazol
Sulfanitrothiazole
Nitrosulfathiazolum
Nitrosulfathiazole [INN]
UNII-FO9CU4TX7J
FO9CU4TX7J
Para-nitrosulfathiazole [NF]
2-(p-Nitrophenylsulfonamido)thiazole
p-Nitro-N-2-thiazolylbenzenesulfonamide
4-Nitro-N-(2-thiazolyl)benzolsulfonamid
DTXSID10197091
Benzenesulfonamide, 4-nitro-N-2-thiazolyl-
Benzenesulfonamide, p-nitro-N-2-thiazolyl-
DTXCID20119582
p-Nitrosulfathiazole
4-nitro-N-(1,3-thiazol-2-yl)benzenesulfonamide
Nisulfazole
SR-01000945161
Oprea1_119305
Oprea1_516228
MLS006011408
SCHEMBL338503
CHEMBL593262
STL260521
AKOS000668688
SMR002530487
NS00120688
SR-01000945161-1
SR-01000945161-2
Q27278106
4-NITRO-N-(1,3-THIAZOL-2-YL)-1-BENZENESULFONAMIDE