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4-Nitrobenzamide

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Identification
Molecular formula
C7H6N2O3
CAS number
619-80-7
IUPAC name
4-nitrobenzamide
State
State

At room temperature, 4-Nitrobenzamide is a solid.

Melting point (Celsius)
211.00
Melting point (Kelvin)
484.00
Boiling point (Celsius)
298.00
Boiling point (Kelvin)
571.00
General information
Molecular weight
166.14g/mol
Molar mass
166.1420g/mol
Density
1.4360g/cm3
Appearence

4-Nitrobenzamide appears as a yellow crystalline solid.

Comment on solubility

Solubility of 4-nitrobenzamide

4-nitrobenzamide, with the chemical formula C7H6N2O3, exhibits notable solubility characteristics that are important to consider in various applications.

The solubility of 4-nitrobenzamide can be described as follows:

  • Polar Solvents: It shows some solubility in polar solvents such as water due to its amide functional group, which allows for hydrogen bonding.
  • Organic Solvents: This compound is more readily soluble in many organic solvents like ethanol, methanol, and acetone, where it can interact more favorably due to similar polarities.
  • Temperature Dependence: Solubility tends to increase with temperature, which is a common trait among many organic compounds.

In practical terms, understanding the solubility of 4-nitrobenzamide is crucial for researchers and chemists when planning syntheses or formulations. Its varied solubility can influence reactions, facilitate purification processes, and determine bioavailability in pharmaceutical applications.

In summary, recognizing the solubility properties of 4-nitrobenzamide aids in its effective use in both research and industry.

Interesting facts

Interesting Facts About 4-Nitrobenzamide

4-Nitrobenzamide is a fascinating compound with diverse applications and unique properties that make it a subject of interest in both organic chemistry and pharmaceuticals.

Key Applications:

  • Pharmaceuticals: This compound acts as a versatile intermediate in the synthesis of various pharmaceutical agents, particularly those aimed at treating bacterial infections.
  • Research Tool: Known for its role in studying enzyme reactions, 4-nitrobenzamide has been used in biochemical assays to explore enzyme inhibitors and other related studies.
  • Material Science: Its characteristics are useful in the development of polymers and other materials where specific functional groups are necessary.

Properties and Reactions:

4-Nitrobenzamide has distinctive reactivity patterns owing to its functional groups. Noteworthy reactions include:

  • Nucleophilic Substitution: The nitro group enhances the electrophilic character of the carbonyl carbon, making it susceptible to nucleophiles.
  • Aromatic Substitution: This compound undergoes electrophilic aromatic substitution reactions, which are essential in creating more complex aromatic systems.

Fun Fact:

As a member of the nitro compounds family, it embodies the intriguing balance between stability and reactivity. This balance makes it a strong candidate for experimental studies, where scientists often describe compounds like 4-nitrobenzamide as “the bridge between reactivity and functionality.”

Cautionary Note:

When handling 4-nitrobenzamide, it’s important to follow appropriate safety protocols due to its nitro group, which can impart toxicological concerns if not managed correctly.

In conclusion, 4-nitrobenzamide is not only a valuable compound in synthetic chemistry but also serves as a prime example of the intricate relationships between structure and reactivity in organic compounds.

Synonyms
4-NITROBENZAMIDE
p-Nitrobenzamide
Benzamide, 4-nitro-
4-nitro-benzamide
NSC 2902
EINECS 210-613-7
DTXSID8022086
AI3-01346
DTXCID002086
4-NITROBENZOIC ACID, AMIDE
210-613-7
zeswuebprpgmtp-uhfffaoysa-n
619-80-7
Benzamide, p-nitro-
MFCD00007994
NSC-2902
p-Nitrobenzamide, 98%
4-Nitrobenzamide, 98%
NITROBENZAMIDE, P-
SCHEMBL260727
683NB4HAX7
benzene, 1-carbamoyl-4-nitro-
CHEMBL1483601
SCHEMBL10048528
NSC2902
Tox21_200343
BBL003846
STK395626
AKOS003261392
FN02090
MS-9497
NCGC00090909-01
NCGC00090909-02
NCGC00257897-01
CAS-619-80-7
NCI60_002383
DB-030268
N0323
NS00034875
EN300-15613
AE-641/00419025
Z33546474