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p-Nitrophenyl acetate

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Identification
Molecular formula
C8H7NO4
CAS number
830-03-5
IUPAC name
(4-nitrophenyl) acetate
State
State
At room temperature, p-Nitrophenyl acetate is typically found as a solid, taking the form of a crystalline powder. It is stable under normal conditions but may be sensitive to moisture.
Melting point (Celsius)
78.50
Melting point (Kelvin)
351.65
Boiling point (Celsius)
203.50
Boiling point (Kelvin)
476.65
General information
Molecular weight
181.14g/mol
Molar mass
181.1390g/mol
Density
1.2990g/cm3
Appearence
p-Nitrophenyl acetate is generally encountered as a pale yellow to amber-colored solid. It may appear as crystalline powder or flakes, consistent with its structure as an acetate ester. It is sensitive to moisture and light, leading to degradation upon prolonged exposure.
Comment on solubility

Solubility of (4-nitrophenyl) acetate

(4-nitrophenyl) acetate, with the chemical formula C8H8N2O4, is a compound that showcases interesting solubility properties. Understanding the solubility of this organic compound is essential in various applications, including pharmaceuticals and chemical synthesis.

Solubility Characteristics

The solubility of (4-nitrophenyl) acetate can be influenced by several factors:

  • Polarity: This compound exhibits both polar and non-polar characteristics due to its aromatic ring and acetyl group, which can impact its solubility in various solvents.
  • Solvent Interaction: It is known to be soluble in organic solvents such as ethanol, acetone, and dichloromethane, while it has limited solubility in water, reflecting the general principles of solubility where “like dissolves like.”
  • Temperature: As with many compounds, increasing the temperature can enhance the solubility of (4-nitrophenyl) acetate in certain solvents.

In summary, while (4-nitrophenyl) acetate may not be highly soluble in water, its solubility in organic solvents makes it a versatile compound for various chemical processes. Understanding these solubility properties aids in optimizing experimental conditions and potential applications.

Interesting facts

Interesting Facts about (4-nitrophenyl) Acetate

(4-nitrophenyl) acetate is an intriguing compound with a variety of applications in both organic synthesis and as a biochemical tool. It is a derivative of phenol and serves as an important building block in the production of pharmaceuticals and agrochemicals.

Key Characteristics

  • Role in Organic Chemistry: This compound is often used as an acylating agent, which means it is involved in introducing an acyl group into a molecule during chemical reactions. This is essential in forming esters and amides.
  • Biochemical Uses: (4-nitrophenyl) acetate is commonly employed in enzyme assays, notably as a substrate for lipases and esterases. Its hydrolysis can be monitored to measure enzyme activity, making it a valuable tool in enzymology.
  • Color Change Indicator: When hydrolyzed, (4-nitrophenyl) acetate generates 4-nitrophenol, which has a distinctive yellow color. This property is often used to facilitate visual demonstrations and quantitative analyses in laboratory settings.

Safety Considerations

While working with (4-nitrophenyl) acetate, it is essential to observe standard laboratory safety procedures. As it is a nitro compound, it can be hazardous:

  • Health Risks: Exposure may cause irritation to the skin, eyes, and respiratory systems.
  • Environmental Impact: Care should be taken to prevent contamination, as nitro compounds can be harmful to aquatic life.

In Summary

(4-nitrophenyl) acetate exemplifies the importance of small organic molecules in research and industry. With its diverse applications and distinctive properties, it remains a significant compound in both synthetic and applied chemistry. As scientists and students explore its potential, it continues to illustrate the fascinating world of chemical compounds.

Synonyms
4-Nitrophenyl acetate
830-03-5
p-Acetoxynitrobenzene
P-NITROPHENYL ACETATE
Acetic acid, 4-nitrophenyl ester
p-Nitrophenyl acetate (VAN)
NSC 2633
para-nitrophenyl acetate
EINECS 212-593-5
UNII-I902J0QH9S
BRN 0515874
I902J0QH9S
CHEBI:82635
PNP-ACETATE
AI3-00496
NSC-2633
4-O2NC6H4OAc
P-ACETOXY NITROBENZEN
P-NITROPHENYL ACETATES
DTXSID2061191
4-06-00-01298 (Beilstein Handbook Reference)
pAcetoxynitrobenzene
pNitrophenol acetate
pNitrophenyl acetate
Acetic acid pnitrophenyl ester
Acetic acid, pnitrophenyl ester
Acetic acid, 4nitrophenyl ester
DTXCID0048341
qauudnigjslpsx-uhfffaoysa-n
p-Nitrophenol acetate
(4-nitrophenyl) acetate
Acetic acid, p-nitrophenyl ester
Acetic acid p-nitrophenyl ester
Acetic acid 4-nitrophenyl ester
MFCD00007326
p-Nitrobenzene acetate
Phenol, p-nitro-, acetate
Acetic acid 4-nitro-phenyl ester
WLN: WNR DOV1
SCHEMBL74985
CHEMBL40988
BDBM11326
NSC2633
AKOS015833423
CS-W017169
FN00583
4-Nitrophenyl acetate, esterase substrate
AS-19298
SY010750
4-Nitrophenyl acetate, >=99.0% (GC)
DB-056674
A0040
NS00022825
F31024
Q27156150
K4V