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Sulfasalazine

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Identification
Molecular formula
C18H14N4O5S
CAS number
599-79-1
IUPAC name
4-oxo-4-[4-(thiazol-2-ylsulfamoyl)anilino]butanoic acid;hydrate
State
State

At room temperature, sulfasalazine typically exists as a solid.

Melting point (Celsius)
250.00
Melting point (Kelvin)
523.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
273.15
General information
Molecular weight
398.43g/mol
Molar mass
398.4270g/mol
Density
1.4760g/cm3
Appearence

Sulfasalazine is typically a yellow or yellow-brown crystalline powder.

Comment on solubility

Solubility of 4-oxo-4-[4-(thiazol-2-ylsulfamoyl)anilino]butanoic acid;hydrate

The solubility of 4-oxo-4-[4-(thiazol-2-ylsulfamoyl)anilino]butanoic acid;hydrate is a crucial property that influences its utility in various chemical applications. This compound, like many organic acids, exhibits specific behaviors in different solvents. Here are some key points to consider:

  • Polarity Matters: The presence of the polar thiazole and sulfonamide moieties suggests that the compound may have good solubility in polar solvents, particularly in water.
  • Hydration Effects: As this compound is a hydrate, the water molecules involved can enhance solubility through hydrogen bonding, potentially increasing its dissolution in aqueous environments.
  • pH Dependence: The solubility may vary with changes in pH, due to the acidic nature of the carboxylic acid group. Typically, higher solubility is observed in more basic conditions where deprotonation can occur.
  • Interactions with Solvents: The structure suggests potential interactions with solvents, which can impact solubility, influenced by factors such as temperature and ionic strength.
  • Experimental Validation: It is essential to conduct empirical studies to precisely define the solubility characteristics, as literature values can vary widely based on preparation methods and impurities.

In conclusion, while this compound is likely soluble in polar solvents, thorough experimental investigation is necessary to ascertain the exact solubility profile. Understanding these solubility properties is vital for practical applications in formulation chemistry and drug development.

Interesting facts

Interesting Facts about 4-oxo-4-[4-(thiazol-2-ylsulfamoyl)anilino]butanoic acid; hydrate

This compound, known as 4-oxo-4-[4-(thiazol-2-ylsulfamoyl)anilino]butanoic acid; hydrate, presents a fascinating intersection of chemistry, biology, and medicinal applications. Here are some noteworthy points about this compound:

  • Pharmaceutical Potential: This compound is part of a class of substances that may exhibit antibacterial and anti-inflammatory properties, making it a subject of interest in drug development.
  • Thiazole Ring: The thiazole moiety in its structure plays a significant role in its biological activity. Compounds containing thiazole rings are often linked to various therapeutic effects, including their role in combating infectious diseases.
  • Actions in Biology: Research suggests that compounds similar to this one can interact with biological targets, potentially leading to modifications in gene expression and enzyme activity.
  • Sulfamoyl Group: The presence of the sulfamoyl group enhances its chemical stability and can contribute to its efficacy as a drug. Sulfonamides have been heavily studied for their antibacterial properties.
  • Water Solubility: The hydrate form of this compound indicates that it can interact well with water, which is essential for its bioavailability when administered therapeutically.
  • Research Horizons: The compound's unique structure makes it an intriguing candidate for further studies, especially in exploring modifications that could enhance its potency or reduce potential side effects.

In summary, 4-oxo-4-[4-(thiazol-2-ylsulfamoyl)anilino]butanoic acid; hydrate is a prime example of how synthetic organic compounds can bridge the gap between chemistry and medicine. Its unique structural characteristics and potential biological implications invite further exploration and experimentation.

“The exploration of new compounds can lead to revolutionary advancements in medicine and the understanding of biological systems.”

Synonyms
Succinylsulfathiazole monohydrate
6101-17-3
N4-Succinylsulfathiazole monohydrate
UNII-HM7K18OJZ9
HM7K18OJZ9
4-oxo-4-[4-(1,3-thiazol-2-ylsulfamoyl)anilino]butanoic acid;hydrate
Sulfasuxidine (TN)
DTXSID10976489
Succinylsulfathiazole mono hydrate
AKOS024319090
SUCCINYLSULFATHIAZOLE MONOHYDRATE [MI]
D02447
Q27280005
4-oxo-4-{4-[(1,3-thiazol-2-ylamino)sulfonyl]anilino}butanoic acid hydrate
4-Oxo-4-{4-[(1,3-thiazol-2-yl)sulfamoyl]anilino}butanoic acid--water (1/1)
BUTANOIC ACID, 4-OXO-4-((4-((2-THIAZOLYLAMINO)SULFONYL)PHENYL)AMINO)-, MONOHYDRATE