Skip to main content

Torsemide

ADVERTISEMENT
Identification
Molecular formula
C16H20N4O3S
CAS number
56211-40-6
IUPAC name
4-oxo-N-(4-sulfamoylphenyl)chromene-2-carboxamide
State
State

At room temperature, Torsemide is in a solid state.

Melting point (Celsius)
163.50
Melting point (Kelvin)
436.65
Boiling point (Celsius)
268.50
Boiling point (Kelvin)
541.65
General information
Molecular weight
348.37g/mol
Molar mass
348.3720g/mol
Density
1.4860g/cm3
Appearence

Torsemide usually appears as a white to off-white crystalline powder. It is practically odorless.

Comment on solubility

Solubility of 4-oxo-N-(4-sulfamoylphenyl)chromene-2-carboxamide

The solubility of 4-oxo-N-(4-sulfamoylphenyl)chromene-2-carboxamide can be influenced by various factors. Understanding these can aid in both practical applications and further research. Here are some key points related to its solubility:

  • Polar Nature: Due to the presence of sulfonamide and carboxamide functional groups, this compound exhibits a degree of polarity, which typically enhances its solubility in polar solvents such as water.
  • Hydrogen Bonding: The ability to form hydrogen bonds with solvents further facilitates solubility. The carboxamide group is particularly effective in this regard.
  • Common Solvents: It is likely to be soluble in solvents like dimethyl sulfoxide (DMSO) and dimethylformamide (DMF) due to their polar characteristics.
  • pH Dependence: The solubility may also vary with pH; the ionization of the sulfonamide group can lead to increased solubility in basic conditions.

In summary, the solubility of 4-oxo-N-(4-sulfamoylphenyl)chromene-2-carboxamide is a multifaceted property influenced by its chemical structure and the solvent characteristics. The incorporation of polar and ionizable functional groups typically suggests a favorable solubility profile in appropriate solvents.

Interesting facts

Interesting Facts about 4-oxo-N-(4-sulfamoylphenyl)chromene-2-carboxamide

4-oxo-N-(4-sulfamoylphenyl)chromene-2-carboxamide is a fascinating compound that merges the realms of bioactivity and chemical structure. Its design allows it to showcase properties that are pivotal in medicinal chemistry. Here are some notable aspects:

  • Structural Significance: The compound features a chromene backbone, which is integral to many natural products and can also act as a pharmacophore in drug design. Its unique structural characteristics contribute to its biological functions.
  • Potential Therapeutic Applications: This compound is a derivative of sulfanilamide and is being studied for its potential as an antibacterial agent, showcasing how chemical modifications can lead to compounds with significant therapeutic value.
  • Mechanism of Action: The sulfamoyl group present in the structure lends itself to interactions that can inhibit bacterial growth through the competitive inhibition of folate synthesis, a vital pathway in microorganisms.
  • Research Interest: Scientists are keen on exploring the versatility of this compound by conducting studies geared towards its efficacy and safety, leading researchers to investigate modifications that could enhance its performance.

As a part of ongoing research into the pharmacological properties of synthetic compounds, 4-oxo-N-(4-sulfamoylphenyl)chromene-2-carboxamide serves as a compelling example of how complex chemical structures can be utilized in the fight against bacterial infections. The interplay between its structure and activity makes it a valuable focal point for future studies.

Synonyms
3845-20-3
BRN 1266387
4H-1-BENZOPYRAN-2-CARBOXANILIDE, 4-OXO-4'-SULFAMOYL-
4-Oxo-4'-sulfamoyl-4H-1-benzopyran-2-carboxanilide
DTXSID40191769
DTXCID30114260
4-Oxo-N-(4-sulfamoylphenyl)-4H-1-benzopyran-2-carboxamide
4-oxo-N-(4-sulfamoylphenyl)-4H-chromene-2-carboxamide
Oprea1_305059
MLS001176798
CHEMBL1389064
HMS2891K14
STK864893
AKOS001281482
CCG-146175
NCGC00246015-01
SMR000591982
Z27682901