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Lobeline

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Identification
Molecular formula
C22H27NO2
CAS number
90-69-7
IUPAC name
[4-phenyl-1-(2-phenylethyl)azepan-4-yl] propanoate
State
State

At room temperature, lobeline is in a solid state. It can take the form of crystalline powders and is relatively stable at standard conditions. As with most organic solids, it should be stored in a cool, dry place to ensure stability and minimize any reaction with environmental factors such as moisture.

Melting point (Celsius)
132.00
Melting point (Kelvin)
405.15
Boiling point (Celsius)
430.00
Boiling point (Kelvin)
703.15
General information
Molecular weight
305.43g/mol
Molar mass
305.4260g/mol
Density
1.0800g/cm3
Appearence

Lobeline typically appears as a crystalline solid. The crystals can vary in color from white to off-white and are usually clear. As a solid, it may also be available in powder form for various applications. It is important to handle lobeline with care, as with many chemical compounds, to maintain its integrity and prevent degradation.

Comment on solubility

Solubility Characteristics of [4-phenyl-1-(2-phenylethyl)azepan-4-yl] propanoate

The solubility of [4-phenyl-1-(2-phenylethyl)azepan-4-yl] propanoate in various solvents can be quite intricate due to its organic structure. Here are some key points to consider:

  • Polarity: As an aromatic compound, the presence of phenyl groups typically suggests that it may have limited solubility in polar solvents such as water. Instead, it is likely to be more soluble in non-polar solvents.
  • Hydrophobic Interactions: The hydrophobic nature of the phenyl rings contributes to its solubility in organic solvents like ethanol, methanol, and chloroform.
  • Solvent Interactions: The specific solubility also depends on the interaction of the compound with solvent molecules, where factors such as temperature, pH, and solvent quality play pivotal roles.
  • Concentration Effects: At higher concentrations, the solubility may shift due to aggregation or other solute-solvent interactions.

In conclusion, while [4-phenyl-1-(2-phenylethyl)azepan-4-yl] propanoate exhibits complex solubility behaviors, it is essential to conduct empirical studies to determine its solubility profile accurately. Understanding its solubility is crucial for practical applications, especially in pharmaceutical formulations where bioavailability can greatly influence efficacy.

Interesting facts

Interesting Facts about [4-phenyl-1-(2-phenylethyl)azepan-4-yl] propanoate

[4-phenyl-1-(2-phenylethyl)azepan-4-yl] propanoate is a fascinating compound that has garnered attention in the fields of organic chemistry and pharmacology. Here are some intriguing aspects of this compound:

  • Complex Structure: The compound features a unique azepane ring, which is a seven-membered cyclic amine. This structural motif enhances the molecule's ability to interact with biological systems effectively.
  • Potential Pharmacological Activities: Azepane derivatives are studied for their potential in various therapeutic areas, including their roles as anxiolytics, antidepressants, and neuroprotective agents. This particular compound's structure suggests that it might possess similar bioactive properties.
  • Stimulating Interest in Medicinal Chemistry: Researchers are eager to explore how modifications to the azepane ring or the phenyl groups influence the compound's biological activity, leading to the development of novel medications.
  • Applications in Drug Design: The presence of both a phenyl group and an ethyl group offers opportunities for optimization in drug development, particularly in increasing lipophilicity and enhancing receptor binding affinity.
  • Historical Context: Compounds containing azepane structures have been utilized in many synthetic processes since their introduction in the 19th century, showcasing the long-standing significance of these compounds in chemistry.

This compound exemplifies the intricate balance between structural complexity and potential applications in medicinal science. As scientists continue to dissect its properties, [4-phenyl-1-(2-phenylethyl)azepan-4-yl] propanoate remains a promising candidate worthy of further investigation in the quest for new therapeutic agents.

Synonyms
1-Phenethyl-4-phenyl-4-propionyloxyazacycloheptane
3397-67-9
BRN 1398658
1-Phenethyl-4-phenylhexahydro-1H-azepin-4-ol propionate (ester)
1H-AZEPIN-4-OL, HEXAHYDRO-1-PHENETHYL-4-PHENYL-, PROPIONATE (ester)
5-21-02-00398 (Beilstein Handbook Reference)
DTXSID90955550
4-Phenyl-1-(2-phenylethyl)azepan-4-yl propanoate